EIF4G1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	24 studies	24% ± 8%	Explore
macrophage	15 studies	20% ± 5%	Explore
classical monocyte	14 studies	24% ± 9%	Explore
epithelial cell	13 studies	32% ± 19%	Explore
CD8-positive, alpha-beta T cell	13 studies	21% ± 9%	Explore
natural killer cell	11 studies	23% ± 10%	Explore
fibroblast	11 studies	22% ± 7%	Explore
basal cell	11 studies	27% ± 10%	Explore
ciliated cell	9 studies	30% ± 8%	Explore
plasmacytoid dendritic cell	9 studies	22% ± 7%	Explore
endothelial cell of lymphatic vessel	8 studies	22% ± 4%	Explore
smooth muscle cell	8 studies	18% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	17% ± 2%	Explore
endothelial cell of artery	8 studies	20% ± 3%	Explore
T cell	7 studies	20% ± 8%	Explore
plasmablast	7 studies	40% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	19% ± 3%	Explore
club cell	7 studies	26% ± 11%	Explore
mucosal invariant T cell	7 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 5%	Explore
vein endothelial cell	7 studies	21% ± 4%	Explore
gamma-delta T cell	7 studies	24% ± 9%	Explore
monocyte	6 studies	23% ± 5%	Explore
type I pneumocyte	6 studies	33% ± 10%	Explore
type II pneumocyte	6 studies	26% ± 11%	Explore
hematopoietic precursor cell	6 studies	19% ± 3%	Explore
plasma cell	6 studies	29% ± 14%	Explore
respiratory goblet cell	6 studies	33% ± 14%	Explore
conventional dendritic cell	6 studies	28% ± 14%	Explore
non-classical monocyte	6 studies	23% ± 7%	Explore
dendritic cell	6 studies	31% ± 15%	Explore
capillary endothelial cell	6 studies	21% ± 5%	Explore
CD4-positive, alpha-beta T cell	6 studies	24% ± 15%	Explore
endothelial cell of vascular tree	6 studies	21% ± 3%	Explore
goblet cell	6 studies	27% ± 6%	Explore
secretory cell	5 studies	32% ± 9%	Explore
transit amplifying cell	5 studies	22% ± 4%	Explore
pericyte	5 studies	18% ± 3%	Explore
abnormal cell	5 studies	31% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	18% ± 2%	Explore
regulatory T cell	5 studies	24% ± 13%	Explore
naive B cell	5 studies	18% ± 2%	Explore
myofibroblast cell	4 studies	21% ± 3%	Explore
myeloid cell	4 studies	27% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	22% ± 4%	Explore
B cell	4 studies	18% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 2%	Explore
ionocyte	3 studies	30% ± 7%	Explore
squamous epithelial cell	3 studies	41% ± 21%	Explore
pancreatic A cell	3 studies	31% ± 5%	Explore
type B pancreatic cell	3 studies	30% ± 9%	Explore
common myeloid progenitor	3 studies	22% ± 4%	Explore
exhausted T cell	3 studies	16% ± 1%	Explore
innate lymphoid cell	3 studies	16% ± 0%	Explore
muscle cell	3 studies	23% ± 4%	Explore
GABAergic neuron	3 studies	26% ± 9%	Explore
glutamatergic neuron	3 studies	32% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
connective tissue cell	3 studies	17% ± 1%	Explore
granulocyte monocyte progenitor cell	3 studies	21% ± 1%	Explore
enteroendocrine cell	3 studies	26% ± 7%	Explore
erythrocyte	3 studies	34% ± 14%	Explore
erythroblast	3 studies	33% ± 7%	Explore
astrocyte	3 studies	23% ± 5%	Explore
mature NK T cell	3 studies	16% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	16% ± 0%	Explore
hepatocyte	3 studies	47% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	10 studies	22% ± 5%	Explore
peripheral blood	8 studies	22% ± 5%	Explore
brain	5 studies	23% ± 5%	Explore
pancreas	3 studies	33% ± 8%	Explore
intestine	3 studies	22% ± 5%	Explore
liver	3 studies	32% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	27032.72	1445 / 1445	100%	260.14	183 / 183
skin	100%	34029.95	1809 / 1809	100%	214.29	472 / 472
breast	100%	20661.81	459 / 459	100%	196.57	1117 / 1118
intestine	100%	21897.11	966 / 966	100%	175.29	526 / 527
uterus	100%	18060.86	170 / 170	100%	229.00	458 / 459
lung	100%	22243.66	578 / 578	100%	255.50	1152 / 1155
prostate	100%	19209.86	245 / 245	99%	208.85	499 / 502
ovary	100%	15983.51	180 / 180	99%	172.64	427 / 430
stomach	100%	18857.59	359 / 359	99%	172.67	284 / 286
bladder	100%	22127.81	21 / 21	99%	189.63	500 / 504
thymus	100%	22645.61	653 / 653	99%	135.85	600 / 605
pancreas	100%	16096.90	328 / 328	99%	146.41	176 / 178
liver	100%	21663.40	226 / 226	99%	132.25	400 / 406
kidney	100%	15734.48	89 / 89	97%	111.95	877 / 901
brain	98%	9926.35	2591 / 2642	99%	119.52	699 / 705
adrenal gland	100%	26466.43	258 / 258	93%	102.07	215 / 230
adipose	100%	22023.53	1204 / 1204	0%	0	0 / 0
blood vessel	100%	19097.87	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	160.25	29 / 29
