AMD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	26 studies	26% ± 7%	Explore
natural killer cell	26 studies	25% ± 8%	Explore
CD4-positive, alpha-beta T cell	26 studies	24% ± 8%	Explore
macrophage	23 studies	27% ± 8%	Explore
endothelial cell	23 studies	30% ± 10%	Explore
CD8-positive, alpha-beta T cell	22 studies	23% ± 7%	Explore
T cell	19 studies	28% ± 12%	Explore
fibroblast	19 studies	32% ± 13%	Explore
regulatory T cell	18 studies	25% ± 8%	Explore
oligodendrocyte	17 studies	35% ± 15%	Explore
smooth muscle cell	16 studies	29% ± 10%	Explore
conventional dendritic cell	16 studies	28% ± 12%	Explore
basal cell	15 studies	32% ± 13%	Explore
memory B cell	14 studies	23% ± 7%	Explore
mast cell	13 studies	26% ± 8%	Explore
naive B cell	13 studies	24% ± 6%	Explore
epithelial cell	13 studies	34% ± 21%	Explore
pericyte	13 studies	33% ± 12%	Explore
classical monocyte	11 studies	24% ± 10%	Explore
gamma-delta T cell	11 studies	28% ± 13%	Explore
monocyte	10 studies	24% ± 7%	Explore
non-classical monocyte	10 studies	28% ± 13%	Explore
mature NK T cell	10 studies	26% ± 9%	Explore
endothelial cell of vascular tree	10 studies	31% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	24% ± 7%	Explore
connective tissue cell	9 studies	29% ± 8%	Explore
microglial cell	9 studies	26% ± 9%	Explore
mucosal invariant T cell	9 studies	22% ± 6%	Explore
myeloid cell	9 studies	26% ± 12%	Explore
dendritic cell	8 studies	37% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 7%	Explore
endothelial cell of artery	8 studies	28% ± 14%	Explore
secretory cell	8 studies	24% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	30% ± 10%	Explore
type II pneumocyte	7 studies	33% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	29% ± 14%	Explore
leukocyte	7 studies	30% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	23% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	28% ± 9%	Explore
abnormal cell	7 studies	23% ± 7%	Explore
astrocyte	7 studies	30% ± 13%	Explore
hematopoietic stem cell	7 studies	44% ± 6%	Explore
oligodendrocyte precursor cell	7 studies	27% ± 8%	Explore
endothelial cell of lymphatic vessel	6 studies	36% ± 11%	Explore
platelet	6 studies	28% ± 11%	Explore
mononuclear phagocyte	6 studies	27% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	22% ± 4%	Explore
progenitor cell	6 studies	23% ± 11%	Explore
glutamatergic neuron	6 studies	41% ± 22%	Explore
plasmacytoid dendritic cell	6 studies	22% ± 9%	Explore
hematopoietic precursor cell	5 studies	38% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	31% ± 9%	Explore
myofibroblast cell	5 studies	30% ± 12%	Explore
precursor B cell	5 studies	27% ± 6%	Explore
pro-B cell	5 studies	26% ± 5%	Explore
innate lymphoid cell	5 studies	26% ± 8%	Explore
alveolar macrophage	5 studies	18% ± 4%	Explore
Mueller cell	5 studies	42% ± 20%	Explore
T follicular helper cell	5 studies	30% ± 9%	Explore
GABAergic neuron	5 studies	37% ± 16%	Explore
type I pneumocyte	4 studies	33% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	29% ± 8%	Explore
neuron	4 studies	35% ± 15%	Explore
retinal ganglion cell	4 studies	47% ± 28%	Explore
erythroblast	4 studies	44% ± 21%	Explore
lymphocyte	4 studies	34% ± 12%	Explore
megakaryocyte	4 studies	31% ± 9%	Explore
club cell	4 studies	26% ± 12%	Explore
immature B cell	4 studies	28% ± 13%	Explore
amacrine cell	4 studies	31% ± 13%	Explore
retinal rod cell	4 studies	26% ± 7%	Explore
ciliated cell	4 studies	34% ± 22%	Explore
CD4-positive helper T cell	4 studies	30% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 9%	Explore
granulocyte	4 studies	26% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	51% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	49% ± 32%	Explore
transit amplifying cell	4 studies	25% ± 11%	Explore
T-helper 17 cell	4 studies	28% ± 9%	Explore
squamous epithelial cell	3 studies	33% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	29% ± 8%	Explore
plasmablast	3 studies	37% ± 17%	Explore
capillary endothelial cell	3 studies	25% ± 12%	Explore
renal alpha-intercalated cell	3 studies	28% ± 3%	Explore
retinal bipolar neuron	3 studies	35% ± 9%	Explore
extravillous trophoblast	3 studies	29% ± 8%	Explore
plasma cell	3 studies	30% ± 12%	Explore
retina horizontal cell	3 studies	28% ± 8%	Explore
retinal cone cell	3 studies	31% ± 8%	Explore
retinal pigment epithelial cell	3 studies	29% ± 12%	Explore
tissue-resident macrophage	3 studies	25% ± 9%	Explore
mesothelial cell	3 studies	37% ± 11%	Explore
germinal center B cell	3 studies	28% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	37% ± 13%	Explore
vein endothelial cell	3 studies	33% ± 14%	Explore
muscle cell	3 studies	25% ± 5%	Explore
brush cell	3 studies	22% ± 1%	Explore
enteroendocrine cell	3 studies	24% ± 7%	Explore
goblet cell	3 studies	26% ± 2%	Explore
intestinal crypt stem cell	3 studies	22% ± 4%	Explore
interneuron	3 studies	40% ± 17%	Explore
progenitor cell of mammary luminal epithelium	3 studies	35% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	31% ± 18%	Explore
lung	12 studies	24% ± 8%	Explore
peripheral blood	10 studies	26% ± 11%	Explore
eye	8 studies	34% ± 10%	Explore
intestine	6 studies	25% ± 9%	Explore
kidney	6 studies	19% ± 3%	Explore
uterus	5 studies	35% ± 11%	Explore
prostate	5 studies	32% ± 5%	Explore
bone marrow	4 studies	20% ± 5%	Explore
breast	4 studies	37% ± 9%	Explore
liver	4 studies	38% ± 18%	Explore
placenta	3 studies	25% ± 7%	Explore
thymus	3 studies	33% ± 11%	Explore
lymph node	3 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5041.39	1445 / 1445	100%	41.50	183 / 183
ovary	100%	4149.45	180 / 180	100%	25.42	430 / 430
prostate	100%	22346.94	245 / 245	100%	181.01	502 / 502
uterus	100%	3956.15	170 / 170	100%	33.41	459 / 459
brain	100%	5585.04	2640 / 2642	100%	37.24	705 / 705
lung	100%	4892.75	577 / 578	100%	33.86	1154 / 1155
stomach	100%	4195.30	359 / 359	100%	35.95	285 / 286
thymus	100%	4995.06	653 / 653	99%	26.29	599 / 605
pancreas	100%	2612.76	328 / 328	99%	21.02	176 / 178
intestine	100%	4311.89	966 / 966	99%	36.76	521 / 527
breast	100%	3693.12	459 / 459	99%	32.24	1104 / 1118
bladder	100%	3704.52	21 / 21	97%	27.46	491 / 504
skin	100%	4414.53	1808 / 1809	96%	42.79	451 / 472
kidney	100%	4081.69	89 / 89	95%	34.62	858 / 901
adrenal gland	100%	3085.02	258 / 258	92%	15.62	212 / 230
liver	97%	2073.86	219 / 226	72%	10.83	291 / 406
lymph node	0%	0	0 / 0	100%	27.48	29 / 29
spleen	100%	3603.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	39.23	45 / 45
adipose	100%	4136.47	1203 / 1204	0%	0	0 / 0
blood vessel	100%	3864.33	1333 / 1335	0%	0	0 / 0
muscle	100%	2592.26	799 / 803	0%	0	0 / 0
heart	99%	3557.86	849 / 861	0%	0	0 / 0
peripheral blood	93%	4050.62	862 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	93%	30.52	74 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

