EXTL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EXTL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EXTL1 at tissue level.

III. Associated gene sets

GO_0001501Biological processskeletal system development
GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0005794Cellular componentGolgi apparatus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0008375Molecular functionacetylglucosaminyltransferase activity
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0050508Molecular functionglucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEXTL1
Protein nameExostosin-like 1 (EC 2.4.1.224) (Exostosin-L) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostosis-like protein)
SynonymsEXTL
DescriptionFUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS) . Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity) . Appears to lack GlcNAcT I and GlcAT-II activities . .

AccessionsQ92935
ENST00000374280.4