IMPDH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097294Biological process'de novo' XMP biosynthetic process
GO_0071353Biological processcellular response to interleukin-4
GO_0046651Biological processlymphocyte proliferation
GO_0007623Biological processcircadian rhythm
GO_0006177Biological processGMP biosynthetic process
GO_0006183Biological processGTP biosynthetic process
GO_0005778Cellular componentperoxisomal membrane
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003938Molecular functionIMP dehydrogenase activity
GO_0000166Molecular functionnucleotide binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIMPDH2
Protein nameIMP dehydrogenase (EC 1.1.1.205)
Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205)
Inosine monophosphate dehydrogenase 2
Inosine-5'-monophosphate dehydrogenase 2 (IMP dehydrogenase 2) (IMPD 2) (IMPDH 2) (EC 1.1.1.205) (Inosine-5'-monophosphate dehydrogenase type II) (IMP dehydrogenase II) (IMPDH-II)
Inosine monophosphate dehydrogenase type II
SynonymsIMPDH
IMPD2
DescriptionFUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth . Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism . It may also have a role in the development of malignancy and the growth progression of some tumors. .

FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. .

FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. .

FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. .

FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. .

AccessionsENST00000678724.1
P12268
ENST00000326739.9
A0A7I2V2T3
A0A7I2V337
ENST00000429182.6
Q6RUP8
A0A7I2YQK5
Q6QE17
A0A7I2V5N6
ENST00000677010.1
ENST00000679117.1
ENST00000442157.2
Q6RUP9
E7ETK5
ENST00000677480.1
H0Y4R1