CDKN1B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	25 studies	29% ± 10%	Explore
B cell	23 studies	23% ± 7%	Explore
regulatory T cell	22 studies	39% ± 12%	Explore
CD8-positive, alpha-beta T cell	22 studies	26% ± 8%	Explore
T cell	20 studies	28% ± 10%	Explore
natural killer cell	20 studies	24% ± 7%	Explore
naive B cell	17 studies	23% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	29% ± 11%	Explore
memory B cell	15 studies	22% ± 6%	Explore
gamma-delta T cell	15 studies	28% ± 9%	Explore
mature NK T cell	13 studies	27% ± 12%	Explore
mucosal invariant T cell	13 studies	33% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	29% ± 9%	Explore
pericyte	12 studies	21% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	33% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 6%	Explore
endothelial cell	9 studies	26% ± 8%	Explore
non-classical monocyte	9 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	25% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	30% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	34% ± 13%	Explore
macrophage	8 studies	20% ± 5%	Explore
T follicular helper cell	7 studies	27% ± 11%	Explore
smooth muscle cell	6 studies	18% ± 2%	Explore
plasma cell	6 studies	28% ± 9%	Explore
classical monocyte	6 studies	22% ± 9%	Explore
fibroblast	6 studies	23% ± 5%	Explore
dendritic cell	5 studies	30% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
leukocyte	5 studies	26% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	39% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	30% ± 6%	Explore
conventional dendritic cell	4 studies	32% ± 17%	Explore
capillary endothelial cell	4 studies	20% ± 4%	Explore
epithelial cell	4 studies	34% ± 8%	Explore
oligodendrocyte	4 studies	21% ± 5%	Explore
endothelial cell of vascular tree	4 studies	20% ± 2%	Explore
innate lymphoid cell	4 studies	23% ± 5%	Explore
glutamatergic neuron	4 studies	22% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 6%	Explore
monocyte	3 studies	20% ± 5%	Explore
endothelial cell of lymphatic vessel	3 studies	22% ± 2%	Explore
exhausted T cell	3 studies	29% ± 6%	Explore
plasmablast	3 studies	35% ± 9%	Explore
immature B cell	3 studies	25% ± 4%	Explore
pro-B cell	3 studies	30% ± 6%	Explore
Mueller cell	3 studies	47% ± 9%	Explore
CD4-positive helper T cell	3 studies	36% ± 11%	Explore
GABAergic neuron	3 studies	22% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 5%	Explore
T-helper 17 cell	3 studies	22% ± 4%	Explore
erythrocyte	3 studies	26% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	39% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	34% ± 11%	Explore
double negative thymocyte	3 studies	32% ± 5%	Explore
interneuron	3 studies	25% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	26% ± 7%	Explore
lung	6 studies	19% ± 4%	Explore
brain	5 studies	20% ± 4%	Explore
bone marrow	3 studies	21% ± 4%	Explore
eye	3 studies	25% ± 3%	Explore
liver	3 studies	31% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	5722.78	2641 / 2642	100%	165.75	705 / 705
lung	100%	5006.48	577 / 578	100%	84.13	1153 / 1155
intestine	100%	5068.73	966 / 966	99%	94.63	523 / 527
prostate	100%	3794.68	244 / 245	100%	90.50	500 / 502
thymus	100%	4645.05	652 / 653	99%	106.53	601 / 605
adrenal gland	100%	4181.63	258 / 258	99%	117.11	227 / 230
breast	100%	6726.60	459 / 459	99%	145.46	1103 / 1118
bladder	100%	4067.86	21 / 21	98%	87.53	496 / 504
uterus	100%	6534.80	170 / 170	98%	96.92	449 / 459
esophagus	100%	3963.46	1444 / 1445	98%	50.94	179 / 183
stomach	99%	2865.16	356 / 359	98%	86.15	281 / 286
ovary	100%	5911.44	180 / 180	97%	66.95	418 / 430
liver	100%	2304.09	225 / 226	95%	49.02	386 / 406
skin	99%	4397.95	1797 / 1809	95%	62.76	448 / 472
kidney	98%	2710.72	87 / 89	95%	75.65	857 / 901
pancreas	93%	1616.86	304 / 328	98%	69.20	175 / 178
blood vessel	100%	7268.57	1335 / 1335	0%	0	0 / 0
spleen	100%	5474.58	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	29.39	1 / 1
adipose	100%	6280.20	1200 / 1204	0%	0	0 / 0
muscle	99%	3947.95	797 / 803	0%	0	0 / 0
peripheral blood	98%	5355.57	915 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	100.22	44 / 45
lymph node	0%	0	0 / 0	97%	65.87	28 / 29
heart	95%	2396.59	818 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	84%	51.09	67 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032355	Biological process	response to estradiol
