GPX1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	29 studies	57% ± 19%	Explore
macrophage	27 studies	79% ± 24%	Explore
fibroblast	24 studies	47% ± 16%	Explore
T cell	19 studies	33% ± 11%	Explore
B cell	18 studies	46% ± 13%	Explore
natural killer cell	17 studies	27% ± 8%	Explore
monocyte	16 studies	76% ± 22%	Explore
CD4-positive, alpha-beta T cell	16 studies	37% ± 13%	Explore
dendritic cell	15 studies	70% ± 23%	Explore
pericyte	14 studies	39% ± 18%	Explore
epithelial cell	14 studies	62% ± 22%	Explore
conventional dendritic cell	14 studies	92% ± 7%	Explore
CD8-positive, alpha-beta T cell	14 studies	33% ± 12%	Explore
mast cell	13 studies	53% ± 26%	Explore
plasmacytoid dendritic cell	13 studies	91% ± 8%	Explore
plasma cell	12 studies	49% ± 19%	Explore
connective tissue cell	12 studies	44% ± 17%	Explore
endothelial cell of lymphatic vessel	11 studies	57% ± 17%	Explore
smooth muscle cell	11 studies	38% ± 12%	Explore
classical monocyte	11 studies	81% ± 20%	Explore
regulatory T cell	11 studies	54% ± 16%	Explore
basal cell	10 studies	59% ± 22%	Explore
myeloid cell	9 studies	80% ± 21%	Explore
myofibroblast cell	8 studies	42% ± 13%	Explore
non-classical monocyte	8 studies	65% ± 15%	Explore
abnormal cell	8 studies	46% ± 17%	Explore
ciliated cell	8 studies	61% ± 17%	Explore
type I pneumocyte	7 studies	32% ± 8%	Explore
type II pneumocyte	7 studies	60% ± 23%	Explore
microglial cell	7 studies	65% ± 29%	Explore
goblet cell	7 studies	41% ± 13%	Explore
mononuclear phagocyte	6 studies	76% ± 22%	Explore
neutrophil	6 studies	51% ± 26%	Explore
progenitor cell	6 studies	57% ± 21%	Explore
gamma-delta T cell	6 studies	36% ± 19%	Explore
memory B cell	6 studies	45% ± 12%	Explore
naive B cell	6 studies	45% ± 13%	Explore
endothelial cell of vascular tree	6 studies	56% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	29% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	33% ± 11%	Explore
capillary endothelial cell	5 studies	57% ± 15%	Explore
epithelial cell of proximal tubule	5 studies	57% ± 15%	Explore
kidney loop of Henle epithelial cell	5 studies	36% ± 11%	Explore
renal alpha-intercalated cell	5 studies	68% ± 10%	Explore
innate lymphoid cell	5 studies	54% ± 24%	Explore
intestinal crypt stem cell	5 studies	47% ± 23%	Explore
leukocyte	5 studies	63% ± 20%	Explore
mesothelial cell	5 studies	62% ± 21%	Explore
transit amplifying cell	5 studies	39% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	42% ± 15%	Explore
alveolar macrophage	4 studies	73% ± 34%	Explore
megakaryocyte	4 studies	86% ± 17%	Explore
mature NK T cell	4 studies	24% ± 10%	Explore
endothelial cell of artery	4 studies	61% ± 11%	Explore
enterocyte	4 studies	51% ± 12%	Explore
enteroendocrine cell	4 studies	47% ± 20%	Explore
vein endothelial cell	4 studies	56% ± 11%	Explore
club cell	4 studies	70% ± 4%	Explore
mucus secreting cell	4 studies	42% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	34% ± 11%	Explore
intermediate monocyte	4 studies	90% ± 2%	Explore
granulocyte	4 studies	69% ± 22%	Explore
secretory cell	4 studies	62% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	32% ± 8%	Explore
pancreatic A cell	3 studies	40% ± 9%	Explore
type B pancreatic cell	3 studies	46% ± 15%	Explore
glomerular endothelial cell	3 studies	66% ± 15%	Explore
neuron	3 studies	31% ± 12%	Explore
erythroblast	3 studies	33% ± 8%	Explore
IgG plasma cell	3 studies	23% ± 8%	Explore
T follicular helper cell	3 studies	55% ± 11%	Explore
adventitial cell	3 studies	51% ± 3%	Explore
duct epithelial cell	3 studies	67% ± 2%	Explore
ionocyte	3 studies	46% ± 2%	Explore
respiratory goblet cell	3 studies	77% ± 10%	Explore
intraepithelial lymphocyte	3 studies	31% ± 13%	Explore
endothelial cell of sinusoid	3 studies	41% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	52% ± 5%	Explore
exhausted T cell	3 studies	39% ± 5%	Explore
plasmablast	3 studies	49% ± 17%	Explore
hematopoietic precursor cell	3 studies	53% ± 33%	Explore
hepatocyte	3 studies	64% ± 23%	Explore
erythrocyte	3 studies	49% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	26% ± 2%	Explore
mucosal invariant T cell	3 studies	24% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	49% ± 15%	Explore
intestine	7 studies	40% ± 12%	Explore
kidney	7 studies	47% ± 16%	Explore
brain	7 studies	39% ± 25%	Explore
peripheral blood	7 studies	41% ± 6%	Explore
liver	5 studies	40% ± 14%	Explore
pancreas	3 studies	43% ± 10%	Explore
uterus	3 studies	55% ± 29%	Explore
adrenal gland	3 studies	32% ± 3%	Explore
bone marrow	3 studies	32% ± 19%	Explore
esophagus	3 studies	47% ± 20%	Explore
prostate	3 studies	32% ± 20%	Explore
lymph node	3 studies	53% ± 30%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	12004.70	226 / 226	100%	734.42	406 / 406
thymus	100%	7230.43	652 / 653	100%	810.67	605 / 605
uterus	100%	5642.15	170 / 170	100%	742.12	457 / 459
kidney	100%	11402.76	89 / 89	99%	806.50	895 / 901
prostate	100%	8849.92	245 / 245	99%	535.60	498 / 502
ovary	99%	4687.89	178 / 180	100%	1239.39	430 / 430
intestine	100%	6767.90	966 / 966	99%	574.31	521 / 527
bladder	100%	8788.33	21 / 21	98%	735.90	496 / 504
lung	100%	13870.28	578 / 578	98%	630.65	1136 / 1155
stomach	100%	5240.57	358 / 359	99%	513.74	282 / 286
