IFT25 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	25% ± 10%	Explore
ciliated cell	17 studies	61% ± 16%	Explore
CD8-positive, alpha-beta T cell	16 studies	27% ± 10%	Explore
T cell	11 studies	27% ± 8%	Explore
fibroblast	11 studies	25% ± 11%	Explore
regulatory T cell	11 studies	22% ± 7%	Explore
mature NK T cell	10 studies	18% ± 2%	Explore
CD4-positive, alpha-beta T cell	9 studies	27% ± 9%	Explore
endothelial cell	9 studies	23% ± 6%	Explore
B cell	8 studies	22% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	22% ± 5%	Explore
conventional dendritic cell	8 studies	26% ± 11%	Explore
gamma-delta T cell	8 studies	22% ± 12%	Explore
plasma cell	7 studies	29% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	23% ± 12%	Explore
basal cell	7 studies	35% ± 17%	Explore
macrophage	7 studies	22% ± 8%	Explore
smooth muscle cell	7 studies	18% ± 2%	Explore
epithelial cell	7 studies	37% ± 18%	Explore
plasmacytoid dendritic cell	7 studies	26% ± 8%	Explore
pericyte	6 studies	18% ± 4%	Explore
plasmablast	5 studies	43% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	32% ± 11%	Explore
abnormal cell	5 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
exhausted T cell	4 studies	30% ± 6%	Explore
myofibroblast cell	4 studies	20% ± 3%	Explore
connective tissue cell	4 studies	21% ± 6%	Explore
mesothelial cell	4 studies	25% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	23% ± 2%	Explore
oligodendrocyte	4 studies	16% ± 1%	Explore
mucosal invariant T cell	4 studies	16% ± 1%	Explore
deuterosomal cell	3 studies	29% ± 3%	Explore
pancreatic A cell	3 studies	25% ± 5%	Explore
type B pancreatic cell	3 studies	36% ± 4%	Explore
hematopoietic precursor cell	3 studies	38% ± 19%	Explore
non-classical monocyte	3 studies	25% ± 3%	Explore
lymphocyte	3 studies	29% ± 10%	Explore
myeloid cell	3 studies	23% ± 11%	Explore
club cell	3 studies	25% ± 5%	Explore
retina horizontal cell	3 studies	24% ± 8%	Explore
Mueller cell	3 studies	26% ± 3%	Explore
erythroblast	3 studies	33% ± 21%	Explore
T follicular helper cell	3 studies	16% ± 1%	Explore
GABAergic neuron	3 studies	30% ± 2%	Explore
glutamatergic neuron	3 studies	41% ± 5%	Explore
dendritic cell	3 studies	41% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	36% ± 19%	Explore
enteroendocrine cell	3 studies	29% ± 15%	Explore
secretory cell	3 studies	38% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	18% ± 2%	Explore
double negative thymocyte	3 studies	30% ± 13%	Explore
memory B cell	3 studies	19% ± 5%	Explore
astrocyte	3 studies	19% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	29% ± 15%	Explore
peripheral blood	7 studies	21% ± 5%	Explore
brain	5 studies	27% ± 8%	Explore
liver	5 studies	25% ± 18%	Explore
pancreas	3 studies	28% ± 3%	Explore
bone marrow	3 studies	17% ± 1%	Explore
eye	3 studies	23% ± 5%	Explore
thymus	3 studies	36% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	846.09	1445 / 1445	100%	17.01	183 / 183
liver	100%	526.89	226 / 226	100%	19.82	406 / 406
lung	100%	767.62	578 / 578	100%	21.60	1155 / 1155
ovary	100%	1156.85	180 / 180	100%	29.49	430 / 430
uterus	100%	1028.02	170 / 170	100%	39.98	459 / 459
thymus	100%	2142.36	653 / 653	100%	31.11	604 / 605
breast	100%	820.47	459 / 459	100%	26.34	1116 / 1118
brain	100%	705.10	2637 / 2642	100%	16.63	705 / 705
prostate	100%	926.83	245 / 245	100%	21.13	501 / 502
skin	100%	819.94	1806 / 1809	100%	21.83	471 / 472
bladder	100%	1010.38	21 / 21	99%	25.42	501 / 504
adrenal gland	100%	1038.27	258 / 258	99%	16.63	228 / 230
stomach	100%	733.87	359 / 359	99%	15.48	283 / 286
pancreas	99%	404.48	325 / 328	99%	19.10	177 / 178
intestine	100%	758.11	966 / 966	98%	15.31	517 / 527
kidney	100%	776.33	89 / 89	97%	15.30	875 / 901
blood vessel	100%	880.83	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	39.18	29 / 29
spleen	100%	897.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.25	45 / 45
ureter	0%	0	0 / 0	100%	19.40	1 / 1
adipose	100%	727.38	1203 / 1204	0%	0	0 / 0
heart	97%	434.64	836 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	11.54	76 / 80
muscle	81%	184.84	652 / 803	0%	0	0 / 0
peripheral blood	67%	624.68	618 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001501	Biological process	skeletal system development
GO_0060271	Biological process	cilium assembly
GO_0015031	Biological process	protein transport
GO_0001822	Biological process	kidney development
GO_0007224	Biological process	smoothened signaling pathway
GO_0007283	Biological process	spermatogenesis
GO_0030324	Biological process	lung development
GO_0035720	Biological process	intraciliary anterograde transport
GO_0070986	Biological process	left/right axis specification
GO_0030154	Biological process	cell differentiation
GO_0007507	Biological process	heart development
GO_0097542	Cellular component	ciliary tip
GO_0005813	Cellular component	centrosome
GO_0005929	Cellular component	cilium
GO_0030992	Cellular component	intraciliary transport particle B
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	IFT25
Protein name	Intraflagellar transport 25 Chromosome 1 open reading frame 41, isoform CRA_b (Intraflagellar transport 25) Intraflagellar transport protein 25 homolog (Heat shock protein beta-11) (Hspb11) (Placental protein 25) (PP25)
Synonyms	HSPC034 C1orf41 HSPB11 hCG_1780523
Description	FUNCTION: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). .
Accessions	Q9Y547 A6NG08 X6R7Y7 ENST00000194214.10 ENST00000371377.3 ENST00000371378.6 ENST00000371376.1 A6NIR2

IFT25 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review