NDST3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_0015014Biological processheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO_0030210Biological processheparin biosynthetic process
GO_0005575Cellular componentcellular_component
GO_0000139Cellular componentGolgi membrane
GO_0005794Cellular componentGolgi apparatus
GO_0015016Molecular function[heparan sulfate]-glucosamine N-sulfotransferase activity
GO_0102140Molecular functionheparan sulfate N-deacetylase activity
GO_0019213Molecular functiondeacetylase activity

IV. Literature review

[source]
Gene nameNDST3
Protein nameBifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)]
SynonymsHSST3
UNQ2544/PRO4998
DescriptionFUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity. .

AccessionsENST00000296499.6 [O95803-1]
O95803