EPS15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001921Biological processpositive regulation of receptor recycling
GO_0006897Biological processendocytosis
GO_0098884Biological processpostsynaptic neurotransmitter receptor internalization
GO_0032456Biological processendocytic recycling
GO_0046718Biological processsymbiont entry into host cell
GO_0048268Biological processclathrin coat assembly
GO_0016197Biological processendosomal transport
GO_0016050Biological processvesicle organization
GO_0019065Biological processreceptor-mediated endocytosis of virus by host cell
GO_0015031Biological processprotein transport
GO_0042127Biological processregulation of cell population proliferation
GO_0006895Biological processGolgi to endosome transport
GO_0016324Cellular componentapical plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0098794Cellular componentpostsynapse
GO_0009925Cellular componentbasal plasma membrane
GO_0005829Cellular componentcytosol
GO_0030132Cellular componentclathrin coat of coated pit
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005905Cellular componentclathrin-coated pit
GO_0016235Cellular componentaggresome
GO_0045296Molecular functioncadherin binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameEPS15
Protein nameEpidermal growth factor receptor pathway substrate 15
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
KMT2A
SynonymsKMT2A
AF1P
fusion
DescriptionFUNCTION: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. .

AccessionsENST00000706288.1
ENST00000706287.1
ENST00000706293.1
B1AUU8
ENST00000493793.2 [P42566-2]
A0A994J841
ENST00000371730.6
ENST00000706292.1
A0A994J7R8
ENST00000465467.1
A0A994J5J3
A0A994J5W4
P42566
ENST00000371733.8 [P42566-1]
ENST00000706291.1
A0A994J5A3
A0A4D6WHI2
S4R3U1