CD55 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	36 studies	42% ± 14%	Explore
endothelial cell	30 studies	30% ± 15%	Explore
natural killer cell	28 studies	26% ± 6%	Explore
macrophage	27 studies	30% ± 13%	Explore
classical monocyte	26 studies	53% ± 14%	Explore
conventional dendritic cell	26 studies	35% ± 14%	Explore
monocyte	25 studies	41% ± 16%	Explore
non-classical monocyte	24 studies	56% ± 12%	Explore
CD4-positive, alpha-beta T cell	24 studies	29% ± 10%	Explore
mast cell	22 studies	27% ± 7%	Explore
T cell	20 studies	28% ± 11%	Explore
naive B cell	20 studies	44% ± 14%	Explore
memory B cell	19 studies	39% ± 16%	Explore
epithelial cell	19 studies	44% ± 20%	Explore
CD8-positive, alpha-beta T cell	19 studies	26% ± 11%	Explore
plasmacytoid dendritic cell	18 studies	34% ± 10%	Explore
basal cell	18 studies	32% ± 14%	Explore
ciliated cell	18 studies	32% ± 17%	Explore
fibroblast	18 studies	28% ± 11%	Explore
dendritic cell	17 studies	42% ± 13%	Explore
endothelial cell of lymphatic vessel	17 studies	31% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	31% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	28% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	33% ± 12%	Explore
neutrophil	13 studies	58% ± 12%	Explore
type I pneumocyte	12 studies	83% ± 11%	Explore
type II pneumocyte	12 studies	45% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	27% ± 9%	Explore
gamma-delta T cell	12 studies	29% ± 12%	Explore
mature NK T cell	11 studies	24% ± 10%	Explore
mucosal invariant T cell	11 studies	26% ± 7%	Explore
endothelial cell of vascular tree	11 studies	38% ± 17%	Explore
myeloid cell	11 studies	31% ± 17%	Explore
plasma cell	10 studies	31% ± 11%	Explore
club cell	10 studies	51% ± 14%	Explore
secretory cell	10 studies	49% ± 11%	Explore
endothelial cell of artery	10 studies	23% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	28% ± 9%	Explore
regulatory T cell	9 studies	22% ± 6%	Explore
vein endothelial cell	9 studies	28% ± 13%	Explore
respiratory goblet cell	8 studies	68% ± 13%	Explore
connective tissue cell	8 studies	37% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	24% ± 8%	Explore
oligodendrocyte	8 studies	32% ± 9%	Explore
alveolar macrophage	7 studies	31% ± 7%	Explore
plasmablast	7 studies	36% ± 15%	Explore
smooth muscle cell	7 studies	25% ± 7%	Explore
goblet cell	7 studies	34% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	28% ± 9%	Explore
precursor B cell	6 studies	38% ± 13%	Explore
innate lymphoid cell	6 studies	33% ± 6%	Explore
leukocyte	6 studies	33% ± 12%	Explore
platelet	5 studies	19% ± 3%	Explore
mononuclear phagocyte	5 studies	38% ± 16%	Explore
myofibroblast cell	5 studies	31% ± 15%	Explore
immature B cell	5 studies	53% ± 11%	Explore
mesothelial cell	5 studies	22% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	23% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	31% ± 11%	Explore
deuterosomal cell	4 studies	29% ± 7%	Explore
squamous epithelial cell	4 studies	48% ± 23%	Explore
monocyte-derived dendritic cell	4 studies	43% ± 13%	Explore
progenitor cell	4 studies	26% ± 7%	Explore
adventitial cell	4 studies	28% ± 11%	Explore
intermediate monocyte	4 studies	70% ± 15%	Explore
pericyte	4 studies	19% ± 2%	Explore
granulocyte	4 studies	40% ± 9%	Explore
mucus secreting cell	4 studies	44% ± 28%	Explore
abnormal cell	4 studies	28% ± 9%	Explore
CD4-positive helper T cell	3 studies	28% ± 9%	Explore
hematopoietic precursor cell	3 studies	40% ± 14%	Explore
duct epithelial cell	3 studies	56% ± 14%	Explore
pancreatic A cell	3 studies	34% ± 12%	Explore
extravillous trophoblast	3 studies	75% ± 5%	Explore
placental villous trophoblast	3 studies	67% ± 16%	Explore
enterocyte	3 studies	22% ± 5%	Explore
serous secreting cell	3 studies	26% ± 12%	Explore
lymphocyte	3 studies	37% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
IgA plasma cell	3 studies	30% ± 19%	Explore
GABAergic neuron	3 studies	29% ± 8%	Explore
glutamatergic neuron	3 studies	28% ± 12%	Explore
T follicular helper cell	3 studies	26% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 11%	Explore
double negative thymocyte	3 studies	24% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 6%	Explore
erythrocyte	3 studies	33% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	33% ± 11%	Explore
peripheral blood	17 studies	32% ± 9%	Explore
intestine	6 studies	22% ± 5%	Explore
