B3GAT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0005975Biological processcarbohydrate metabolic process
GO_0050650Biological processchondroitin sulfate proteoglycan biosynthetic process
GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_0006486Biological processprotein glycosylation
GO_0006024Biological processglycosaminoglycan biosynthetic process
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0050651Biological processdermatan sulfate proteoglycan biosynthetic process
GO_0043085Biological processpositive regulation of catalytic activity
GO_0000139Cellular componentGolgi membrane
GO_0005801Cellular componentcis-Golgi network
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0016020Cellular componentmembrane
GO_0015020Molecular functionglucuronosyltransferase activity
GO_0072542Molecular functionprotein phosphatase activator activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0015018Molecular functiongalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

IV. Literature review

[source]
Gene nameB3GAT3
Protein nameGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 3) (Glucuronosyltransferase I) (GlcAT-I) (UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) (GlcUAT-I)
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase (EC 2.4.1.135)
Beta-1,3-glucuronyltransferase 3
SynonymshCG_16017
DescriptionFUNCTION: Glycosaminoglycans biosynthesis . Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation . .

AccessionsE9PQ60
E9PNA1
G3V150
ENST00000534715.1
ENST00000534026.5 [O94766-2]
ENST00000532585.5
ENST00000531383.5
O94766
ENST00000265471.10 [O94766-1]
Q5U676