CPSF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046833Biological processpositive regulation of RNA export from nucleus
GO_0006397Biological processmRNA processing
GO_0180010Biological processco-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO_0031124Biological processmRNA 3'-end processing
GO_0051262Biological processprotein tetramerization
GO_0110104Biological processmRNA alternative polyadenylation
GO_0051290Biological processprotein heterotetramerization
GO_0005726Cellular componentperichromatin fibrils
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0005847Cellular componentmRNA cleavage and polyadenylation specificity factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005849Cellular componentmRNA cleavage factor complex
GO_0035061Cellular componentinterchromatin granule
GO_1990904Cellular componentribonucleoprotein complex
GO_0042382Cellular componentparaspeckles
GO_0005634Cellular componentnucleus
GO_1990448Molecular functionexon-exon junction complex binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0043023Molecular functionribosomal large subunit binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCPSF6
Protein nameCleavage and polyadenylation specificity factor subunit 6
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Cleavage and polyadenylation specific factor 6
Alternative protein CPSF6
Cleavage and polyadenylation specific factor 6/retinoic acid receptor gamma fusion protein
SynonymsRARG
CFIM68
fusion
DescriptionFUNCTION: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs . CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) . Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation . The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs . CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery . Plays a role in mRNA export . .; FUNCTION: (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro). .

AccessionsENST00000551516.1
ENST00000456847.7
Q16630
A0A3B3ISW1
L8E8D6
ENST00000550075.5
ENST00000435070.7 [Q16630-1]
A0A2P1M905
F8WJN3
ENST00000650046.1
F8VNP8
F8W084
A0A2P1M8Z1
ENST00000266679.8 [Q16630-2]