XYLT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050650Biological processchondroitin sulfate proteoglycan biosynthetic process
GO_0030203Biological processglycosaminoglycan metabolic process
GO_0015012Biological processheparan sulfate proteoglycan biosynthetic process
GO_0030166Biological processproteoglycan biosynthetic process
GO_0030206Biological processchondroitin sulfate biosynthetic process
GO_0048706Biological processembryonic skeletal system development
GO_0043931Biological processossification involved in bone maturation
GO_0006024Biological processglycosaminoglycan biosynthetic process
GO_0005615Cellular componentextracellular space
GO_0000139Cellular componentGolgi membrane
GO_0000137Cellular componentGolgi cis cisterna
GO_0030158Molecular functionprotein xylosyltransferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameXYLT1
Protein nameXYLT1 protein
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)
Xylosyltransferase I
SynonymsXT1
DescriptionFUNCTION: Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein . Required for normal embryonic and postnatal skeleton development, especially of the long bones . Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity). .

AccessionsQ86Y38
ENST00000261381.7
A0A0C5BQN3
ENST00000671765.2
A0A0A7KW96