UBE2E3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	30 studies	29% ± 13%	Explore
fibroblast	30 studies	29% ± 12%	Explore
natural killer cell	24 studies	22% ± 6%	Explore
pericyte	17 studies	30% ± 13%	Explore
plasmacytoid dendritic cell	14 studies	27% ± 9%	Explore
oligodendrocyte precursor cell	14 studies	41% ± 16%	Explore
smooth muscle cell	14 studies	31% ± 13%	Explore
astrocyte	13 studies	37% ± 14%	Explore
basal cell	12 studies	30% ± 16%	Explore
myofibroblast cell	12 studies	36% ± 15%	Explore
connective tissue cell	11 studies	44% ± 18%	Explore
glutamatergic neuron	11 studies	47% ± 22%	Explore
macrophage	11 studies	26% ± 7%	Explore
microglial cell	11 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	11 studies	26% ± 8%	Explore
oligodendrocyte	11 studies	35% ± 11%	Explore
neuron	10 studies	47% ± 22%	Explore
epithelial cell	9 studies	39% ± 20%	Explore
classical monocyte	8 studies	20% ± 6%	Explore
GABAergic neuron	8 studies	40% ± 16%	Explore
B cell	8 studies	22% ± 8%	Explore
CD8-positive, alpha-beta T cell	8 studies	22% ± 5%	Explore
mesothelial cell	8 studies	41% ± 17%	Explore
vein endothelial cell	8 studies	25% ± 9%	Explore
ciliated cell	8 studies	30% ± 13%	Explore
adipocyte	8 studies	27% ± 7%	Explore
non-classical monocyte	7 studies	26% ± 11%	Explore
platelet	7 studies	25% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	26% ± 5%	Explore
mature NK T cell	7 studies	18% ± 3%	Explore
kidney loop of Henle epithelial cell	7 studies	24% ± 4%	Explore
endothelial cell of artery	7 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	21% ± 3%	Explore
abnormal cell	6 studies	31% ± 7%	Explore
interneuron	6 studies	45% ± 16%	Explore
club cell	6 studies	22% ± 5%	Explore
retinal rod cell	6 studies	33% ± 17%	Explore
gamma-delta T cell	6 studies	28% ± 16%	Explore
leukocyte	5 studies	21% ± 2%	Explore
progenitor cell	5 studies	39% ± 10%	Explore
retinal bipolar neuron	5 studies	40% ± 15%	Explore
OFF-bipolar cell	5 studies	38% ± 11%	Explore
ON-bipolar cell	5 studies	41% ± 11%	Explore
retinal ganglion cell	5 studies	46% ± 21%	Explore
hematopoietic stem cell	5 studies	23% ± 5%	Explore
precursor B cell	5 studies	32% ± 10%	Explore
capillary endothelial cell	5 studies	25% ± 10%	Explore
amacrine cell	5 studies	47% ± 12%	Explore
retina horizontal cell	5 studies	34% ± 14%	Explore
retinal cone cell	5 studies	38% ± 16%	Explore
endothelial cell of vascular tree	5 studies	22% ± 7%	Explore
hematopoietic precursor cell	4 studies	37% ± 17%	Explore
secretory cell	4 studies	26% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	4 studies	22% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	38% ± 19%	Explore
epithelial cell of proximal tubule	4 studies	22% ± 6%	Explore
T cell	4 studies	31% ± 17%	Explore
glial cell	4 studies	39% ± 24%	Explore
granule cell	4 studies	35% ± 13%	Explore
megakaryocyte	4 studies	29% ± 10%	Explore
pro-B cell	4 studies	33% ± 6%	Explore
myeloid cell	4 studies	23% ± 6%	Explore
plasma cell	4 studies	23% ± 12%	Explore
retinal pigment epithelial cell	4 studies	29% ± 14%	Explore
monocyte	4 studies	21% ± 5%	Explore
Mueller cell	4 studies	25% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	19% ± 2%	Explore
hepatocyte	4 studies	35% ± 18%	Explore
type I pneumocyte	4 studies	24% ± 6%	Explore
enteroendocrine cell	4 studies	28% ± 16%	Explore
goblet cell	4 studies	30% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 1%	Explore
mucosal invariant T cell	4 studies	16% ± 1%	Explore
