Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| peripheral blood | 14 studies | 27% ± 6% | |
| lung | 10 studies | 23% ± 6% | |
| intestine | 8 studies | 21% ± 8% | |
| liver | 5 studies | 28% ± 19% | |
| brain | 5 studies | 20% ± 3% | |
| lymph node | 4 studies | 27% ± 4% | |
| pancreas | 3 studies | 28% ± 11% | |
| kidney | 3 studies | 27% ± 6% | |
| bone marrow | 3 studies | 23% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3915.00 | 1445 / 1445 | 100% | 45.97 | 183 / 183 |
| lung | 100% | 3632.25 | 578 / 578 | 100% | 39.30 | 1155 / 1155 |
| ovary | 100% | 4022.83 | 180 / 180 | 100% | 34.73 | 430 / 430 |
| stomach | 100% | 3061.50 | 359 / 359 | 100% | 46.10 | 286 / 286 |
| uterus | 100% | 4012.72 | 170 / 170 | 100% | 53.23 | 459 / 459 |
| breast | 100% | 4337.49 | 459 / 459 | 100% | 70.54 | 1117 / 1118 |
| intestine | 100% | 4314.37 | 966 / 966 | 100% | 48.20 | 526 / 527 |
| bladder | 100% | 3770.14 | 21 / 21 | 100% | 44.75 | 503 / 504 |
| prostate | 100% | 3590.29 | 245 / 245 | 100% | 30.74 | 501 / 502 |
| thymus | 100% | 4031.52 | 653 / 653 | 100% | 30.33 | 603 / 605 |
| brain | 100% | 2867.10 | 2630 / 2642 | 100% | 31.60 | 705 / 705 |
| skin | 100% | 5844.50 | 1809 / 1809 | 99% | 31.59 | 467 / 472 |
| pancreas | 100% | 1855.65 | 327 / 328 | 99% | 31.10 | 176 / 178 |
| liver | 100% | 2205.52 | 226 / 226 | 99% | 21.71 | 400 / 406 |
| adrenal gland | 100% | 5018.67 | 258 / 258 | 98% | 45.35 | 226 / 230 |
| kidney | 100% | 2975.53 | 89 / 89 | 96% | 23.21 | 867 / 901 |
| adipose | 100% | 3877.52 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3683.97 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 67.24 | 29 / 29 |
| spleen | 100% | 6096.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 50.15 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 26.51 | 1 / 1 |
| muscle | 99% | 2151.54 | 798 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1845.92 | 846 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 4285.32 | 878 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 16.09 | 74 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034501 | Biological process | protein localization to kinetochore |
| GO_0051321 | Biological process | meiotic cell cycle |
| GO_0008608 | Biological process | attachment of spindle microtubules to kinetochore |
| GO_0051301 | Biological process | cell division |
| GO_0007094 | Biological process | mitotic spindle assembly checkpoint signaling |
| GO_0000776 | Cellular component | kinetochore |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0033597 | Cellular component | mitotic checkpoint complex |
| GO_1990298 | Cellular component | bub1-bub3 complex |
| GO_0005515 | Molecular function | protein binding |
| GO_0043130 | Molecular function | ubiquitin binding |
| Gene name | BUB3 |
| Protein name | Mitotic checkpoint protein BUB3 |
| Synonyms | |
| Description | FUNCTION: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. . |
| Accessions | ENST00000368865.9 [O43684-1] ENST00000407911.2 O43684 ENST00000368859.6 J3QT28 ENST00000368858.9 [O43684-2] J3QSX4 |