AP3S1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036465Biological processsynaptic vesicle recycling
GO_0046907Biological processintracellular transport
GO_0035654Biological processclathrin-coated vesicle cargo loading, AP-3-mediated
GO_0008089Biological processanterograde axonal transport
GO_0006886Biological processintracellular protein transport
GO_0048490Biological processanterograde synaptic vesicle transport
GO_0016192Biological processvesicle-mediated transport
GO_0008286Biological processinsulin receptor signaling pathway
GO_0060155Biological processplatelet dense granule organization
GO_0006896Biological processGolgi to vacuole transport
GO_1903232Biological processmelanosome assembly
GO_0016183Biological processsynaptic vesicle coating
GO_0098793Cellular componentpresynapse
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_0030123Cellular componentAP-3 adaptor complex
GO_0030133Cellular componenttransport vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030119Cellular componentAP-type membrane coat adaptor complex
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_1904115Cellular componentaxon cytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP3S1
Protein nameAP complex subunit sigma
AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)
SynonymsCLAPS3
DescriptionFUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. .

AccessionsQ92572
F5H459
ENST00000316788.12
ENST00000506430.2