EXTL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030307Biological processpositive regulation of cell growth
GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0010838Biological processpositive regulation of keratinocyte proliferation
GO_0045617Biological processnegative regulation of keratinocyte differentiation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0106015Biological processnegative regulation of inflammatory response to wounding
GO_2000972Biological processpositive regulation of detection of glucose
GO_0006486Biological processprotein glycosylation
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0005634Cellular componentnucleus
GO_0000287Molecular functionmagnesium ion binding
GO_0016500Molecular functionprotein-hormone receptor activity
GO_0016757Molecular functionglycosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0001888Molecular functionglucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

IV. Literature review

[source]
Gene nameEXTL3
Protein nameExostosin like glycosyltransferase 3
Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3)
SynonymsEXTL1L
KIAA0519
EXTR1
DescriptionFUNCTION: Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS) . Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker . May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity) . Lacks glucuronyl transferase II (GlcAT-II) activity . Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) . Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion (By similarity). .; FUNCTION: Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway . Required for the function of REG3A in regulating keratinocyte proliferation and differentiation . Required for the inhibition of skin inflammation mediated by REGA through the activation of PI3K-AKT-STAT3 pathway . Required for the function of REGA and REG3G in glucose tolerance in pancreas . Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death (By similarity). .

AccessionsO43909
A0A8Q3SIB8
A0A8Q3SIF4
ENST00000696181.1
H0YB01
ENST00000696179.1
ENST00000696186.1
A0A8Q3SII2
ENST00000696178.1
ENST00000522698.1
ENST00000696182.1
ENST00000696184.1
H0YBJ7
ENST00000696177.1
ENST00000521473.5
A0A8Q3SIK7
ENST00000696180.1
ENST00000220562.9