precursor cell	3 studies	47% ± 19%	Explore
pancreatic A cell	3 studies	37% ± 12%	Explore
neural crest cell	3 studies	58% ± 15%	Explore
GABAergic interneuron	3 studies	25% ± 7%	Explore
lymphocyte	3 studies	26% ± 4%	Explore
brush cell	3 studies	30% ± 11%	Explore
type II pneumocyte	3 studies	22% ± 5%	Explore
mononuclear phagocyte	3 studies	28% ± 12%	Explore
GABAergic amacrine cell	3 studies	31% ± 6%	Explore
glycinergic amacrine cell	3 studies	36% ± 12%	Explore
rod bipolar cell	3 studies	24% ± 1%	Explore
muscle cell	3 studies	29% ± 10%	Explore
pancreatic ductal cell	3 studies	42% ± 9%	Explore
mast cell	3 studies	22% ± 5%	Explore
intestinal crypt stem cell	3 studies	24% ± 1%	Explore
respiratory goblet cell	3 studies	24% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 12%	Explore
melanocyte	3 studies	24% ± 4%	Explore
transit amplifying cell	3 studies	25% ± 11%	Explore
keratinocyte	3 studies	19% ± 2%	Explore
erythrocyte	3 studies	33% ± 20%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	36% ± 18%	Explore
eye	9 studies	30% ± 11%	Explore
lung	9 studies	32% ± 15%	Explore
peripheral blood	7 studies	20% ± 6%	Explore
kidney	7 studies	22% ± 8%	Explore
intestine	5 studies	37% ± 16%	Explore
liver	4 studies	36% ± 22%	Explore
adipose	4 studies	25% ± 9%	Explore
pancreas	3 studies	38% ± 6%	Explore
bone marrow	3 studies	22% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2271.78	1445 / 1445	100%	70.60	183 / 183
ovary	100%	2587.57	180 / 180	100%	97.78	430 / 430
pancreas	100%	1911.11	328 / 328	100%	66.86	178 / 178
uterus	100%	2645.41	170 / 170	100%	81.33	459 / 459
brain	100%	3391.44	2641 / 2642	100%	84.54	705 / 705
intestine	100%	2629.81	966 / 966	100%	52.25	526 / 527
bladder	100%	3283.57	21 / 21	100%	64.56	503 / 504
thymus	100%	3699.48	653 / 653	100%	72.36	603 / 605
prostate	100%	2313.88	245 / 245	100%	78.08	500 / 502
lung	100%	2524.28	577 / 578	100%	65.22	1150 / 1155
kidney	100%	3281.46	89 / 89	99%	56.87	895 / 901
stomach	100%	2556.57	359 / 359	99%	50.36	283 / 286
skin	100%	3801.69	1809 / 1809	99%	71.50	466 / 472
liver	100%	1516.65	226 / 226	98%	35.48	398 / 406
adrenal gland	100%	2660.83	258 / 258	95%	41.12	218 / 230
breast	100%	3431.83	459 / 459	90%	45.02	1011 / 1118
adipose	100%	3362.71	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	45.50	29 / 29
muscle	100%	4214.71	803 / 803	0%	0	0 / 0
spleen	100%	2480.25	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	62.00	45 / 45
ureter	0%	0	0 / 0	100%	33.96	1 / 1
blood vessel	100%	3157.66	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	43.30	79 / 80
heart	98%	1967.38	844 / 861	0%	0	0 / 0
peripheral blood	95%	1436.63	879 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0070534	Biological process	protein K63-linked ubiquitination
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0061631	Molecular function	ubiquitin conjugating enzyme activity
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	UBE2E3
Protein name	Ubiquitin conjugating enzyme E2 E3 Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3) E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
Synonyms	UBCH9 UBCE4
Description	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. .
Accessions	ENST00000410062.9 ENST00000602710.5 R4GN77 A0A1B0GX65 ENST00000602479.5 ENST00000602291.5 ENST00000602632.1 R4GND1 ENST00000602303.5 R4GMM6 R4GNG6 ENST00000392415.6 ENST00000602959.5 ENST00000602499.5 ENST00000602475.5 Q969T4

UBE2E3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review