GSTO1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	34% ± 13%	Explore
macrophage	33 studies	50% ± 19%	Explore
fibroblast	33 studies	32% ± 17%	Explore
classical monocyte	26 studies	53% ± 14%	Explore
conventional dendritic cell	26 studies	41% ± 14%	Explore
pericyte	25 studies	31% ± 15%	Explore
smooth muscle cell	24 studies	25% ± 9%	Explore
non-classical monocyte	24 studies	53% ± 13%	Explore
natural killer cell	22 studies	24% ± 8%	Explore
T cell	20 studies	22% ± 6%	Explore
monocyte	20 studies	49% ± 12%	Explore
basal cell	20 studies	34% ± 14%	Explore
CD4-positive, alpha-beta T cell	19 studies	26% ± 14%	Explore
dendritic cell	18 studies	38% ± 23%	Explore
regulatory T cell	18 studies	26% ± 10%	Explore
epithelial cell	17 studies	39% ± 21%	Explore
B cell	16 studies	19% ± 6%	Explore
mast cell	15 studies	30% ± 9%	Explore
endothelial cell of lymphatic vessel	15 studies	42% ± 13%	Explore
CD8-positive, alpha-beta T cell	15 studies	29% ± 12%	Explore
myeloid cell	14 studies	43% ± 20%	Explore
myofibroblast cell	13 studies	26% ± 8%	Explore
connective tissue cell	13 studies	34% ± 13%	Explore
capillary endothelial cell	12 studies	31% ± 7%	Explore
platelet	11 studies	45% ± 15%	Explore
endothelial cell of artery	11 studies	30% ± 9%	Explore
endothelial cell of vascular tree	10 studies	31% ± 10%	Explore
gamma-delta T cell	10 studies	24% ± 15%	Explore
plasmacytoid dendritic cell	9 studies	27% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	24% ± 8%	Explore
mature NK T cell	9 studies	19% ± 4%	Explore
vein endothelial cell	9 studies	25% ± 6%	Explore
alveolar macrophage	8 studies	60% ± 28%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	22% ± 5%	Explore
progenitor cell	8 studies	44% ± 20%	Explore
abnormal cell	8 studies	27% ± 8%	Explore
goblet cell	8 studies	27% ± 14%	Explore
neutrophil	7 studies	28% ± 8%	Explore
leukocyte	7 studies	34% ± 11%	Explore
epithelial cell of proximal tubule	7 studies	35% ± 11%	Explore
enterocyte	7 studies	41% ± 14%	Explore
memory B cell	7 studies	18% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	18% ± 4%	Explore
ciliated cell	7 studies	39% ± 11%	Explore
erythrocyte	7 studies	36% ± 21%	Explore
hematopoietic precursor cell	6 studies	42% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	22% ± 2%	Explore
mononuclear phagocyte	6 studies	46% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
kidney loop of Henle epithelial cell	6 studies	26% ± 8%	Explore
renal alpha-intercalated cell	6 studies	36% ± 10%	Explore
megakaryocyte	6 studies	69% ± 24%	Explore
hematopoietic stem cell	6 studies	35% ± 14%	Explore
innate lymphoid cell	6 studies	26% ± 15%	Explore
plasma cell	6 studies	32% ± 12%	Explore
mucosal invariant T cell	6 studies	18% ± 3%	Explore
secretory cell	6 studies	31% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	34% ± 11%	Explore
naive B cell	5 studies	19% ± 4%	Explore
enteroendocrine cell	5 studies	36% ± 13%	Explore
transit amplifying cell	5 studies	28% ± 8%	Explore
erythroblast	5 studies	44% ± 21%	Explore
intermediate monocyte	5 studies	60% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	29% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	30% ± 12%	Explore
exhausted T cell	4 studies	34% ± 13%	Explore
glomerular endothelial cell	4 studies	35% ± 8%	Explore
intestinal crypt stem cell	4 studies	33% ± 13%	Explore
retinal ganglion cell	4 studies	51% ± 27%	Explore
pro-B cell	4 studies	23% ± 1%	Explore
microglial cell	4 studies	26% ± 9%	Explore
adventitial cell	4 studies	32% ± 7%	Explore
inflammatory macrophage	4 studies	43% ± 13%	Explore
endothelial cell of sinusoid	4 studies	30% ± 10%	Explore
oligodendrocyte	4 studies	22% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	36% ± 10%	Explore
hepatocyte	4 studies	56% ± 29%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	30% ± 16%	Explore
plasmablast	3 studies	37% ± 12%	Explore
pancreatic A cell	3 studies	41% ± 4%	Explore
type B pancreatic cell	3 studies	53% ± 4%	Explore
monocyte-derived dendritic cell	3 studies	45% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	30% ± 3%	Explore
extravillous trophoblast	3 studies	22% ± 5%	Explore
placental villous trophoblast	3 studies	41% ± 23%	Explore
lymphocyte	3 studies	38% ± 5%	Explore
club cell	3 studies	29% ± 7%	Explore
type II pneumocyte	3 studies	33% ± 16%	Explore
astrocyte	3 studies	22% ± 7%	Explore
retinal cone cell	3 studies	29% ± 6%	Explore
