heparan sulfate proteoglycan biosynthetic process

I. Involved cell types

Genes
Cell types
No. of supported studies
Group 13 studies
Group 210 studies
Group 35 studies
Group 47 studies
Group 524 studies

II. Literature review

[source]
Nameheparan sulfate proteoglycan biosynthetic process
IDGO_0015012
collection_id

Biological process

Exact synonym

heparan sulfate proteoglycan anabolism, heparan sulfate proteoglycan biosynthesis, heparan sulfate proteoglycan formation, heparan sulfate proteoglycan synthesis, heparan sulphate proteoglycan biosynthesis, heparan sulphate proteoglycan biosynthetic process

Description

The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.

Related synonym

heparin proteoglycan biosynthetic process

External URL
Genes