METTL9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	26% ± 9%	Explore
endothelial cell	28 studies	29% ± 12%	Explore
classical monocyte	26 studies	45% ± 16%	Explore
CD4-positive, alpha-beta T cell	26 studies	25% ± 8%	Explore
fibroblast	25 studies	26% ± 12%	Explore
CD8-positive, alpha-beta T cell	23 studies	25% ± 9%	Explore
T cell	21 studies	27% ± 10%	Explore
macrophage	20 studies	21% ± 7%	Explore
B cell	17 studies	23% ± 7%	Explore
monocyte	17 studies	35% ± 15%	Explore
regulatory T cell	17 studies	24% ± 5%	Explore
conventional dendritic cell	13 studies	29% ± 17%	Explore
smooth muscle cell	13 studies	26% ± 9%	Explore
gamma-delta T cell	13 studies	32% ± 14%	Explore
endothelial cell of lymphatic vessel	12 studies	27% ± 8%	Explore
epithelial cell	12 studies	40% ± 21%	Explore
pericyte	12 studies	29% ± 10%	Explore
naive B cell	11 studies	19% ± 4%	Explore
mature NK T cell	11 studies	26% ± 5%	Explore
connective tissue cell	11 studies	33% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	27% ± 7%	Explore
basal cell	10 studies	31% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
endothelial cell of vascular tree	10 studies	22% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	23% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	26% ± 8%	Explore
memory B cell	9 studies	19% ± 3%	Explore
dendritic cell	9 studies	29% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	28% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	27% ± 5%	Explore
abnormal cell	8 studies	27% ± 8%	Explore
endothelial cell of artery	8 studies	26% ± 10%	Explore
vein endothelial cell	8 studies	26% ± 10%	Explore
T follicular helper cell	8 studies	27% ± 7%	Explore
ciliated cell	8 studies	29% ± 12%	Explore
secretory cell	7 studies	24% ± 10%	Explore
non-classical monocyte	7 studies	29% ± 13%	Explore
capillary endothelial cell	7 studies	24% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	41% ± 16%	Explore
myofibroblast cell	7 studies	34% ± 5%	Explore
neuron	7 studies	44% ± 21%	Explore
microglial cell	7 studies	28% ± 7%	Explore
mucosal invariant T cell	7 studies	26% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
leukocyte	6 studies	25% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	28% ± 7%	Explore
innate lymphoid cell	6 studies	25% ± 6%	Explore
myeloid cell	6 studies	42% ± 15%	Explore
hematopoietic precursor cell	5 studies	40% ± 17%	Explore
neutrophil	5 studies	30% ± 14%	Explore
kidney loop of Henle epithelial cell	5 studies	27% ± 2%	Explore
progenitor cell	5 studies	29% ± 7%	Explore
enteroendocrine cell	5 studies	30% ± 13%	Explore
mesothelial cell	5 studies	39% ± 17%	Explore
astrocyte	5 studies	28% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 12%	Explore
erythrocyte	5 studies	26% ± 13%	Explore
plasmacytoid dendritic cell	5 studies	28% ± 9%	Explore
pancreatic A cell	4 studies	30% ± 8%	Explore
exhausted T cell	4 studies	24% ± 8%	Explore
glutamatergic neuron	4 studies	36% ± 14%	Explore
hematopoietic stem cell	4 studies	25% ± 4%	Explore
lymphocyte	4 studies	30% ± 5%	Explore
pro-B cell	4 studies	22% ± 1%	Explore
plasma cell	4 studies	34% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	18% ± 2%	Explore
goblet cell	4 studies	25% ± 12%	Explore
T-helper 17 cell	4 studies	30% ± 10%	Explore
squamous epithelial cell	3 studies	35% ± 27%	Explore
plasmablast	3 studies	41% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	49% ± 20%	Explore
neural crest cell	3 studies	54% ± 26%	Explore
immature B cell	3 studies	19% ± 3%	Explore
precursor B cell	3 studies	25% ± 9%	Explore
retina horizontal cell	3 studies	28% ± 16%	Explore
