CCNH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0050821Biological processprotein stabilization
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070516Cellular componentCAK-ERCC2 complex
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0070985Cellular componenttranscription factor TFIIK complex
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0005634Cellular componentnucleus
GO_0016251Molecular functionRNA polymerase II general transcription initiation factor activity
GO_0016538Molecular functioncyclin-dependent protein serine/threonine kinase regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCNH
Protein nameCyclin H
Cyclin-H (MO15-associated protein) (p34) (p37)
Cyclin-H
Synonyms
DescriptionFUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. .

FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. .

FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. .

FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. .

AccessionsENST00000508855.5
A0A2R8Y4K6
ENST00000504878.1
ENST00000256897.9
D6RG18
ENST00000646883.1
P51946
D6RHI7
ENST00000645953.1
A0A2R8YEM2