ARIH2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	22 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	18 studies	22% ± 5%	Explore
endothelial cell	16 studies	26% ± 8%	Explore
regulatory T cell	16 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	30% ± 8%	Explore
CD4-positive, alpha-beta T cell	13 studies	20% ± 3%	Explore
oligodendrocyte	13 studies	32% ± 12%	Explore
B cell	12 studies	20% ± 2%	Explore
T cell	12 studies	20% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	24% ± 6%	Explore
gamma-delta T cell	11 studies	27% ± 8%	Explore
naive B cell	10 studies	20% ± 4%	Explore
microglial cell	10 studies	24% ± 8%	Explore
fibroblast	10 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 8%	Explore
astrocyte	10 studies	29% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	20% ± 3%	Explore
mucosal invariant T cell	9 studies	26% ± 6%	Explore
plasmacytoid dendritic cell	9 studies	24% ± 6%	Explore
adipocyte	9 studies	26% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
mature NK T cell	8 studies	25% ± 3%	Explore
memory B cell	8 studies	20% ± 3%	Explore
macrophage	8 studies	24% ± 8%	Explore
oligodendrocyte precursor cell	8 studies	25% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 5%	Explore
glutamatergic neuron	7 studies	39% ± 24%	Explore
epithelial cell	7 studies	33% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
ciliated cell	6 studies	23% ± 6%	Explore
GABAergic neuron	6 studies	41% ± 20%	Explore
smooth muscle cell	6 studies	20% ± 3%	Explore
classical monocyte	5 studies	22% ± 4%	Explore
non-classical monocyte	5 studies	23% ± 7%	Explore
lymphocyte	5 studies	25% ± 4%	Explore
myeloid cell	5 studies	22% ± 4%	Explore
retinal rod cell	5 studies	23% ± 3%	Explore
cardiac muscle cell	5 studies	36% ± 8%	Explore
T follicular helper cell	5 studies	20% ± 3%	Explore
type I pneumocyte	5 studies	19% ± 4%	Explore
dendritic cell	5 studies	28% ± 12%	Explore
plasma cell	4 studies	26% ± 10%	Explore
leukocyte	4 studies	21% ± 3%	Explore
exhausted T cell	4 studies	23% ± 3%	Explore
neuron	4 studies	33% ± 13%	Explore
precursor B cell	4 studies	24% ± 5%	Explore
retina horizontal cell	4 studies	22% ± 5%	Explore
retinal cone cell	4 studies	30% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
pericyte	4 studies	24% ± 8%	Explore
type II pneumocyte	4 studies	20% ± 4%	Explore
abnormal cell	4 studies	26% ± 8%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 4%	Explore
monocyte	4 studies	20% ± 2%	Explore
basal cell	4 studies	27% ± 11%	Explore
interneuron	4 studies	43% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 5%	Explore
conventional dendritic cell	3 studies	34% ± 12%	Explore
plasmablast	3 studies	37% ± 16%	Explore
GABAergic interneuron	3 studies	17% ± 3%	Explore
immature B cell	3 studies	20% ± 1%	Explore
Mueller cell	3 studies	17% ± 2%	Explore
rod bipolar cell	3 studies	16% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 2%	Explore
myofibroblast cell	3 studies	22% ± 3%	Explore
innate lymphoid cell	3 studies	24% ± 5%	Explore
muscle cell	3 studies	28% ± 12%	Explore
club cell	3 studies	22% ± 5%	Explore
alveolar macrophage	3 studies	23% ± 6%	Explore
goblet cell	3 studies	31% ± 15%	Explore
transit amplifying cell	3 studies	32% ± 18%	Explore
double negative thymocyte	3 studies	33% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	29% ± 18%	Explore
peripheral blood	12 studies	23% ± 3%	Explore
eye	6 studies	24% ± 7%	Explore
heart	4 studies	24% ± 6%	Explore
adipose	4 studies	19% ± 1%	Explore
lung	3 studies	24% ± 2%	Explore
intestine	3 studies	18% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4544.90	21 / 21	100%	21.86	504 / 504
breast	100%	4561.61	459 / 459	100%	24.67	1118 / 1118
esophagus	100%	4540.22	1445 / 1445	100%	18.98	183 / 183
lung	100%	4301.50	578 / 578	100%	20.11	1155 / 1155
ovary	100%	3943.52	180 / 180	100%	20.31	430 / 430
stomach	100%	3996.26	359 / 359	100%	21.40	286 / 286
intestine	100%	5115.48	966 / 966	100%	22.49	526 / 527
prostate	100%	5034.39	245 / 245	100%	22.98	501 / 502
skin	100%	3839.17	1809 / 1809	100%	29.55	471 / 472
uterus	100%	4686.44	170 / 170	99%	21.36	456 / 459
thymus	100%	5090.85	653 / 653	99%	24.47	601 / 605
brain	99%	3385.36	2622 / 2642	100%	30.00	705 / 705
pancreas	100%	3342.14	328 / 328	99%	19.45	176 / 178
kidney	100%	3537.66	89 / 89	99%	16.10	888 / 901
adrenal gland	100%	4607.52	258 / 258	98%	17.41	226 / 230
liver	100%	2321.60	226 / 226	95%	13.12	385 / 406
adipose	100%	4360.67	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3969.21	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	26.04	29 / 29
muscle	100%	9194.63	803 / 803	0%	0	0 / 0
spleen	100%	5191.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.23	45 / 45
ureter	0%	0	0 / 0	100%	12.95	1 / 1
heart	98%	5584.30	846 / 861	0%	0	0 / 0
peripheral blood	95%	2375.27	878 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	13.67	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0048588	Biological process	developmental cell growth
GO_1903955	Biological process	positive regulation of protein targeting to mitochondrion
GO_0000209	Biological process	protein polyubiquitination
GO_0071425	Biological process	hematopoietic stem cell proliferation
GO_0070534	Biological process	protein K63-linked ubiquitination
GO_0031466	Cellular component	Cul5-RING ubiquitin ligase complex
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0031624	Molecular function	ubiquitin conjugating enzyme binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	ARIH2
Protein name	Ariadne RBR E3 ubiquitin protein ligase 2 E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein) RBR-type E3 ubiquitin transferase (EC 2.3.2.31)
Synonyms	hCG_1779445 HT005 TRIAD1 ARI2
Description	FUNCTION: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 . Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex . Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination . May play a role in myelopoiesis . .
Accessions	ENST00000452882.5 ENST00000356401.9 F8WCS4 C9JAU2 O95376 ENST00000420814.5 Q6IBL8 C9JBC5 ENST00000449376.5 C9JZ71 ENST00000449729.5 ENST00000452385.5 ENST00000430423.5 C9JCL4 ENST00000433170.5

ARIH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review