retinal cone cell	3 studies	66% ± 18%	Explore
retinal pigment epithelial cell	3 studies	42% ± 22%	Explore
intraepithelial lymphocyte	3 studies	31% ± 15%	Explore
CD4-positive helper T cell	3 studies	27% ± 7%	Explore
intermediate monocyte	3 studies	50% ± 23%	Explore
luminal cell of prostate epithelium	3 studies	26% ± 6%	Explore
pancreatic ductal cell	3 studies	35% ± 8%	Explore
intestinal crypt stem cell	3 studies	23% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 12%	Explore
GABAergic neuron	3 studies	35% ± 9%	Explore
interneuron	3 studies	33% ± 15%	Explore
mononuclear phagocyte	3 studies	31% ± 13%	Explore
mast cell	3 studies	18% ± 1%	Explore
oligodendrocyte precursor cell	3 studies	37% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	32% ± 10%	Explore
lung	11 studies	30% ± 11%	Explore
kidney	8 studies	28% ± 6%	Explore
intestine	8 studies	28% ± 14%	Explore
brain	7 studies	25% ± 8%	Explore
bone marrow	4 studies	24% ± 5%	Explore
eye	4 studies	31% ± 10%	Explore
uterus	4 studies	27% ± 15%	Explore
lymph node	4 studies	27% ± 6%	Explore
breast	4 studies	18% ± 2%	Explore
liver	4 studies	34% ± 17%	Explore
pancreas	3 studies	39% ± 6%	Explore
adrenal gland	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	3712.61	180 / 180	100%	47.72	430 / 430
stomach	100%	2959.14	359 / 359	100%	40.66	286 / 286
esophagus	100%	3728.52	1444 / 1445	100%	40.04	183 / 183
brain	100%	4804.00	2640 / 2642	100%	65.38	705 / 705
breast	100%	4503.53	459 / 459	100%	54.76	1117 / 1118
skin	100%	6044.35	1807 / 1809	100%	103.13	472 / 472
prostate	100%	4096.15	245 / 245	100%	59.74	501 / 502
uterus	100%	3903.83	170 / 170	100%	48.96	458 / 459
kidney	100%	7802.94	89 / 89	100%	91.41	898 / 901
thymus	100%	4496.05	653 / 653	100%	69.29	602 / 605
lung	100%	4098.24	576 / 578	100%	47.63	1153 / 1155
bladder	100%	4047.81	21 / 21	99%	44.41	501 / 504
intestine	100%	3548.35	966 / 966	99%	42.22	523 / 527
pancreas	100%	1984.65	327 / 328	99%	38.63	176 / 178
adrenal gland	100%	8039.15	258 / 258	97%	45.94	223 / 230
adipose	100%	4750.83	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	226.43	80 / 80
lymph node	0%	0	0 / 0	100%	35.54	29 / 29
muscle	100%	3784.98	803 / 803	0%	0	0 / 0
spleen	100%	4438.00	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	39.15	45 / 45
ureter	0%	0	0 / 0	100%	36.23	1 / 1
peripheral blood	100%	11783.47	928 / 929	0%	0	0 / 0
blood vessel	100%	3051.66	1332 / 1335	0%	0	0 / 0
heart	96%	2326.90	828 / 861	0%	0	0 / 0
liver	38%	406.12	87 / 226	39%	9.05	160 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	METTL9
Protein name	Protein-L-histidine N-pros-methyltransferase (EC 2.1.1.-) (DORA reverse strand protein) (DREV) (DREV1) (Methyltransferase-like protein 9) (hMETTL9) Methyltransferase like 9
Synonyms	CGI-81 DREV
Description	FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins . Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) . Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins . Constitutes the main methyltransferase for the 1-methylhistidine modification in cell . .
Accessions	H3BQD2 H3BTS9 ENST00000562379.1 ENST00000358154.8 [Q9H1A3-1] H3BRP5 Q9H1A3 ENST00000567404.5 ENST00000569290.1 H3BPE9 ENST00000570074.1 ENST00000562961.1 ENST00000568826.1 H3BM54 H3BN86 ENST00000396014.8 [Q9H1A3-2]

GO_0032259	Biological process	methylation
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005739	Cellular component	mitochondrion
GO_0106370	Molecular function	protein-L-histidine N-pros-methyltransferase activity
GO_0005515	Molecular function	protein binding

METTL9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review