DNAJC7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	31 studies	24% ± 9%	Explore
endothelial cell	29 studies	25% ± 9%	Explore
natural killer cell	28 studies	24% ± 8%	Explore
macrophage	25 studies	23% ± 8%	Explore
classical monocyte	23 studies	28% ± 12%	Explore
conventional dendritic cell	21 studies	29% ± 15%	Explore
fibroblast	20 studies	21% ± 8%	Explore
plasmacytoid dendritic cell	19 studies	40% ± 14%	Explore
non-classical monocyte	19 studies	28% ± 14%	Explore
CD8-positive, alpha-beta T cell	19 studies	22% ± 9%	Explore
mast cell	18 studies	24% ± 6%	Explore
regulatory T cell	18 studies	21% ± 5%	Explore
T cell	17 studies	22% ± 6%	Explore
monocyte	17 studies	27% ± 7%	Explore
CD4-positive, alpha-beta T cell	16 studies	23% ± 11%	Explore
smooth muscle cell	15 studies	18% ± 3%	Explore
dendritic cell	13 studies	34% ± 25%	Explore
naive B cell	13 studies	21% ± 6%	Explore
pericyte	13 studies	21% ± 5%	Explore
memory B cell	13 studies	21% ± 5%	Explore
gamma-delta T cell	13 studies	25% ± 15%	Explore
endothelial cell of lymphatic vessel	11 studies	21% ± 6%	Explore
plasma cell	11 studies	29% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	24% ± 6%	Explore
ciliated cell	11 studies	29% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	24% ± 7%	Explore
mature NK T cell	10 studies	21% ± 4%	Explore
epithelial cell	10 studies	35% ± 21%	Explore
basal cell	10 studies	28% ± 14%	Explore
myofibroblast cell	9 studies	21% ± 4%	Explore
myeloid cell	9 studies	26% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	24% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	22% ± 8%	Explore
connective tissue cell	8 studies	23% ± 7%	Explore
endothelial cell of artery	8 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	27% ± 11%	Explore
capillary endothelial cell	7 studies	19% ± 2%	Explore
abnormal cell	7 studies	22% ± 8%	Explore
vein endothelial cell	7 studies	20% ± 5%	Explore
microglial cell	7 studies	22% ± 5%	Explore
mucosal invariant T cell	7 studies	18% ± 2%	Explore
precursor B cell	7 studies	30% ± 9%	Explore
astrocyte	7 studies	29% ± 8%	Explore
endothelial cell of vascular tree	7 studies	20% ± 6%	Explore
type I pneumocyte	6 studies	22% ± 5%	Explore
hematopoietic precursor cell	6 studies	34% ± 16%	Explore
plasmablast	6 studies	45% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	22% ± 5%	Explore
retinal rod cell	6 studies	23% ± 9%	Explore
innate lymphoid cell	6 studies	24% ± 6%	Explore
adipocyte	6 studies	17% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	20% ± 5%	Explore
oligodendrocyte	6 studies	32% ± 11%	Explore
leukocyte	5 studies	26% ± 7%	Explore
mononuclear phagocyte	5 studies	26% ± 12%	Explore
progenitor cell	5 studies	21% ± 4%	Explore
neuron	5 studies	33% ± 14%	Explore
glutamatergic neuron	5 studies	36% ± 19%	Explore
lymphocyte	5 studies	26% ± 8%	Explore
T follicular helper cell	5 studies	19% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 15%	Explore
oligodendrocyte precursor cell	5 studies	25% ± 7%	Explore
goblet cell	5 studies	29% ± 13%	Explore
alveolar macrophage	4 studies	21% ± 6%	Explore
exhausted T cell	4 studies	26% ± 13%	Explore
retinal ganglion cell	4 studies	46% ± 26%	Explore
club cell	4 studies	21% ± 6%	Explore
immature B cell	4 studies	24% ± 6%	Explore
pro-B cell	4 studies	24% ± 1%	Explore
cardiac muscle cell	4 studies	20% ± 4%	Explore
Mueller cell	4 studies	23% ± 6%	Explore
GABAergic neuron	4 studies	33% ± 16%	Explore
hematopoietic stem cell	4 studies	21% ± 3%	Explore
enteroendocrine cell	4 studies	29% ± 13%	Explore
interneuron	4 studies	35% ± 19%	Explore
kidney loop of Henle epithelial cell	3 studies	19% ± 2%	Explore
neural crest cell	3 studies	26% ± 1%	Explore
retinal bipolar neuron	3 studies	30% ± 10%	Explore
amacrine cell	3 studies	40% ± 10%	Explore
retina horizontal cell	3 studies	27% ± 12%	Explore
retinal cone cell	3 studies	38% ± 10%	Explore
tissue-resident macrophage	3 studies	19% ± 1%	Explore
secretory cell	3 studies	28% ± 15%	Explore
germinal center B cell	3 studies	26% ± 2%	Explore
type II pneumocyte	3 studies	24% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 14%	Explore
transit amplifying cell	3 studies	27% ± 13%	Explore
mesothelial cell	3 studies	27% ± 14%	Explore
T-helper 17 cell	3 studies	20% ± 4%	Explore
double negative thymocyte	3 studies	37% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	27% ± 12%	Explore
lung	13 studies	25% ± 9%	Explore
brain	9 studies	29% ± 16%	Explore
eye	8 studies	26% ± 10%	Explore
intestine	7 studies	22% ± 10%	Explore
kidney	5 studies	19% ± 3%	Explore
bone marrow	4 studies	19% ± 2%	Explore
adipose	4 studies	18% ± 3%	Explore
uterus	3 studies	27% ± 16%	Explore
lymph node	3 studies	20% ± 2%	Explore
liver	3 studies	37% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4541.62	2642 / 2642	100%	18.42	705 / 705
esophagus	100%	3146.28	1445 / 1445	100%	13.44	183 / 183
prostate	100%	2859.44	245 / 245	100%	15.02	502 / 502
stomach	100%	2453.14	359 / 359	100%	15.08	286 / 286
lung	100%	3134.85	577 / 578	100%	14.74	1155 / 1155
intestine	100%	3047.36	966 / 966	100%	16.27	526 / 527
bladder	100%	2984.29	21 / 21	100%	16.80	503 / 504
pancreas	100%	1917.06	327 / 328	100%	14.38	178 / 178
thymus	100%	3067.30	653 / 653	100%	17.06	603 / 605
breast	100%	3292.13	459 / 459	100%	18.60	1114 / 1118
uterus	100%	2674.09	170 / 170	100%	17.74	457 / 459
skin	100%	4194.85	1809 / 1809	99%	15.09	469 / 472
liver	100%	1877.26	225 / 226	100%	10.02	404 / 406
kidney	100%	3471.75	89 / 89	99%	13.87	890 / 901
adrenal gland	100%	3211.08	258 / 258	98%	12.52	226 / 230
ovary	100%	3178.73	180 / 180	98%	8.13	422 / 430
adipose	100%	3326.64	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.46	29 / 29
muscle	100%	4642.50	803 / 803	0%	0	0 / 0
spleen	100%	3331.07	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.48	45 / 45
ureter	0%	0	0 / 0	100%	6.72	1 / 1
blood vessel	100%	2845.87	1334 / 1335	0%	0	0 / 0
peripheral blood	98%	2842.84	913 / 929	0%	0	0 / 0
heart	97%	2841.99	835 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	11.88	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0051085	Biological process	chaperone cofactor-dependent protein refolding
GO_1900034	Biological process	regulation of cellular response to heat
GO_0070062	Cellular component	extracellular exosome
GO_0005856	Cellular component	cytoskeleton
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0031072	Molecular function	heat shock protein binding
GO_0005515	Molecular function	protein binding
GO_0001671	Molecular function	ATPase activator activity

