KDELR2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	33 studies	46% ± 18%	Explore
natural killer cell	28 studies	26% ± 6%	Explore
macrophage	26 studies	29% ± 10%	Explore
endothelial cell	26 studies	36% ± 15%	Explore
plasma cell	23 studies	52% ± 23%	Explore
conventional dendritic cell	20 studies	28% ± 13%	Explore
pericyte	20 studies	35% ± 15%	Explore
epithelial cell	19 studies	45% ± 23%	Explore
smooth muscle cell	19 studies	30% ± 9%	Explore
classical monocyte	18 studies	26% ± 11%	Explore
plasmacytoid dendritic cell	17 studies	35% ± 10%	Explore
connective tissue cell	17 studies	50% ± 19%	Explore
endothelial cell of lymphatic vessel	16 studies	32% ± 12%	Explore
regulatory T cell	16 studies	22% ± 7%	Explore
CD8-positive, alpha-beta T cell	15 studies	27% ± 10%	Explore
T cell	14 studies	21% ± 4%	Explore
basal cell	14 studies	38% ± 16%	Explore
non-classical monocyte	14 studies	26% ± 11%	Explore
monocyte	13 studies	25% ± 8%	Explore
plasmablast	12 studies	61% ± 23%	Explore
CD4-positive, alpha-beta T cell	12 studies	26% ± 10%	Explore
capillary endothelial cell	12 studies	25% ± 8%	Explore
myofibroblast cell	12 studies	41% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	27% ± 6%	Explore
B cell	11 studies	21% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	25% ± 8%	Explore
goblet cell	11 studies	50% ± 22%	Explore
vein endothelial cell	11 studies	29% ± 11%	Explore
gamma-delta T cell	11 studies	23% ± 8%	Explore
mature NK T cell	10 studies	21% ± 4%	Explore
endothelial cell of artery	10 studies	28% ± 8%	Explore
endothelial cell of vascular tree	10 studies	32% ± 9%	Explore
secretory cell	9 studies	41% ± 13%	Explore
abnormal cell	9 studies	39% ± 13%	Explore
mucosal invariant T cell	9 studies	20% ± 3%	Explore
myeloid cell	9 studies	34% ± 13%	Explore
ciliated cell	9 studies	37% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	22% ± 6%	Explore
IgG plasma cell	8 studies	40% ± 14%	Explore
dendritic cell	8 studies	32% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	25% ± 10%	Explore
club cell	7 studies	31% ± 13%	Explore
progenitor cell	7 studies	48% ± 18%	Explore
mesothelial cell	7 studies	43% ± 20%	Explore
IgA plasma cell	7 studies	41% ± 16%	Explore
respiratory goblet cell	6 studies	35% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	28% ± 12%	Explore
leukocyte	6 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	22% ± 3%	Explore
enterocyte	6 studies	42% ± 17%	Explore
innate lymphoid cell	6 studies	22% ± 3%	Explore
T follicular helper cell	6 studies	17% ± 1%	Explore
memory B cell	6 studies	17% ± 2%	Explore
type I pneumocyte	5 studies	31% ± 12%	Explore
hematopoietic precursor cell	5 studies	26% ± 9%	Explore
mononuclear phagocyte	5 studies	32% ± 14%	Explore
epithelial cell of proximal tubule	5 studies	24% ± 8%	Explore
transit amplifying cell	5 studies	35% ± 17%	Explore
type II pneumocyte	5 studies	38% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 10%	Explore
mast cell	5 studies	19% ± 1%	Explore
alveolar macrophage	4 studies	20% ± 3%	Explore
pancreatic A cell	4 studies	61% ± 12%	Explore
type B pancreatic cell	4 studies	50% ± 18%	Explore
exhausted T cell	4 studies	37% ± 5%	Explore
enteroendocrine cell	4 studies	49% ± 11%	Explore
intestinal crypt stem cell	4 studies	36% ± 13%	Explore
adventitial cell	4 studies	50% ± 10%	Explore
mucus secreting cell	4 studies	43% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	32% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	40% ± 5%	Explore
oligodendrocyte precursor cell	4 studies	24% ± 6%	Explore
duct epithelial cell	3 studies	28% ± 5%	Explore
ionocyte	3 studies	22% ± 3%	Explore
pancreatic D cell	3 studies	51% ± 15%	Explore
glomerular endothelial cell	3 studies	24% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	28% ± 7%	Explore
neural crest cell	3 studies	31% ± 2%	Explore
lymphocyte	3 studies	32% ± 11%	Explore
neuroendocrine cell	3 studies	28% ± 8%	Explore
astrocyte	3 studies	20% ± 6%	Explore
microglial cell	3 studies	30% ± 11%	Explore
serous secreting cell	3 studies	34% ± 12%	Explore
intermediate monocyte	3 studies	35% ± 13%	Explore
