MED10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	31 studies	29% ± 10%	Explore
B cell	27 studies	27% ± 12%	Explore
CD4-positive, alpha-beta T cell	26 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	26 studies	28% ± 11%	Explore
T cell	21 studies	23% ± 5%	Explore
endothelial cell	20 studies	25% ± 10%	Explore
regulatory T cell	20 studies	27% ± 7%	Explore
memory B cell	18 studies	27% ± 9%	Explore
pericyte	17 studies	18% ± 3%	Explore
naive B cell	16 studies	27% ± 7%	Explore
fibroblast	16 studies	23% ± 8%	Explore
endothelial cell of lymphatic vessel	15 studies	28% ± 9%	Explore
gamma-delta T cell	14 studies	32% ± 11%	Explore
mature NK T cell	13 studies	30% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	30% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	36% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	32% ± 8%	Explore
plasmacytoid dendritic cell	12 studies	29% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	34% ± 8%	Explore
mucosal invariant T cell	10 studies	32% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	28% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	34% ± 17%	Explore
smooth muscle cell	9 studies	18% ± 3%	Explore
non-classical monocyte	8 studies	33% ± 17%	Explore
basal cell	8 studies	29% ± 13%	Explore
classical monocyte	7 studies	25% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	28% ± 5%	Explore
epithelial cell	7 studies	36% ± 19%	Explore
ciliated cell	7 studies	31% ± 11%	Explore
plasma cell	6 studies	30% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	27% ± 6%	Explore
abnormal cell	6 studies	28% ± 8%	Explore
endothelial cell of vascular tree	6 studies	19% ± 2%	Explore
capillary endothelial cell	6 studies	19% ± 2%	Explore
T follicular helper cell	6 studies	26% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	33% ± 18%	Explore
vein endothelial cell	5 studies	17% ± 2%	Explore
precursor B cell	5 studies	28% ± 6%	Explore
innate lymphoid cell	5 studies	27% ± 6%	Explore
plasmablast	4 studies	50% ± 15%	Explore
leukocyte	4 studies	25% ± 7%	Explore
exhausted T cell	4 studies	31% ± 10%	Explore
endothelial cell of artery	4 studies	19% ± 1%	Explore
pro-B cell	4 studies	25% ± 4%	Explore
connective tissue cell	4 studies	23% ± 5%	Explore
immature B cell	4 studies	25% ± 6%	Explore
mast cell	4 studies	18% ± 1%	Explore
T-helper 17 cell	4 studies	23% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 9%	Explore
pancreatic A cell	3 studies	34% ± 10%	Explore
conventional dendritic cell	3 studies	41% ± 15%	Explore
neuron	3 studies	28% ± 10%	Explore
retinal bipolar neuron	3 studies	24% ± 5%	Explore
lymphocyte	3 studies	32% ± 9%	Explore
myofibroblast cell	3 studies	23% ± 3%	Explore
amacrine cell	3 studies	35% ± 10%	Explore
retina horizontal cell	3 studies	29% ± 11%	Explore
type I pneumocyte	3 studies	27% ± 3%	Explore
enteroendocrine cell	3 studies	23% ± 11%	Explore
goblet cell	3 studies	22% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 9%	Explore
secretory cell	3 studies	29% ± 14%	Explore
glutamatergic neuron	3 studies	28% ± 9%	Explore
T-helper 1 cell	3 studies	30% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	30% ± 11%	Explore
double negative thymocyte	3 studies	43% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	31% ± 11%	Explore
lung	8 studies	26% ± 10%	Explore
brain	5 studies	20% ± 3%	Explore
intestine	4 studies	23% ± 10%	Explore
lymph node	4 studies	26% ± 3%	Explore
kidney	3 studies	18% ± 2%	Explore
eye	3 studies	20% ± 5%	Explore
liver	3 studies	25% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1364.39	1445 / 1445	100%	41.46	183 / 183
ovary	100%	1061.97	180 / 180	100%	47.58	430 / 430
stomach	100%	1038.82	359 / 359	100%	42.79	286 / 286
brain	100%	1359.88	2639 / 2642	100%	49.76	705 / 705
thymus	100%	1030.02	653 / 653	100%	41.68	604 / 605
intestine	100%	1517.07	966 / 966	100%	47.38	526 / 527
skin	100%	1425.07	1809 / 1809	100%	45.87	471 / 472
uterus	100%	1223.99	170 / 170	100%	69.74	458 / 459
lung	100%	1107.18	577 / 578	100%	66.77	1154 / 1155
pancreas	100%	623.02	327 / 328	100%	47.84	178 / 178
bladder	100%	1435.76	21 / 21	100%	56.76	502 / 504
adrenal gland	100%	1025.85	258 / 258	100%	55.69	229 / 230
prostate	100%	1217.36	245 / 245	99%	39.95	499 / 502
breast	100%	1347.07	459 / 459	99%	43.38	1109 / 1118
kidney	100%	1003.00	89 / 89	99%	39.10	893 / 901
liver	100%	644.74	226 / 226	99%	31.07	402 / 406
adipose	100%	1406.90	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1488.86	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	62.91	29 / 29
spleen	100%	1311.51	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.40	45 / 45
ureter	0%	0	0 / 0	100%	36.35	1 / 1
muscle	100%	981.93	800 / 803	0%	0	0 / 0
heart	99%	814.97	855 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	24.93	79 / 80
peripheral blood	86%	745.51	800 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051123	Biological process	RNA polymerase II preinitiation complex assembly
GO_0016567	Biological process	protein ubiquitination
GO_0060261	Biological process	positive regulation of transcription initiation by RNA polymerase II
GO_0032968	Biological process	positive regulation of transcription elongation by RNA polymerase II
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0016592	Cellular component	mediator complex
GO_0005654	Cellular component	nucleoplasm
GO_0070847	Cellular component	core mediator complex
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding
GO_0003712	Molecular function	transcription coregulator activity

IV. Literature review

[source]

Gene name	MED10
Protein name	Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20)
Synonyms	TRG20 TRG17 L6
Description	FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Accessions	Q9BTT4 ENST00000255764.4 ENST00000708561.1

MED10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review