FUNDC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	26 studies	28% ± 13%	Explore
natural killer cell	22 studies	22% ± 7%	Explore
endothelial cell	21 studies	26% ± 11%	Explore
pericyte	20 studies	25% ± 6%	Explore
smooth muscle cell	18 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 10%	Explore
regulatory T cell	15 studies	21% ± 4%	Explore
CD8-positive, alpha-beta T cell	14 studies	22% ± 5%	Explore
B cell	14 studies	23% ± 5%	Explore
CD4-positive, alpha-beta T cell	13 studies	21% ± 5%	Explore
mast cell	12 studies	19% ± 4%	Explore
conventional dendritic cell	12 studies	26% ± 15%	Explore
naive B cell	12 studies	20% ± 3%	Explore
connective tissue cell	12 studies	27% ± 8%	Explore
memory B cell	12 studies	20% ± 3%	Explore
classical monocyte	11 studies	24% ± 7%	Explore
non-classical monocyte	11 studies	29% ± 11%	Explore
mature NK T cell	11 studies	21% ± 4%	Explore
T cell	10 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 5%	Explore
gamma-delta T cell	10 studies	26% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 4%	Explore
myofibroblast cell	9 studies	26% ± 9%	Explore
mucosal invariant T cell	9 studies	20% ± 3%	Explore
epithelial cell	9 studies	37% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
abnormal cell	8 studies	25% ± 10%	Explore
endothelial cell of vascular tree	8 studies	25% ± 4%	Explore
plasmacytoid dendritic cell	8 studies	25% ± 8%	Explore
plasma cell	7 studies	30% ± 11%	Explore
capillary endothelial cell	7 studies	20% ± 3%	Explore
ciliated cell	7 studies	30% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 7%	Explore
basal cell	7 studies	27% ± 8%	Explore
macrophage	7 studies	25% ± 8%	Explore
mesothelial cell	6 studies	25% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	19% ± 4%	Explore
plasmablast	5 studies	44% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	25% ± 3%	Explore
dendritic cell	5 studies	33% ± 19%	Explore
endothelial cell of artery	5 studies	23% ± 3%	Explore
pancreatic A cell	4 studies	42% ± 10%	Explore
kidney loop of Henle epithelial cell	4 studies	24% ± 5%	Explore
epithelial cell of proximal tubule	4 studies	24% ± 9%	Explore
retinal ganglion cell	4 studies	46% ± 28%	Explore
neuron	4 studies	35% ± 13%	Explore
retina horizontal cell	4 studies	28% ± 13%	Explore
monocyte	4 studies	20% ± 4%	Explore
innate lymphoid cell	4 studies	20% ± 2%	Explore
T follicular helper cell	4 studies	20% ± 1%	Explore
vein endothelial cell	4 studies	21% ± 2%	Explore
hematopoietic precursor cell	3 studies	31% ± 10%	Explore
type B pancreatic cell	3 studies	49% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	17% ± 2%	Explore
renal alpha-intercalated cell	3 studies	27% ± 7%	Explore
neural crest cell	3 studies	37% ± 2%	Explore
lymphocyte	3 studies	26% ± 3%	Explore
myeloid cell	3 studies	29% ± 8%	Explore
precursor B cell	3 studies	21% ± 5%	Explore
astrocyte	3 studies	32% ± 5%	Explore
retinal cone cell	3 studies	35% ± 8%	Explore
retinal rod cell	3 studies	23% ± 4%	Explore
Mueller cell	3 studies	24% ± 6%	Explore
CD4-positive helper T cell	3 studies	19% ± 3%	Explore
erythroblast	3 studies	36% ± 21%	Explore
exhausted T cell	3 studies	19% ± 2%	Explore
intermediate monocyte	3 studies	33% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
enteroendocrine cell	3 studies	28% ± 13%	Explore
goblet cell	3 studies	23% ± 7%	Explore
glial cell	3 studies	31% ± 18%	Explore
group 3 innate lymphoid cell	3 studies	21% ± 5%	Explore
erythrocyte	3 studies	36% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	23% ± 5%	Explore
double negative thymocyte	3 studies	34% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	24% ± 6%	Explore
lung	8 studies	26% ± 6%	Explore
kidney	6 studies	21% ± 5%	Explore
intestine	6 studies	22% ± 10%	Explore
eye	5 studies	24% ± 7%	Explore
pancreas	4 studies	40% ± 14%	Explore
lymph node	4 studies	22% ± 9%	Explore
breast	4 studies	18% ± 1%	Explore
uterus	3 studies	25% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3994.25	1445 / 1445	100%	12.13	183 / 183
ovary	100%	6158.21	180 / 180	100%	25.69	430 / 430
prostate	100%	4160.30	245 / 245	100%	26.12	502 / 502
stomach	100%	3223.23	359 / 359	100%	15.75	286 / 286
thymus	100%	3443.30	653 / 653	100%	23.29	604 / 605
uterus	100%	4362.35	170 / 170	100%	20.61	458 / 459
kidney	100%	4073.73	89 / 89	100%	28.79	899 / 901
brain	100%	3164.13	2635 / 2642	100%	29.17	705 / 705
breast	100%	4168.90	459 / 459	100%	23.00	1115 / 1118
pancreas	100%	4044.05	327 / 328	100%	17.61	178 / 178
lung	100%	3305.77	576 / 578	100%	19.19	1155 / 1155
skin	100%	2313.74	1805 / 1809	100%	20.30	471 / 472
intestine	100%	4020.61	966 / 966	99%	17.05	524 / 527
bladder	100%	4142.81	21 / 21	99%	17.80	500 / 504
adrenal gland	100%	4593.01	258 / 258	98%	22.71	225 / 230
liver	96%	2211.94	218 / 226	99%	14.18	402 / 406
adipose	100%	4274.97	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4336.79	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	19.76	29 / 29
muscle	100%	10517.48	803 / 803	0%	0	0 / 0
spleen	100%	2734.72	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.31	45 / 45
ureter	0%	0	0 / 0	100%	13.77	1 / 1
heart	99%	8362.17	854 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	16.65	79 / 80
peripheral blood	91%	1919.42	849 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000422	Biological process	autophagy of mitochondrion
GO_0035356	Biological process	intracellular triglyceride homeostasis
GO_0010543	Biological process	regulation of platelet activation
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0005547	Molecular function	phosphatidylinositol-3,4,5-trisphosphate binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FUNDC2
Protein name	FUN14 domain-containing protein 2 (Hepatitis C virus core-binding protein 6) Alternative protein FUNDC2 FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6)
Synonyms	HCC3 HCBP6 DC44 PD03104
Description	FUNCTION: Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways . May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes . .
Accessions	ENST00000369498.8 Q9BWH2 L0R6G9 ENST00000456179.1 H7C0K8

FUNDC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review