CENPC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	23 studies	22% ± 7%	Explore
B cell	20 studies	23% ± 8%	Explore
regulatory T cell	17 studies	24% ± 7%	Explore
endothelial cell	16 studies	26% ± 10%	Explore
CD4-positive, alpha-beta T cell	15 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	15 studies	22% ± 5%	Explore
naive B cell	13 studies	23% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	25% ± 6%	Explore
gamma-delta T cell	13 studies	24% ± 8%	Explore
fibroblast	12 studies	25% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	24% ± 8%	Explore
oligodendrocyte	11 studies	28% ± 11%	Explore
T cell	10 studies	23% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	23% ± 7%	Explore
memory B cell	10 studies	20% ± 4%	Explore
mucosal invariant T cell	10 studies	22% ± 4%	Explore
mast cell	9 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	23% ± 7%	Explore
glutamatergic neuron	9 studies	39% ± 25%	Explore
plasmacytoid dendritic cell	9 studies	24% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	27% ± 7%	Explore
mature NK T cell	8 studies	23% ± 4%	Explore
astrocyte	8 studies	30% ± 13%	Explore
microglial cell	7 studies	20% ± 4%	Explore
adipocyte	6 studies	25% ± 7%	Explore
T follicular helper cell	6 studies	22% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	24% ± 5%	Explore
GABAergic neuron	6 studies	42% ± 19%	Explore
macrophage	6 studies	24% ± 8%	Explore
smooth muscle cell	5 studies	19% ± 2%	Explore
epithelial cell	5 studies	36% ± 16%	Explore
amacrine cell	5 studies	24% ± 10%	Explore
oligodendrocyte precursor cell	5 studies	31% ± 10%	Explore
pericyte	5 studies	21% ± 9%	Explore
interneuron	5 studies	41% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	17% ± 1%	Explore
leukocyte	4 studies	23% ± 5%	Explore
non-classical monocyte	4 studies	24% ± 6%	Explore
plasmablast	4 studies	34% ± 12%	Explore
neuron	4 studies	25% ± 12%	Explore
precursor B cell	4 studies	25% ± 7%	Explore
lymphocyte	4 studies	31% ± 10%	Explore
basal cell	4 studies	30% ± 19%	Explore
dendritic cell	4 studies	25% ± 14%	Explore
endothelial cell of lymphatic vessel	4 studies	25% ± 6%	Explore
hematopoietic precursor cell	3 studies	29% ± 11%	Explore
ionocyte	3 studies	37% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
exhausted T cell	3 studies	24% ± 8%	Explore
GABAergic interneuron	3 studies	20% ± 1%	Explore
pro-B cell	3 studies	30% ± 9%	Explore
plasma cell	3 studies	28% ± 6%	Explore
retina horizontal cell	3 studies	22% ± 7%	Explore
retinal bipolar neuron	3 studies	19% ± 4%	Explore
ciliated cell	3 studies	22% ± 3%	Explore
myeloid cell	3 studies	18% ± 3%	Explore
rod bipolar cell	3 studies	22% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	30% ± 8%	Explore
innate lymphoid cell	3 studies	24% ± 3%	Explore
endothelial cell of vascular tree	3 studies	25% ± 11%	Explore
double negative thymocyte	3 studies	30% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	33% ± 19%	Explore
peripheral blood	9 studies	25% ± 6%	Explore
lung	4 studies	19% ± 2%	Explore
eye	3 studies	29% ± 18%	Explore
adipose	3 studies	23% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	1776.27	245 / 245	100%	9.70	500 / 502
esophagus	100%	1436.80	1445 / 1445	99%	8.38	182 / 183
breast	100%	1759.88	459 / 459	99%	10.65	1111 / 1118
thymus	100%	2046.98	653 / 653	99%	11.67	601 / 605
lung	100%	1348.39	577 / 578	99%	7.76	1148 / 1155
pancreas	100%	1506.32	328 / 328	99%	7.50	176 / 178
uterus	100%	1992.55	170 / 170	99%	8.32	453 / 459
brain	98%	848.31	2596 / 2642	100%	6.98	704 / 705
bladder	100%	1468.38	21 / 21	98%	6.68	492 / 504
adrenal gland	100%	1342.92	258 / 258	97%	8.89	222 / 230
intestine	100%	1547.26	966 / 966	96%	5.78	506 / 527
kidney	100%	1049.37	89 / 89	96%	7.08	864 / 901
ovary	100%	2779.31	180 / 180	96%	4.76	411 / 430
stomach	100%	1297.54	359 / 359	95%	5.85	272 / 286
skin	100%	1369.63	1809 / 1809	92%	6.82	432 / 472
liver	98%	622.85	222 / 226	71%	2.90	289 / 406
blood vessel	100%	1425.33	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	7.82	29 / 29
spleen	100%	1763.91	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.92	45 / 45
ureter	0%	0	0 / 0	100%	2.70	1 / 1
adipose	100%	1586.07	1203 / 1204	0%	0	0 / 0
heart	97%	700.43	831 / 861	0%	0	0 / 0
muscle	87%	381.76	697 / 803	0%	0	0 / 0
peripheral blood	70%	826.03	649 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	55%	2.79	44 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000278	Biological process	mitotic cell cycle
GO_0007059	Biological process	chromosome segregation
GO_0051382	Biological process	kinetochore assembly
GO_0051315	Biological process	attachment of mitotic spindle microtubules to kinetochore
GO_0051455	Biological process	spindle attachment to meiosis I kinetochore
GO_0051301	Biological process	cell division
GO_0030496	Cellular component	midbody
GO_0000939	Cellular component	inner kinetochore
GO_0000776	Cellular component	kinetochore
GO_0005654	Cellular component	nucleoplasm
GO_0016604	Cellular component	nuclear body
GO_0005829	Cellular component	cytosol
GO_0005721	Cellular component	pericentric heterochromatin
GO_0000779	Cellular component	condensed chromosome, centromeric region
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0042802	Molecular function	identical protein binding
GO_0019237	Molecular function	centromeric DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CENPC
Protein name	Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7) Centromere protein C
Synonyms	CENPC1 ICEN7
Description	FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. .
Accessions	ENST00000515140.1 H0Y8J2 ENST00000506882.5 [Q03188-2] ENST00000273853.11 [Q03188-1] H0Y9W1 ENST00000513216.5 Q03188

CENPC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review