UBE2V1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_1902523Biological processpositive regulation of protein K63-linked ubiquitination
GO_0006282Biological processregulation of DNA repair
GO_1902533Biological processpositive regulation of intracellular signal transduction
GO_0006301Biological processpostreplication repair
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0030154Biological processcell differentiation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0000151Cellular componentubiquitin ligase complex
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031371Cellular componentubiquitin conjugating enzyme complex
GO_0005737Cellular componentcytoplasm
GO_0031372Cellular componentUBC13-MMS2 complex
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE2V1
Protein nameHCG2018358, isoform CRA_d (Ubiquitin conjugating enzyme E2 V1)
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)
Ubiquitin-conjugating enzyme E2 variant 1
SynonymsP/OKcl.19
CROC1
UBE2V
UEV1
hCG_2018358
DescriptionFUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production . UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. .

AccessionsENST00000557021.5
G3V2F7
ENST00000371677.7 [Q13404-7]
ENST00000371674.8 [Q13404-4]
ENST00000617119.4
ENST00000371657.9 [Q13404-8]
ENST00000483534.5
ENST00000625172.3
ENST00000340309.7 [Q13404-7]
ENST00000415862.6 [Q13404-6]
D6RG00
Q13404