DNAJB14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071218Biological processcellular response to misfolded protein
GO_0051085Biological processchaperone cofactor-dependent protein refolding
GO_0065003Biological processprotein-containing complex assembly
GO_0005783Cellular componentendoplasmic reticulum
GO_0031965Cellular componentnuclear membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005515Molecular functionprotein binding
GO_0030544Molecular functionHsp70 protein binding

IV. Literature review

[source]
Gene nameDNAJB14
Protein nameDnaJ homolog subfamily B member 14
DnaJ heat shock protein family (Hsp40) member B14
SynonymsUNQ9427/PRO34683
DescriptionFUNCTION: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway . Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities . Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers . While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 . When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear . .; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection . .

AccessionsENST00000398991.3
H7BZK3
F2Z2L8
ENST00000420137.5
A0A087WWX2
ENST00000426476.5
ENST00000334223.6
H7C494
Q8TBM8
H7BZG5
ENST00000442697.7 [Q8TBM8-1]
ENST00000610281.1
ENST00000455208.5