breast	100%	12827.58	459 / 459	97%	504.12	1089 / 1118
esophagus	100%	7832.38	1445 / 1445	97%	323.59	178 / 183
skin	99%	8482.66	1797 / 1809	97%	785.96	458 / 472
adrenal gland	100%	16237.46	258 / 258	96%	410.27	221 / 230
brain	96%	4849.90	2536 / 2642	100%	751.03	705 / 705
pancreas	77%	2521.80	253 / 328	99%	681.17	177 / 178
adipose	100%	15616.25	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	589.87	80 / 80
lymph node	0%	0	0 / 0	100%	1106.82	29 / 29
peripheral blood	100%	23584.71	929 / 929	0%	0	0 / 0
spleen	100%	14863.80	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	707.90	45 / 45
ureter	0%	0	0 / 0	100%	787.44	1 / 1
blood vessel	99%	8045.48	1323 / 1335	0%	0	0 / 0
heart	96%	5081.17	826 / 861	0%	0	0 / 0
muscle	95%	4083.78	765 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0045454	Biological process	cell redox homeostasis
GO_0042542	Biological process	response to hydrogen peroxide
GO_0032355	Biological process	response to estradiol
GO_0007605	Biological process	sensory perception of sound
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0033599	Biological process	regulation of mammary gland epithelial cell proliferation
GO_0098869	Biological process	cellular oxidant detoxification
GO_0009650	Biological process	UV protection
GO_0010332	Biological process	response to gamma radiation
GO_0019372	Biological process	lipoxygenase pathway
GO_0048741	Biological process	skeletal muscle fiber development
GO_0060055	Biological process	angiogenesis involved in wound healing
GO_0090201	Biological process	negative regulation of release of cytochrome c from mitochondria
GO_0042744	Biological process	hydrogen peroxide catabolic process
GO_0033194	Biological process	response to hydroperoxide
GO_0043403	Biological process	skeletal muscle tissue regeneration
GO_1902176	Biological process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0002862	Biological process	negative regulation of inflammatory response to antigenic stimulus
GO_0051702	Biological process	biological process involved in interaction with symbiont
GO_0033197	Biological process	response to vitamin E
GO_0009609	Biological process	response to symbiotic bacterium
GO_0001885	Biological process	endothelial cell development
GO_0043534	Biological process	blood vessel endothelial cell migration
GO_0051402	Biological process	neuron apoptotic process
GO_0009725	Biological process	response to hormone
GO_0034599	Biological process	cellular response to oxidative stress
GO_0060047	Biological process	heart contraction
GO_0051450	Biological process	myoblast proliferation
GO_0048144	Biological process	fibroblast proliferation
GO_0006641	Biological process	triglyceride metabolic process
GO_0045445	Biological process	myoblast differentiation
GO_0035094	Biological process	response to nicotine
GO_1902905	Biological process	positive regulation of supramolecular fiber organization
GO_1902042	Biological process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0001659	Biological process	temperature homeostasis
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008631	Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress
GO_0040029	Biological process	epigenetic regulation of gene expression
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0010269	Biological process	response to selenium ion
GO_0042311	Biological process	vasodilation
GO_0019369	Biological process	arachidonic acid metabolic process
GO_0061136	Biological process	regulation of proteasomal protein catabolic process
GO_0006749	Biological process	glutathione metabolic process
GO_0045444	Biological process	fat cell differentiation
GO_0051593	Biological process	response to folic acid
GO_0005739	Cellular component	mitochondrion
GO_0005829	Cellular component	cytosol
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0097413	Cellular component	Lewy body
GO_0047066	Molecular function	phospholipid-hydroperoxide glutathione peroxidase activity
GO_0004602	Molecular function	glutathione peroxidase activity
GO_0005515	Molecular function	protein binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	GPX1
Protein name	Glutathione peroxidase Glutathione peroxidase 1 isoform A Glutathione peroxidase 1 (GPx-1) (GSHPx-1) (EC 1.11.1.9) (Cellular glutathione peroxidase) (Phospholipid-hydroperoxide glutathione peroxidase GPX1) (EC 1.11.1.12) Glutathione peroxidase 1 Glutathione peroxidase 1 (EC 1.11.1.9) (Cellular glutathione peroxidase)
Synonyms
Description	FUNCTION: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis . Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides . In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway . .
Accessions	ENST00000643797.2 ENST00000704375.1 [P07203-2] ENST00000704378.1 A0A994J430 ENST00000704374.1 X5DQZ7 ENST00000703796.1 ENST00000703795.1 ENST00000646881.3 ENST00000704377.1 ENST00000704376.1 ENST00000703797.1 [P07203-2] A0A994J707 A0A994J7E8 ENST00000419783.3 [P07203-1] ENST00000496791.3 A0A994J4L4 ENST00000704356.1 Q7L4Q3 X5D926 Q6NSD4 A0A7I2UQ36 A0A994J4K6 ENST00000419349.3 [P07203-2] P07203 A0A994J4E2 A0A2R8Y6B6 A0A7I2YMD7 A0A994J702

GPX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review