IV. Literature review

[source]

Gene name	DNAJC7
Protein name	DnaJ homolog subfamily C member 7 DnaJ heat shock protein family (Hsp40) member C7 DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)
Synonyms	TTC2 TPR2
Description	FUNCTION: Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). .
Accessions	K7EJV7 Q99615 ENST00000674179.1 A0A6I8PLE7 A0A6I8PIK4 K7EPP7 ENST00000674411.1 ENST00000587727.6 K7ELJ8 ENST00000589576.6 ENST00000316603.12 [Q99615-2] ENST00000588814.5 K7ESP1 A0A6I8PUD4 ENST00000589773.5 ENST00000674306.1 ENST00000590774.6 [Q99615-2] K7EIH8 ENST00000590348.6 ENST00000588641.6 A0A6I8PU73 A0A6I8PS32 ENST00000589586.6 A0A6I8PRZ0 A0A6I8PU89 ENST00000586335.2 ENST00000590774 ENST00000426588.7 [Q99615-2] ENST00000674453.1 K7ER44 A0A6I8PUC2 ENST00000457167.9 [Q99615-1] K7EN19 ENST00000585866.6 ENST00000674355.1 ENST00000674214.1 ENST00000674166.1 [Q99615-2] ENST00000674233.1 K7EQ73 ENST00000674252.1 [Q99615-2] K7ENB7 ENST00000674249.1 ENST00000674175.1 K7EJL5 K7EK03 A0A6I8PR93 A0A6I8PR89 ENST00000590886.7 ENST00000589810.5 ENST00000674504.1 ENST00000674303.1 [Q99615-2] ENST00000674472.1 ENST00000674497.1 ENST00000591787.1 ENST00000674287.1 [Q99615-2] K7EJE9

DNAJC7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review