muscle	100%	52913.63	803 / 803	0%	0	0 / 0
spleen	100%	17757.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	289.03	45 / 45
ureter	0%	0	0 / 0	100%	82.52	1 / 1
eye	0%	0	0 / 0	99%	123.96	79 / 80
heart	97%	17426.67	832 / 861	0%	0	0 / 0
peripheral blood	67%	9289.33	627 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0097009	Biological process	energy homeostasis
GO_1904377	Biological process	positive regulation of protein localization to cell periphery
GO_0030324	Biological process	lung development
GO_0036493	Biological process	positive regulation of translation in response to endoplasmic reticulum stress
GO_1905606	Biological process	regulation of presynapse assembly
GO_0051247	Biological process	positive regulation of protein metabolic process
GO_0030307	Biological process	positive regulation of cell growth
GO_0035278	Biological process	miRNA-mediated gene silencing by inhibition of translation
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0006412	Biological process	translation
GO_0006413	Biological process	translational initiation
GO_0045471	Biological process	response to ethanol
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_1905612	Biological process	positive regulation of mRNA cap binding
GO_0010801	Biological process	negative regulation of peptidyl-threonine phosphorylation
GO_0031669	Biological process	cellular response to nutrient levels
GO_0030182	Biological process	neuron differentiation
GO_1905537	Biological process	positive regulation of eukaryotic translation initiation factor 4F complex assembly
GO_0006446	Biological process	regulation of translational initiation
GO_0009059	Biological process	macromolecule biosynthetic process
GO_0002191	Biological process	cap-dependent translational initiation
GO_0010507	Biological process	negative regulation of autophagy
GO_0001662	Biological process	behavioral fear response
GO_0080135	Biological process	regulation of cellular response to stress
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0005840	Cellular component	ribosome
GO_0016020	Cellular component	membrane
GO_0098794	Cellular component	postsynapse
GO_0016281	Cellular component	eukaryotic translation initiation factor 4F complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005634	Cellular component	nucleus
GO_0008135	Molecular function	translation factor activity, RNA binding
GO_0031369	Molecular function	translation initiation factor binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0003743	Molecular function	translation initiation factor activity
GO_0003729	Molecular function	mRNA binding
GO_0008190	Molecular function	eukaryotic initiation factor 4E binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	EIF4G1
Protein name	eIF4G1 protein eIF4G1 variant protein Eukaryotic translation initiation factor 4 gamma 1 Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) Eukaryotic translation initiation factor 4 gamma, 1 (eIF4G1 protein)
Synonyms	EIF4F protein EIF4GI variant EIF4G
Description	FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome . Exists in two complexes, either with EIF1 or with EIF4E (mutually exclusive) . Together with EIF1, is required for leaky scanning, in particular for avoiding cap-proximal start codon . Together with EIF4E, antagonizes the scanning promoted by EIF1-EIF4G1 and locates the start codon (through a TISU element) without scanning . As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation . .
Accessions	ENST00000392537.6 [Q04637-4] C9J6B6 ENST00000414031.5 [Q04637-3] C9JIH5 F8WB97 ENST00000676206.1 A0A7I2Y1C3 C9JF13 C9JWH7 ENST00000422614.5 ENST00000434061.6 [Q04637-7] C9JWH9 C9J2Z7 ENST00000342981.8 [Q04637-8] Q4LE58 ENST00000427845.5 ENST00000427607.5 ENST00000424196.5 [Q04637-9] ENST00000676453.1 ENST00000421110.5 A0A6Q8PG29 ENST00000455679.5 ENST00000428387.5 ENST00000442406.5 E9PGM1 ENST00000448284.1 C9JWW9 Q04637 ENST00000346169.7 [Q04637-1] ENST00000440448.5 B2RU10 Q96I65 C9J556 ENST00000413967.5 ENST00000456033.5 H7C0V6 ENST00000350481.9 [Q04637-5] ENST00000444134.5 B2RU06 ENST00000435046.7 E7EX73 C9JHW9 C9K073 ENST00000427141.6 ENST00000457456.5 ENST00000441154.5 ENST00000382330.7 [Q04637-9] A0A6Q8PFB2 E7EUU4 ENST00000426123.5 F8WCF2 ENST00000411531.5 C9JSU8 ENST00000444861.5 ENST00000450424.5 H7C044 ENST00000352767.7 [Q04637-9] C9J987

EIF4G1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review