EXTL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_0006044Biological processN-acetylglucosamine metabolic process
GO_0019276Biological processUDP-N-acetylgalactosamine metabolic process
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030145Molecular functionmanganese ion binding
GO_0035248Molecular functionalpha-1,4-N-acetylgalactosaminyltransferase activity
GO_0047237Molecular functionglucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0001888Molecular functionglucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO_0005539Molecular functionglycosaminoglycan binding

IV. Literature review

[source]
Gene nameEXTL2
Protein nameEXTL2
Exostoses (Multiple)-like 2
Exostosin like glycosyltransferase 2
Exostoses (Multiple)-like 2, isoform CRA_b (cDNA FLJ39595 fis, clone SKNSH2001931, highly similar to Exostoses)
EXTL2 protein
Exostosin-like 2 (EC 2.4.1.223) (Alpha-1,4-N-acetylhexosaminyltransferase EXTL2) (Alpha-GalNAcT EXTL2) (EXT-related protein 2) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) [Cleaved into: Processed exostosin-like 2]
SynonymshCG_32848
EXTR2
DescriptionFUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. .

AccessionsQ49A43
ENST00000370114.8
ENST00000416479.1
ENST00000535414.5
Q05DH5
Q8N8F1
Q8IYF4
ENST00000370113.7
Q9UBQ6
O00245
C9JEG3
C9IYF5
F5GZK1
ENST00000450240.2