BUB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034501Biological processprotein localization to kinetochore
GO_0051321Biological processmeiotic cell cycle
GO_0008608Biological processattachment of spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0033597Cellular componentmitotic checkpoint complex
GO_1990298Cellular componentbub1-bub3 complex
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameBUB3
Protein nameMitotic checkpoint protein BUB3
Synonyms
DescriptionFUNCTION: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. .

AccessionsENST00000368865.9 [O43684-1]
ENST00000407911.2
O43684
ENST00000368859.6
J3QT28
ENST00000368858.9 [O43684-2]
J3QSX4