VPS36 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	18 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	14 studies	25% ± 6%	Explore
natural killer cell	13 studies	21% ± 4%	Explore
fibroblast	13 studies	22% ± 5%	Explore
B cell	13 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	13 studies	33% ± 8%	Explore
CD8-positive, alpha-beta T cell	11 studies	22% ± 4%	Explore
macrophage	11 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	21% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	21% ± 4%	Explore
retinal rod cell	8 studies	35% ± 6%	Explore
naive B cell	8 studies	19% ± 4%	Explore
regulatory T cell	8 studies	19% ± 3%	Explore
astrocyte	8 studies	28% ± 8%	Explore
gamma-delta T cell	8 studies	22% ± 10%	Explore
basal cell	7 studies	30% ± 13%	Explore
glutamatergic neuron	7 studies	40% ± 23%	Explore
mucosal invariant T cell	7 studies	18% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 6%	Explore
T cell	6 studies	17% ± 2%	Explore
classical monocyte	6 studies	25% ± 8%	Explore
mature NK T cell	6 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	19% ± 5%	Explore
microglial cell	6 studies	24% ± 6%	Explore
epithelial cell	6 studies	38% ± 11%	Explore
retinal cone cell	6 studies	34% ± 12%	Explore
GABAergic neuron	6 studies	38% ± 17%	Explore
oligodendrocyte	6 studies	23% ± 5%	Explore
memory B cell	6 studies	19% ± 1%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
type I pneumocyte	5 studies	19% ± 3%	Explore
oligodendrocyte precursor cell	5 studies	34% ± 9%	Explore
goblet cell	5 studies	25% ± 7%	Explore
pericyte	5 studies	18% ± 2%	Explore
interneuron	5 studies	38% ± 19%	Explore
hematopoietic precursor cell	4 studies	26% ± 12%	Explore
plasma cell	4 studies	28% ± 12%	Explore
plasmablast	4 studies	45% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 2%	Explore
secretory cell	4 studies	23% ± 6%	Explore
conventional dendritic cell	4 studies	34% ± 20%	Explore
exhausted T cell	4 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
non-classical monocyte	4 studies	27% ± 7%	Explore
neuron	4 studies	30% ± 10%	Explore
retinal bipolar neuron	4 studies	28% ± 2%	Explore
myeloid cell	4 studies	23% ± 8%	Explore
adipocyte	4 studies	21% ± 5%	Explore
ciliated cell	4 studies	27% ± 5%	Explore
myofibroblast cell	4 studies	19% ± 2%	Explore
dendritic cell	4 studies	34% ± 15%	Explore
smooth muscle cell	4 studies	18% ± 2%	Explore
hematopoietic stem cell	4 studies	19% ± 3%	Explore
glomerular endothelial cell	3 studies	18% ± 2%	Explore
amacrine cell	3 studies	22% ± 3%	Explore
retinal ganglion cell	3 studies	34% ± 12%	Explore
club cell	3 studies	21% ± 3%	Explore
immature B cell	3 studies	21% ± 2%	Explore
precursor B cell	3 studies	19% ± 2%	Explore
retina horizontal cell	3 studies	18% ± 1%	Explore
lymphocyte	3 studies	23% ± 3%	Explore
rod bipolar cell	3 studies	24% ± 5%	Explore
endothelial cell of vascular tree	3 studies	24% ± 6%	Explore
monocyte	3 studies	19% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 9%	Explore
transit amplifying cell	3 studies	31% ± 19%	Explore
mast cell	3 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	17% ± 2%	Explore
double negative thymocyte	3 studies	25% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	23% ± 8%	Explore
eye	8 studies	30% ± 6%	Explore
brain	8 studies	35% ± 16%	Explore
lung	6 studies	21% ± 6%	Explore
liver	4 studies	22% ± 6%	Explore
intestine	3 studies	22% ± 7%	Explore
adipose	3 studies	21% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3643.20	1445 / 1445	100%	27.63	183 / 183
lung	100%	3963.82	578 / 578	100%	21.69	1155 / 1155
breast	100%	4101.13	459 / 459	100%	23.64	1117 / 1118
intestine	100%	4471.68	966 / 966	100%	31.07	526 / 527
prostate	100%	4381.64	245 / 245	100%	25.07	501 / 502
stomach	100%	2708.17	359 / 359	100%	30.11	285 / 286
thymus	100%	4046.43	653 / 653	100%	22.91	602 / 605
kidney	100%	3197.29	89 / 89	99%	24.23	896 / 901
ovary	100%	3899.43	180 / 180	99%	12.89	427 / 430
bladder	100%	4293.81	21 / 21	99%	22.53	500 / 504
pancreas	100%	2262.68	327 / 328	99%	21.90	177 / 178
uterus	100%	4674.06	170 / 170	99%	19.88	455 / 459
brain	99%	2836.77	2607 / 2642	100%	18.34	705 / 705
skin	100%	5812.56	1809 / 1809	96%	24.22	451 / 472
adrenal gland	100%	2906.20	258 / 258	95%	16.16	218 / 230
liver	100%	1906.54	226 / 226	92%	11.20	375 / 406
adipose	100%	3563.33	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3425.18	1335 / 1335	0%	0	0 / 0
spleen	100%	4594.12	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	5.58	1 / 1
muscle	100%	2814.95	802 / 803	0%	0	0 / 0
heart	100%	2614.72	858 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	16.29	44 / 45
lymph node	0%	0	0 / 0	93%	15.57	27 / 29
eye	0%	0	0 / 0	91%	13.24	73 / 80
peripheral blood	66%	1261.43	614 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043328	Biological process	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0016236	Biological process	macroautophagy
GO_0036258	Biological process	multivesicular body assembly
GO_0090148	Biological process	membrane fission
GO_0005764	Cellular component	lysosome
GO_0070062	Cellular component	extracellular exosome
GO_0005768	Cellular component	endosome
GO_0031902	Cellular component	late endosome membrane
GO_0005829	Cellular component	cytosol
GO_0000814	Cellular component	ESCRT II complex
GO_0005634	Cellular component	nucleus
GO_0032266	Molecular function	phosphatidylinositol-3-phosphate binding
GO_0005515	Molecular function	protein binding
GO_0043130	Molecular function	ubiquitin binding

IV. Literature review

[source]

Gene name	VPS36
Protein name	Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36) Vacuolar protein-sorting-associated protein 36 (ESCRT-II complex subunit VPS36)
Synonyms	C13orf9 CGI-145 EAP45
Description	FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. FUNCTION: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. .
Accessions	ENST00000378060.9 [Q86VN1-1] Q86VN1 A0A3B3ISW7 ENST00000611132.4 [Q86VN1-2] ENST00000650274.1

VPS36 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review