LIMD2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	43 studies	56% ± 20%	Explore
B cell	42 studies	64% ± 22%	Explore
CD8-positive, alpha-beta T cell	37 studies	56% ± 23%	Explore
T cell	32 studies	51% ± 22%	Explore
CD4-positive, alpha-beta T cell	32 studies	59% ± 23%	Explore
conventional dendritic cell	27 studies	57% ± 22%	Explore
regulatory T cell	27 studies	63% ± 21%	Explore
classical monocyte	24 studies	53% ± 18%	Explore
non-classical monocyte	23 studies	69% ± 20%	Explore
memory B cell	20 studies	74% ± 13%	Explore
naive B cell	20 studies	74% ± 10%	Explore
mature NK T cell	19 studies	57% ± 18%	Explore
plasmacytoid dendritic cell	19 studies	39% ± 13%	Explore
monocyte	18 studies	45% ± 15%	Explore
gamma-delta T cell	18 studies	55% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	62% ± 20%	Explore
mucosal invariant T cell	16 studies	52% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	63% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	70% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	75% ± 12%	Explore
macrophage	14 studies	30% ± 13%	Explore
dendritic cell	12 studies	66% ± 25%	Explore
plasma cell	12 studies	40% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	62% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	56% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	65% ± 24%	Explore
plasmablast	10 studies	58% ± 21%	Explore
T follicular helper cell	10 studies	63% ± 20%	Explore
myeloid cell	10 studies	37% ± 20%	Explore
innate lymphoid cell	9 studies	41% ± 19%	Explore
neutrophil	8 studies	39% ± 19%	Explore
immature B cell	7 studies	85% ± 14%	Explore
CD4-positive helper T cell	6 studies	34% ± 16%	Explore
platelet	6 studies	29% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	77% ± 14%	Explore
leukocyte	6 studies	42% ± 16%	Explore
hematopoietic stem cell	6 studies	49% ± 16%	Explore
precursor B cell	6 studies	74% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	68% ± 23%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	61% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	53% ± 8%	Explore
hematopoietic precursor cell	5 studies	54% ± 25%	Explore
exhausted T cell	5 studies	86% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	79% ± 20%	Explore
pro-B cell	5 studies	49% ± 14%	Explore
T-helper 17 cell	5 studies	58% ± 25%	Explore
double negative thymocyte	5 studies	69% ± 17%	Explore
intermediate monocyte	5 studies	58% ± 26%	Explore
mast cell	5 studies	44% ± 20%	Explore
group 3 innate lymphoid cell	4 studies	65% ± 13%	Explore
microglial cell	4 studies	23% ± 6%	Explore
germinal center B cell	4 studies	79% ± 15%	Explore
T-helper 1 cell	4 studies	65% ± 23%	Explore
erythrocyte	4 studies	47% ± 13%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	71% ± 23%	Explore
mononuclear phagocyte	3 studies	48% ± 17%	Explore
endothelial cell of lymphatic vessel	3 studies	35% ± 10%	Explore
pericyte	3 studies	20% ± 2%	Explore
lymphocyte	3 studies	39% ± 16%	Explore
intraepithelial lymphocyte	3 studies	59% ± 24%	Explore
granulocyte	3 studies	50% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	71% ± 10%	Explore
double-positive, alpha-beta thymocyte	3 studies	70% ± 7%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	62% ± 15%	Explore
lung	8 studies	24% ± 5%	Explore
bone marrow	5 studies	38% ± 21%	Explore
lymph node	5 studies	50% ± 22%	Explore
kidney	3 studies	41% ± 15%	Explore
intestine	3 studies	23% ± 4%	Explore
brain	3 studies	25% ± 6%	Explore
liver	3 studies	35% ± 6%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1964.34	578 / 578	95%	21.25	1092 / 1155
uterus	95%	610.48	162 / 170	98%	28.26	450 / 459
ovary	96%	581.89	173 / 180	95%	20.07	410 / 430
prostate	99%	1379.03	243 / 245	91%	11.73	456 / 502
brain	87%	1176.46	2290 / 2642	96%	15.85	678 / 705
breast	97%	633.82	446 / 459	82%	15.25	917 / 1118
kidney	97%	957.54	86 / 89	77%	12.31	695 / 901
intestine	94%	1625.42	910 / 966	71%	11.65	375 / 527
skin	68%	334.43	1236 / 1809	97%	52.08	457 / 472
stomach	88%	495.37	315 / 359	76%	12.80	218 / 286
bladder	71%	653.76	15 / 21	90%	23.62	455 / 504
thymus	92%	793.15	599 / 653	67%	30.33	404 / 605
adrenal gland	93%	526.08	239 / 258	57%	6.21	130 / 230
esophagus	66%	331.81	959 / 1445	79%	10.84	145 / 183
pancreas	44%	204.46	144 / 328	89%	21.40	159 / 178
liver	69%	353.53	155 / 226	55%	9.83	224 / 406
lymph node	0%	0	0 / 0	100%	371.05	29 / 29
peripheral blood	100%	18116.28	929 / 929	0%	0	0 / 0
spleen	100%	12759.97	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	18.29	1 / 1
adipose	98%	836.21	1179 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	98%	32.24	78 / 80
tonsil	0%	0	0 / 0	96%	31.96	43 / 45
blood vessel	70%	502.90	933 / 1335	0%	0	0 / 0
heart	66%	346.95	568 / 861	0%	0	0 / 0
muscle	2%	9.47	20 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0