tissue-resident macrophage	3 studies	38% ± 14%	Explore
rod bipolar cell	3 studies	28% ± 10%	Explore
neuron	3 studies	28% ± 8%	Explore
granulocyte	3 studies	42% ± 14%	Explore
type I pneumocyte	3 studies	31% ± 12%	Explore
GABAergic neuron	3 studies	28% ± 7%	Explore
glutamatergic neuron	3 studies	35% ± 10%	Explore
pancreatic ductal cell	3 studies	62% ± 8%	Explore
glial cell	3 studies	32% ± 14%	Explore
melanocyte	3 studies	29% ± 13%	Explore
T-helper 17 cell	3 studies	35% ± 24%	Explore
T follicular helper cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	35% ± 14%	Explore
peripheral blood	17 studies	29% ± 10%	Explore
intestine	10 studies	27% ± 10%	Explore
kidney	8 studies	31% ± 8%	Explore
liver	8 studies	34% ± 21%	Explore
brain	7 studies	26% ± 4%	Explore
uterus	5 studies	30% ± 13%	Explore
pancreas	4 studies	41% ± 13%	Explore
eye	4 studies	23% ± 5%	Explore
placenta	4 studies	39% ± 20%	Explore
bone marrow	4 studies	29% ± 11%	Explore
lymph node	4 studies	28% ± 16%	Explore
breast	4 studies	21% ± 2%	Explore
adrenal gland	3 studies	23% ± 1%	Explore
prostate	3 studies	31% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	8499.14	226 / 226	100%	431.98	406 / 406
skin	100%	4380.45	1807 / 1809	100%	385.00	472 / 472
kidney	100%	4773.44	89 / 89	100%	185.63	900 / 901
thymus	100%	3539.81	652 / 653	100%	225.76	604 / 605
stomach	100%	2931.70	359 / 359	100%	153.06	285 / 286
intestine	100%	3498.10	966 / 966	100%	186.57	525 / 527
lung	100%	6160.30	578 / 578	100%	203.73	1150 / 1155
adrenal gland	100%	5519.05	258 / 258	100%	174.24	229 / 230
uterus	100%	3082.11	170 / 170	100%	182.97	457 / 459
brain	99%	3045.04	2627 / 2642	100%	122.20	705 / 705
esophagus	100%	3656.72	1444 / 1445	99%	135.69	182 / 183
ovary	100%	3107.78	180 / 180	99%	97.27	426 / 430
bladder	100%	3922.33	21 / 21	99%	195.48	499 / 504
breast	100%	3505.23	459 / 459	99%	142.01	1104 / 1118
prostate	100%	3329.69	244 / 245	99%	124.12	496 / 502
pancreas	97%	1775.75	317 / 328	99%	198.91	177 / 178
eye	0%	0	0 / 0	100%	349.50	80 / 80
lymph node	0%	0	0 / 0	100%	281.21	29 / 29
spleen	100%	4184.47	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	209.74	45 / 45
ureter	0%	0	0 / 0	100%	81.81	1 / 1
blood vessel	100%	4529.60	1334 / 1335	0%	0	0 / 0
adipose	100%	3689.59	1202 / 1204	0%	0	0 / 0
peripheral blood	99%	4788.58	924 / 929	0%	0	0 / 0
muscle	99%	3185.40	796 / 803	0%	0	0 / 0
heart	99%	6290.74	850 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042178	Biological process	xenobiotic catabolic process
GO_0010880	Biological process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO_0060315	Biological process	negative regulation of ryanodine-sensitive calcium-release channel activity
GO_0014810	Biological process	positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO_0098869	Biological process	cellular oxidant detoxification
GO_0019852	Biological process	L-ascorbic acid metabolic process
GO_0071243	Biological process	cellular response to arsenic-containing substance
GO_0060316	Biological process	positive regulation of ryanodine-sensitive calcium-release channel activity
GO_0006749	Biological process	glutathione metabolic process
GO_0010881	Biological process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0005737	Cellular component	cytoplasm
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0045174	Molecular function	glutathione dehydrogenase (ascorbate) activity
GO_0050610	Molecular function	methylarsonate reductase activity
GO_0016491	Molecular function	oxidoreductase activity
GO_0005515	Molecular function	protein binding
GO_0004364	Molecular function	glutathione transferase activity

IV. Literature review

[source]

Gene name	GSTO1
Protein name	Glutathione S-transferase omega 1 Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R) Glutathione S-transferase omega (GSTO) (EC 1.20.4.2) (EC 1.8.5.1) (EC 2.5.1.18) (Glutathione-dependent dehydroascorbate reductase) (Monomethylarsonic acid reductase)
Synonyms	HEL-S-21 GSTTLP28 hCG_21844
Description	FUNCTION: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. . FUNCTION: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). . FUNCTION: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). .
Accessions	ENST00000369713.10 [P78417-1] ENST00000445155.5 Q5TA02 ENST00000369710.8 [P78417-2] ENST00000539281.5 [P78417-3] ENST00000432659.1 P78417 V9HWG9 Q5TA01

GSTO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review