EXT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042044Biological processfluid transport
GO_0015014Biological processheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO_0030210Biological processheparin biosynthetic process
GO_0008217Biological processregulation of blood pressure
GO_0055078Biological processsodium ion homeostasis
GO_0002062Biological processchondrocyte differentiation
GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_0000271Biological processpolysaccharide biosynthetic process
GO_0051923Biological processsulfation
GO_0050891Biological processmulticellular organismal-level water homeostasis
GO_0060350Biological processendochondral bone morphogenesis
GO_0001707Biological processmesoderm formation
GO_0060047Biological processheart contraction
GO_0006024Biological processglycosaminoglycan biosynthetic process
GO_0010467Biological processgene expression
GO_0001503Biological processossification
GO_0006487Biological processprotein N-linked glycosylation
GO_0042311Biological processvasodilation
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_1902494Cellular componentcatalytic complex
GO_0016020Cellular componentmembrane
GO_0043541Cellular componentUDP-N-acetylglucosamine transferase complex
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0050508Molecular functionglucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO_0050509Molecular functionN-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
GO_0042328Molecular functionheparan sulfate N-acetylglucosaminyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0008375Molecular functionacetylglucosaminyltransferase activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016757Molecular functionglycosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXT2
Protein nameExostosin-2 (EC 2.4.1.224) (Exostosin glycosyltransferase 2) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 2)
Exostoses (Multiple) 2
Exostosin glycosyltransferase 2
Synonyms
DescriptionFUNCTION: Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone . Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity . Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling . .

AccessionsENST00000343631.4 [Q93063-1]
ENST00000358681.8 [Q93063-2]
ENST00000683870.1
A0A804HJW9
Q6NUL1
ENST00000684124.1
ENST00000684039.1
A0A804HL74
ENST00000682993.1 [Q93063-1]
Q93063
A0A804HLF7
ENST00000533608.7 [Q93063-1]
ENST00000682359.1
A0A804HIU8
A0A804HHX4
ENST00000682815.1
ENST00000683000.1 [Q93063-1]
A0A804HKG2
ENST00000395673.8 [Q93063-1]
ENST00000684533.1
A0A804HKG8
ENST00000682711.1