HSD17B11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	28 studies	24% ± 7%	Explore
natural killer cell	26 studies	22% ± 6%	Explore
endothelial cell	25 studies	26% ± 10%	Explore
classical monocyte	21 studies	35% ± 11%	Explore
non-classical monocyte	20 studies	30% ± 14%	Explore
monocyte	18 studies	29% ± 12%	Explore
fibroblast	18 studies	25% ± 9%	Explore
conventional dendritic cell	18 studies	29% ± 13%	Explore
CD4-positive, alpha-beta T cell	17 studies	21% ± 5%	Explore
B cell	16 studies	23% ± 6%	Explore
CD8-positive, alpha-beta T cell	14 studies	21% ± 5%	Explore
naive B cell	12 studies	21% ± 3%	Explore
mast cell	11 studies	25% ± 10%	Explore
gamma-delta T cell	11 studies	25% ± 6%	Explore
memory B cell	11 studies	21% ± 3%	Explore
dendritic cell	11 studies	26% ± 17%	Explore
endothelial cell of vascular tree	11 studies	30% ± 12%	Explore
T cell	11 studies	22% ± 4%	Explore
capillary endothelial cell	10 studies	23% ± 3%	Explore
epithelial cell	10 studies	42% ± 18%	Explore
type I pneumocyte	9 studies	31% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	25% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 4%	Explore
mature NK T cell	9 studies	21% ± 5%	Explore
vein endothelial cell	9 studies	24% ± 5%	Explore
myeloid cell	9 studies	27% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	25% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	26% ± 5%	Explore
progenitor cell	8 studies	31% ± 16%	Explore
endothelial cell of artery	8 studies	22% ± 3%	Explore
enterocyte	8 studies	48% ± 21%	Explore
mucosal invariant T cell	8 studies	23% ± 5%	Explore
regulatory T cell	8 studies	21% ± 5%	Explore
neutrophil	7 studies	25% ± 9%	Explore
myofibroblast cell	7 studies	17% ± 1%	Explore
microglial cell	7 studies	30% ± 10%	Explore
smooth muscle cell	6 studies	17% ± 1%	Explore
hematopoietic stem cell	6 studies	45% ± 13%	Explore
pericyte	6 studies	21% ± 4%	Explore
connective tissue cell	6 studies	18% ± 2%	Explore
ciliated cell	6 studies	24% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 9%	Explore
plasmacytoid dendritic cell	6 studies	23% ± 5%	Explore
hematopoietic precursor cell	5 studies	38% ± 17%	Explore
mononuclear phagocyte	5 studies	32% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	26% ± 5%	Explore
goblet cell	5 studies	29% ± 6%	Explore
leukocyte	5 studies	23% ± 5%	Explore
innate lymphoid cell	5 studies	25% ± 8%	Explore
alveolar macrophage	5 studies	29% ± 6%	Explore
type II pneumocyte	5 studies	25% ± 6%	Explore
hepatocyte	5 studies	47% ± 24%	Explore
endothelial cell of lymphatic vessel	5 studies	21% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	21% ± 4%	Explore
intestinal crypt stem cell	4 studies	41% ± 9%	Explore
transit amplifying cell	4 studies	34% ± 11%	Explore
pro-B cell	4 studies	27% ± 5%	Explore
basal cell	4 studies	28% ± 6%	Explore
club cell	4 studies	34% ± 20%	Explore
T follicular helper cell	4 studies	20% ± 5%	Explore
abnormal cell	3 studies	30% ± 10%	Explore
common myeloid progenitor	3 studies	41% ± 30%	Explore
lymphocyte	3 studies	18% ± 2%	Explore
intermediate monocyte	3 studies	45% ± 16%	Explore
GABAergic neuron	3 studies	23% ± 3%	Explore
glutamatergic neuron	3 studies	35% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 9%	Explore
granulocyte	3 studies	42% ± 5%	Explore
granulocyte monocyte progenitor cell	3 studies	23% ± 4%	Explore
enteroendocrine cell	3 studies	29% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 4%	Explore
secretory cell	3 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	22% ± 4%	Explore
double negative thymocyte	3 studies	27% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	30% ± 7%	Explore
intestine	11 studies	24% ± 12%	Explore
lung	10 studies	23% ± 5%	Explore
brain	6 studies	23% ± 6%	Explore
kidney	5 studies	17% ± 1%	Explore
liver	5 studies	30% ± 8%	Explore
bone marrow	3 studies	19% ± 2%	Explore
lymph node	3 studies	24% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	5206.04	226 / 226	100%	174.20	405 / 406
intestine	100%	6355.89	966 / 966	99%	113.33	523 / 527
lung	100%	4292.40	577 / 578	98%	83.05	1132 / 1155
adrenal gland	100%	4481.01	258 / 258	98%	68.18	225 / 230
bladder	100%	3483.57	21 / 21	98%	89.02	493 / 504
prostate	99%	2144.96	242 / 245	99%	76.29	495 / 502
ovary	100%	3387.08	180 / 180	96%	47.08	414 / 430
pancreas	97%	2798.13	318 / 328	99%	106.06	176 / 178
stomach	94%	1988.51	337 / 359	99%	98.42	284 / 286
thymus	98%	1641.31	639 / 653	94%	28.68	571 / 605
kidney	100%	2104.03	89 / 89	92%	66.52	831 / 901
skin	89%	1530.97	1618 / 1809	98%	69.74	461 / 472
brain	86%	1109.88	2279 / 2642	99%	43.10	701 / 705
esophagus	88%	2018.42	1269 / 1445	87%	59.63	160 / 183
breast	100%	4272.32	459 / 459	74%	23.74	822 / 1118
uterus	99%	4654.21	169 / 170	74%	36.14	339 / 459
adipose	100%	5094.44	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2822.89	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	38.06	29 / 29
spleen	100%	2517.39	241 / 241	0%	0	0 / 0
peripheral blood	100%	7290.06	926 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	61.26	77 / 80
heart	86%	1072.32	740 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	64%	18.34	29 / 45
muscle	48%	464.43	388 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006703	Biological process	estrogen biosynthetic process
GO_0006710	Biological process	androgen catabolic process
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005811	Cellular component	lipid droplet
GO_0005737	Cellular component	cytoplasm
GO_0004303	Molecular function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO_0016229	Molecular function	steroid dehydrogenase activity
GO_0005515	Molecular function	protein binding
GO_0016616	Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

IV. Literature review

[source]

Gene name	HSD17B11
Protein name	Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (Dehydrogenase/reductase SDR family member 8) Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2)
Synonyms	SDR16C2 DHRS8 PSEC0029 UNQ207/PRO233 PAN1B
Description	FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Accessions	Q8NBQ5 ENST00000358290.9 ENST00000507286.1 D6RCD0

HSD17B11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review