myoepithelial cell	3 studies	36% ± 13%	Explore
neuron	3 studies	35% ± 18%	Explore
luminal cell of prostate epithelium	3 studies	42% ± 6%	Explore
IgM plasma cell	3 studies	47% ± 8%	Explore
GABAergic neuron	3 studies	28% ± 13%	Explore
glutamatergic neuron	3 studies	31% ± 15%	Explore
acinar cell	3 studies	48% ± 20%	Explore
pancreatic ductal cell	3 studies	49% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	33% ± 13%	Explore
glial cell	3 studies	34% ± 21%	Explore
hepatocyte	3 studies	53% ± 31%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 8%	Explore
T-helper 17 cell	3 studies	33% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 2%	Explore
double negative thymocyte	3 studies	26% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	25% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	33% ± 15%	Explore
peripheral blood	13 studies	24% ± 5%	Explore
intestine	12 studies	33% ± 17%	Explore
kidney	7 studies	28% ± 8%	Explore
brain	5 studies	31% ± 11%	Explore
pancreas	4 studies	55% ± 15%	Explore
placenta	4 studies	49% ± 32%	Explore
bone marrow	4 studies	21% ± 6%	Explore
uterus	4 studies	40% ± 18%	Explore
lymph node	4 studies	26% ± 18%	Explore
breast	4 studies	31% ± 5%	Explore
liver	4 studies	34% ± 22%	Explore
eye	3 studies	23% ± 5%	Explore
skin	3 studies	26% ± 7%	Explore
prostate	3 studies	33% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	9278.85	459 / 459	100%	299.88	1118 / 1118
esophagus	100%	6946.83	1445 / 1445	100%	268.63	183 / 183
intestine	100%	9194.43	966 / 966	100%	293.23	527 / 527
liver	100%	14429.77	226 / 226	100%	237.29	406 / 406
lung	100%	10512.76	578 / 578	100%	284.15	1155 / 1155
ovary	100%	7915.27	180 / 180	100%	190.85	430 / 430
pancreas	100%	7537.06	328 / 328	100%	271.64	178 / 178
prostate	100%	9478.27	245 / 245	100%	382.95	502 / 502
stomach	100%	8984.26	359 / 359	100%	290.45	286 / 286
uterus	100%	9555.19	170 / 170	100%	237.47	459 / 459
bladder	100%	8883.90	21 / 21	100%	254.90	503 / 504
skin	100%	12817.68	1808 / 1809	100%	247.94	471 / 472
kidney	100%	7378.96	89 / 89	100%	179.42	897 / 901
thymus	100%	10366.22	653 / 653	99%	181.21	601 / 605
adrenal gland	100%	8806.16	258 / 258	99%	152.77	227 / 230
brain	95%	2820.25	2512 / 2642	99%	134.77	701 / 705
adipose	100%	10264.07	1204 / 1204	0%	0	0 / 0
blood vessel	100%	11221.39	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	88.72	29 / 29
spleen	100%	5938.50	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	162.62	45 / 45
ureter	0%	0	0 / 0	100%	214.21	1 / 1
heart	99%	5796.61	851 / 861	0%	0	0 / 0
muscle	97%	3037.51	779 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	94%	98.10	75 / 80
peripheral blood	69%	2423.64	645 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0015031	Biological process	protein transport
GO_0035437	Biological process	maintenance of protein localization in endoplasmic reticulum
GO_0006888	Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport
GO_0006890	Biological process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0006621	Biological process	protein retention in ER lumen
GO_0030663	Cellular component	COPI-coated vesicle membrane
GO_0000139	Cellular component	Golgi membrane
GO_0005801	Cellular component	cis-Golgi network
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0030133	Cellular component	transport vesicle
GO_0005046	Molecular function	KDEL sequence binding
GO_0046923	Molecular function	ER retention sequence binding

IV. Literature review

[source]

Gene name	KDELR2
Protein name	KDEL endoplasmic reticulum protein retention receptor 2 ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2)
Synonyms	ERD2.2
Description	FUNCTION: Membrane receptor that binds the K-D-E-L sequence motif in the C-terminal part of endoplasmic reticulum resident proteins and maintains their localization in that compartment by participating to their vesicle-mediated recycling back from the Golgi . Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity). .
Accessions	ENST00000382267.3 P33947 ENST00000258739.9 [P33947-1] H7BYF7 ENST00000490996.1 [P33947-2]

KDELR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review