ICAM3 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	37 studies	41% ± 13%	Explore
CD8-positive, alpha-beta T cell	33 studies	38% ± 14%	Explore
B cell	32 studies	36% ± 12%	Explore
CD4-positive, alpha-beta T cell	31 studies	40% ± 13%	Explore
regulatory T cell	27 studies	44% ± 14%	Explore
T cell	26 studies	35% ± 10%	Explore
non-classical monocyte	21 studies	41% ± 18%	Explore
memory B cell	20 studies	36% ± 10%	Explore
classical monocyte	19 studies	37% ± 17%	Explore
naive B cell	19 studies	31% ± 10%	Explore
conventional dendritic cell	18 studies	36% ± 14%	Explore
gamma-delta T cell	18 studies	40% ± 13%	Explore
mature NK T cell	18 studies	42% ± 12%	Explore
plasma cell	16 studies	41% ± 17%	Explore
mucosal invariant T cell	15 studies	40% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	38% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	44% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	47% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	41% ± 13%	Explore
monocyte	12 studies	34% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	37% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	40% ± 14%	Explore
dendritic cell	10 studies	39% ± 19%	Explore
neutrophil	10 studies	40% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	44% ± 19%	Explore
innate lymphoid cell	8 studies	35% ± 13%	Explore
T follicular helper cell	8 studies	42% ± 6%	Explore
plasmablast	7 studies	38% ± 22%	Explore
plasmacytoid dendritic cell	7 studies	22% ± 8%	Explore
hematopoietic stem cell	7 studies	50% ± 8%	Explore
CD4-positive helper T cell	6 studies	26% ± 5%	Explore
hematopoietic precursor cell	6 studies	47% ± 25%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	44% ± 10%	Explore
leukocyte	6 studies	24% ± 4%	Explore
IgA plasma cell	6 studies	23% ± 4%	Explore
IgG plasma cell	6 studies	26% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	49% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	38% ± 14%	Explore
exhausted T cell	5 studies	54% ± 13%	Explore
T-helper 17 cell	5 studies	40% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	33% ± 14%	Explore
immature B cell	4 studies	49% ± 10%	Explore
epithelial cell	4 studies	22% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	62% ± 6%	Explore
mast cell	3 studies	23% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	44% ± 16%	Explore
common myeloid progenitor	3 studies	38% ± 31%	Explore
intraepithelial lymphocyte	3 studies	35% ± 11%	Explore
germinal center B cell	3 studies	25% ± 5%	Explore
intermediate monocyte	3 studies	52% ± 24%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 20%	Explore
T-helper 1 cell	3 studies	47% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	45% ± 10%	Explore
double negative thymocyte	3 studies	50% ± 2%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	37% ± 13%	Explore
lung	4 studies	23% ± 3%	Explore
liver	4 studies	29% ± 11%	Explore
intestine	3 studies	22% ± 5%	Explore
lymph node	3 studies	35% ± 4%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	261.95	578 / 578	70%	2.13	807 / 1155
stomach	72%	47.79	260 / 359	49%	1.43	140 / 286
breast	63%	30.63	291 / 459	45%	1.26	508 / 1118
intestine	60%	138.61	575 / 966	45%	1.15	235 / 527
thymus	62%	48.95	406 / 653	38%	2.11	229 / 605
lymph node	0%	0	0 / 0	100%	21.20	29 / 29
peripheral blood	100%	6410.20	929 / 929	0%	0	0 / 0
spleen	100%	1470.08	241 / 241	0%	0	0 / 0
kidney	45%	36.13	40 / 89	54%	1.31	486 / 901
bladder	57%	39.43	12 / 21	38%	1.04	189 / 504
liver	70%	31.74	158 / 226	13%	0.31	54 / 406
adipose	81%	63.41	977 / 1204	0%	0	0 / 0
skin	31%	11.07	564 / 1809	45%	1.84	213 / 472
prostate	58%	32.17	141 / 245	16%	0.30	82 / 502
uterus	41%	17.03	69 / 170	31%	0.69	142 / 459
tonsil	0%	0	0 / 0	71%	3.08	32 / 45
pancreas	8%	3.17	26 / 328	54%	1.80	96 / 178
esophagus	37%	19.96	539 / 1445	13%	0.37	24 / 183
heart	32%	13.09	276 / 861	0%	0	0 / 0
blood vessel	30%	18.92	397 / 1335	0%	0	0 / 0
ovary	12%	4.48	21 / 180	14%	0.26	62 / 430
adrenal gland	17%	5.07	43 / 258	2%	0.02	4 / 230
brain	10%	3.27	263 / 2642	6%	0.10	42 / 705
eye	0%	0	0 / 0	8%	0.17	6 / 80
muscle	2%	0.49	13 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1