GO_0007605	Biological process	sensory perception of sound
GO_0006813	Biological process	potassium ion transport
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0071236	Biological process	cellular response to antibiotic
GO_0043200	Biological process	response to amino acid
GO_1902746	Biological process	regulation of lens fiber cell differentiation
GO_0043434	Biological process	response to peptide hormone
GO_0007219	Biological process	Notch signaling pathway
GO_0009749	Biological process	response to glucose
GO_1904706	Biological process	negative regulation of vascular associated smooth muscle cell proliferation
GO_0007507	Biological process	heart development
GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0071456	Biological process	cellular response to hypoxia
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_1902806	Biological process	regulation of cell cycle G1/S phase transition
GO_0007096	Biological process	regulation of exit from mitosis
GO_0048839	Biological process	inner ear development
GO_0051168	Biological process	nuclear export
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0031116	Biological process	positive regulation of microtubule polymerization
GO_0001890	Biological process	placenta development
GO_0042326	Biological process	negative regulation of phosphorylation
GO_1905179	Biological process	negative regulation of cardiac muscle tissue regeneration
GO_0046686	Biological process	response to cadmium ion
GO_0048102	Biological process	autophagic cell death
GO_0060770	Biological process	negative regulation of epithelial cell proliferation involved in prostate gland development
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_0033673	Biological process	negative regulation of kinase activity
GO_0045740	Biological process	positive regulation of DNA replication
GO_0030334	Biological process	regulation of cell migration
GO_1904036	Biological process	negative regulation of epithelial cell apoptotic process
GO_1904030	Biological process	negative regulation of cyclin-dependent protein kinase activity
GO_0060767	Biological process	epithelial cell proliferation involved in prostate gland development
GO_0006977	Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_1904019	Biological process	epithelial cell apoptotic process
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0090398	Biological process	cellular senescence
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0045930	Biological process	negative regulation of mitotic cell cycle
GO_0045736	Biological process	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0071407	Biological process	cellular response to organic cyclic compound
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0051726	Biological process	regulation of cell cycle
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0071285	Biological process	cellular response to lithium ion
GO_0030308	Biological process	negative regulation of cell growth
GO_0031464	Cellular component	Cul4A-RING E3 ubiquitin ligase complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005768	Cellular component	endosome
GO_0005634	Cellular component	nucleus
GO_0004860	Molecular function	protein kinase inhibitor activity
GO_0060090	Molecular function	molecular adaptor activity
GO_0019903	Molecular function	protein phosphatase binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0019901	Molecular function	protein kinase binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0030544	Molecular function	Hsp70 protein binding
GO_0030332	Molecular function	cyclin binding
GO_1990757	Molecular function	ubiquitin ligase activator activity
GO_0019914	Molecular function	cyclin-dependent protein kinase activating kinase regulator activity
GO_0004861	Molecular function	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO_0005515	Molecular function	protein binding
GO_0140678	Molecular function	molecular function inhibitor activity

IV. Literature review

[source]

Gene name	CDKN1B
Protein name	Truncated cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1)
Synonyms	hCG_27692 p27 KIP1
Description	FUNCTION: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. .
Accessions	ENST00000396340.1 ENST00000614874.2 A7KMP4 ENST00000228872.9 P46527 H7C2T1 Q6I9V6 Q708J1 E7ES52 ENST00000442489.1

CDKN1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review