uterus	6 studies	35% ± 13%	Explore
brain	5 studies	27% ± 7%	Explore
liver	5 studies	24% ± 4%	Explore
placenta	4 studies	42% ± 22%	Explore
bone marrow	4 studies	23% ± 5%	Explore
breast	4 studies	24% ± 5%	Explore
kidney	3 studies	20% ± 3%	Explore
ovary	3 studies	26% ± 8%	Explore
esophagus	3 studies	30% ± 7%	Explore
lymph node	3 studies	29% ± 7%	Explore
prostate	3 studies	38% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	19312.14	578 / 578	97%	162.14	1123 / 1155
ovary	100%	7522.41	180 / 180	97%	73.62	415 / 430
intestine	96%	3197.15	925 / 966	96%	121.11	507 / 527
esophagus	96%	4028.01	1380 / 1445	96%	140.91	176 / 183
breast	100%	4089.97	457 / 459	92%	58.43	1029 / 1118
skin	100%	8107.99	1809 / 1809	86%	75.72	404 / 472
adrenal gland	100%	13965.53	258 / 258	85%	43.53	196 / 230
bladder	95%	4078.29	20 / 21	88%	76.34	443 / 504
uterus	97%	2838.01	165 / 170	85%	112.05	391 / 459
thymus	91%	2307.08	597 / 653	83%	181.89	501 / 605
stomach	58%	3624.90	210 / 359	94%	117.34	269 / 286
pancreas	19%	438.54	62 / 328	97%	156.63	173 / 178
kidney	67%	1852.64	60 / 89	40%	13.36	363 / 901
spleen	100%	5472.50	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	35.34	1 / 1
adipose	100%	5828.43	1199 / 1204	0%	0	0 / 0
peripheral blood	99%	24886.31	924 / 929	0%	0	0 / 0
muscle	99%	6854.74	796 / 803	0%	0	0 / 0
blood vessel	97%	4782.87	1292 / 1335	0%	0	0 / 0
heart	92%	3392.23	788 / 861	0%	0	0 / 0
prostate	58%	1326.67	142 / 245	28%	8.10	140 / 502
tonsil	0%	0	0 / 0	73%	33.79	33 / 45
eye	0%	0	0 / 0	60%	21.10	48 / 80
liver	30%	703.61	67 / 226	20%	8.04	83 / 406
brain	29%	623.43	754 / 2642	2%	0.60	14 / 705
lymph node	0%	0	0 / 0	24%	6.17	7 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045730	Biological process	respiratory burst
GO_0002726	Biological process	positive regulation of T cell cytokine production
GO_0030449	Biological process	regulation of complement activation
GO_0045087	Biological process	innate immune response
GO_2000516	Biological process	positive regulation of CD4-positive, alpha-beta T cell activation
GO_0045916	Biological process	negative regulation of complement activation
GO_0046718	Biological process	symbiont entry into host cell
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0006958	Biological process	complement activation, classical pathway
GO_1903659	Biological process	regulation of complement-dependent cytotoxicity
GO_2000563	Biological process	positive regulation of CD4-positive, alpha-beta T cell proliferation
GO_0031664	Biological process	regulation of lipopolysaccharide-mediated signaling pathway
GO_0030667	Cellular component	secretory granule membrane
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0070062	Cellular component	extracellular exosome
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986	Cellular component	cell surface
GO_0000139	Cellular component	Golgi membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0030133	Cellular component	transport vesicle
GO_0098552	Cellular component	side of membrane
GO_0008289	Molecular function	lipid binding
GO_0001618	Molecular function	virus receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD55
Protein name	Complement decay-accelerating factor Complement decay-accelerating factor (CD antigen CD55) CD55 antigen, decay accelerating factor for complement (Cromer blood group), isoform CRA_d (CD55 molecule (Cromer blood group)) Rh blood group D antigen CD55 molecule (Cromer Blood Group) Cromer blood group antigen CD55 molecule (Cromer blood group)
Synonyms	DAF hCG_22206 CROM CR
Description	FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade . Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage . .; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. .; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). .; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. .
Accessions	B1AP15 A0A8Q3SI51 A0A8Q3WLV2 ENST00000635614.2 A0A2R8YEC5 A0A2R8YDY3 A0A2H4ZEU7 ENST00000367064.9 [P08174-1] ENST00000367063.6 ENST00000695828.1 B1AP13 P08174 ENST00000314754.12 [P08174-2] A0A7G9ZDP2 ENST00000695826.1 ENST00000695823.1 A0A2R8Y4B4 H3BLV0 A0A8Q3SI94 A0A8Q3WKT6 ENST00000343420.6 ENST00000695824.1 A0A223PIC2 ENST00000644836.1 [P08174-3] ENST00000695825.1 A0A172WBW8 ENST00000645323.1 [P08174-5] ENST00000634386.1 ENST00000391921.9 ENST00000618707.2

CD55 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review