GLCE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031345Biological processnegative regulation of cell projection organization
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0030210Biological processheparin biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0042803Molecular functionprotein homodimerization activity
GO_0016857Molecular functionracemase and epimerase activity, acting on carbohydrates and derivatives
GO_0005509Molecular functioncalcium ion binding
GO_0047464Molecular functionheparosan-N-sulfate-glucuronate 5-epimerase activity

IV. Literature review

[source]
Gene nameGLCE
Protein nameheparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17)
D-glucuronyl C5-epimerase (EC 5.1.3.17) (Heparan sulfate C5-epimerase) (Hsepi) (Heparin/heparan sulfate:glucuronic acid C5-epimerase) (Heparosan-N-sulfate-glucuronate 5-epimerase)
SynonymsKIAA0836
DescriptionFUNCTION: Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. .

AccessionsH0YNP1
ENST00000261858.7
ENST00000559420.2
O94923