FAAP20 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	24 studies	27% ± 10%	Explore
natural killer cell	19 studies	24% ± 6%	Explore
CD8-positive, alpha-beta T cell	19 studies	25% ± 7%	Explore
B cell	18 studies	26% ± 8%	Explore
classical monocyte	17 studies	27% ± 9%	Explore
pericyte	17 studies	26% ± 9%	Explore
CD4-positive, alpha-beta T cell	16 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	15 studies	32% ± 11%	Explore
monocyte	15 studies	24% ± 8%	Explore
endothelial cell	15 studies	28% ± 11%	Explore
conventional dendritic cell	14 studies	29% ± 15%	Explore
macrophage	14 studies	25% ± 7%	Explore
smooth muscle cell	14 studies	28% ± 8%	Explore
T cell	13 studies	20% ± 4%	Explore
memory B cell	13 studies	21% ± 4%	Explore
naive B cell	13 studies	23% ± 4%	Explore
connective tissue cell	12 studies	30% ± 12%	Explore
epithelial cell	12 studies	32% ± 18%	Explore
regulatory T cell	12 studies	23% ± 6%	Explore
basal cell	10 studies	27% ± 12%	Explore
non-classical monocyte	10 studies	28% ± 11%	Explore
ciliated cell	9 studies	30% ± 11%	Explore
myofibroblast cell	9 studies	31% ± 8%	Explore
gamma-delta T cell	9 studies	28% ± 16%	Explore
dendritic cell	9 studies	39% ± 22%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	27% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	25% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	27% ± 7%	Explore
abnormal cell	8 studies	25% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	26% ± 9%	Explore
mature NK T cell	7 studies	22% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	24% ± 4%	Explore
mucosal invariant T cell	7 studies	21% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	26% ± 4%	Explore
myeloid cell	6 studies	26% ± 11%	Explore
T follicular helper cell	6 studies	20% ± 3%	Explore
hematopoietic precursor cell	5 studies	33% ± 13%	Explore
kidney loop of Henle epithelial cell	5 studies	19% ± 1%	Explore
progenitor cell	5 studies	24% ± 5%	Explore
epithelial cell of proximal tubule	5 studies	23% ± 4%	Explore
goblet cell	5 studies	27% ± 12%	Explore
neuron	5 studies	32% ± 14%	Explore
type II pneumocyte	5 studies	29% ± 12%	Explore
endothelial cell of vascular tree	5 studies	17% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	27% ± 4%	Explore
exhausted T cell	4 studies	31% ± 7%	Explore
endothelial cell of artery	4 studies	21% ± 6%	Explore
vein endothelial cell	4 studies	25% ± 8%	Explore
mesothelial cell	4 studies	30% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	27% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 5%	Explore
pancreatic A cell	3 studies	36% ± 11%	Explore
type B pancreatic cell	3 studies	35% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	22% ± 1%	Explore
capillary endothelial cell	3 studies	25% ± 9%	Explore
leukocyte	3 studies	26% ± 6%	Explore
neural crest cell	3 studies	24% ± 0%	Explore
retinal ganglion cell	3 studies	49% ± 26%	Explore
hematopoietic stem cell	3 studies	26% ± 5%	Explore
megakaryocyte	3 studies	23% ± 3%	Explore
precursor B cell	3 studies	24% ± 5%	Explore
plasma cell	3 studies	31% ± 8%	Explore
endothelial cell of lymphatic vessel	3 studies	25% ± 4%	Explore
immature B cell	3 studies	28% ± 7%	Explore
type I pneumocyte	3 studies	32% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	24% ± 3%	Explore
oligodendrocyte precursor cell	3 studies	22% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	28% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	37% ± 26%	Explore
enteroendocrine cell	3 studies	37% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	27% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	27% ± 8%	Explore
lung	9 studies	28% ± 11%	Explore
kidney	7 studies	20% ± 2%	Explore
intestine	5 studies	29% ± 13%	Explore
lymph node	5 studies	20% ± 7%	Explore
liver	4 studies	24% ± 12%	Explore
pancreas	3 studies	30% ± 16%	Explore
bone marrow	3 studies	20% ± 3%	Explore
brain	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1894.51	1445 / 1445	100%	12.71	183 / 183
ovary	100%	2163.46	180 / 180	100%	22.05	430 / 430
thymus	100%	2651.24	653 / 653	100%	15.64	605 / 605
brain	100%	1469.43	2638 / 2642	100%	10.77	703 / 705
uterus	100%	2708.47	170 / 170	100%	14.18	457 / 459
prostate	100%	2987.06	245 / 245	99%	17.63	499 / 502
intestine	100%	1919.47	966 / 966	99%	10.71	523 / 527
skin	100%	1774.75	1809 / 1809	99%	18.17	468 / 472
liver	100%	1399.62	226 / 226	99%	8.66	401 / 406
lung	100%	1876.31	576 / 578	99%	11.65	1140 / 1155
stomach	100%	1716.23	359 / 359	98%	10.33	281 / 286
kidney	100%	2689.15	89 / 89	98%	9.73	885 / 901
adrenal gland	100%	2282.52	258 / 258	98%	10.17	225 / 230
pancreas	100%	1052.97	328 / 328	98%	11.54	174 / 178
breast	100%	1942.76	459 / 459	97%	10.98	1089 / 1118
bladder	100%	2090.90	21 / 21	97%	13.17	490 / 504
adipose	100%	1818.79	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	19.94	80 / 80
lymph node	0%	0	0 / 0	100%	15.99	29 / 29
spleen	100%	2194.28	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	10.79	45 / 45
ureter	0%	0	0 / 0	100%	17.26	1 / 1
blood vessel	100%	2106.67	1334 / 1335	0%	0	0 / 0
heart	99%	1228.39	855 / 861	0%	0	0 / 0
peripheral blood	98%	1324.35	908 / 929	0%	0	0 / 0
muscle	97%	692.57	782 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006974	Biological process	DNA damage response
GO_0019985	Biological process	translesion synthesis
GO_0036297	Biological process	interstrand cross-link repair
GO_0043240	Cellular component	Fanconi anaemia nuclear complex
GO_0030054	Cellular component	cell junction
GO_0005694	Cellular component	chromosome
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0031593	Molecular function	polyubiquitin modification-dependent protein binding
GO_0140036	Molecular function	ubiquitin-modified protein reader activity
GO_0070530	Molecular function	K63-linked polyubiquitin modification-dependent protein binding
GO_0005515	Molecular function	protein binding
GO_0043130	Molecular function	ubiquitin binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	FAAP20
Protein name	FA core complex associated protein 20 Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa)
Synonyms	C1orf86 FP7162
Description	FUNCTION: Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. .
Accessions	H7C3A6 ENST00000378546.9 [Q6NZ36-1] Q6NZ36 F6S8H2 ENST00000440825.6 ENST00000400918.7 [Q6NZ36-5] ENST00000420515.1 ENST00000400919.7 ENST00000414253.5 [Q6NZ36-4] ENST00000428120.5 H7C361 H7C2E6 ENST00000378543.2 [Q6NZ36-6]

FAAP20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review