IV. Literature review

[source]

Gene name	AMD1
Protein name	Adenosylmethionine decarboxylase 1 (cDNA FLJ59608, highly similar to S-adenosylmethionine decarboxylase proenzyme) (cDNA, FLJ79370, highly similar to S-adenosylmethionine decarboxylase proenzyme) adenosylmethionine decarboxylase (EC 4.1.1.50) Adenosylmethionine decarboxylase 1 (cDNA FLJ52467, highly similar to S-adenosylmethionine decarboxylase proenzyme) Adenosylmethionine decarboxylase 1 S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SAMDC) (EC 4.1.1.50) [Cleaved into: S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain]
Synonyms	AMD
Description	FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. . FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. . FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. .
Accessions	ENST00000368877.9 B4DZ60 ENST00000368876.2 ENST00000368885.8 [P17707-1] ENST00000675380.1 ENST00000672937.2 F6R5I9 ENST00000368882.8 [P17707-1] A0A5F9ZHD5 ENST00000451850.6 P17707 Q5VXN5

GO_0008295	Biological process	spermidine biosynthetic process
GO_0006597	Biological process	spermine biosynthetic process
GO_0006595	Biological process	polyamine metabolic process
GO_0005829	Cellular component	cytosol
GO_0004014	Molecular function	adenosylmethionine decarboxylase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0019810	Molecular function	putrescine binding

AMD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review