TMEM165 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	43 studies	35% ± 12%	Explore
fibroblast	41 studies	34% ± 14%	Explore
pericyte	32 studies	33% ± 14%	Explore
macrophage	29 studies	29% ± 14%	Explore
smooth muscle cell	28 studies	30% ± 9%	Explore
B cell	23 studies	22% ± 7%	Explore
natural killer cell	21 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	20 studies	28% ± 9%	Explore
basal cell	19 studies	37% ± 18%	Explore
classical monocyte	19 studies	25% ± 11%	Explore
epithelial cell	16 studies	41% ± 24%	Explore
oligodendrocyte	16 studies	72% ± 20%	Explore
T cell	15 studies	21% ± 6%	Explore
monocyte	15 studies	30% ± 12%	Explore
non-classical monocyte	15 studies	27% ± 14%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 5%	Explore
conventional dendritic cell	14 studies	25% ± 15%	Explore
endothelial cell of vascular tree	14 studies	31% ± 12%	Explore
myeloid cell	14 studies	30% ± 11%	Explore
ciliated cell	13 studies	37% ± 18%	Explore
capillary endothelial cell	13 studies	29% ± 5%	Explore
astrocyte	13 studies	31% ± 11%	Explore
microglial cell	13 studies	33% ± 12%	Explore
connective tissue cell	13 studies	30% ± 10%	Explore
myofibroblast cell	12 studies	29% ± 10%	Explore
vein endothelial cell	12 studies	30% ± 12%	Explore
type I pneumocyte	11 studies	36% ± 11%	Explore
CD4-positive, alpha-beta T cell	11 studies	19% ± 4%	Explore
endothelial cell of artery	11 studies	29% ± 5%	Explore
type II pneumocyte	10 studies	40% ± 14%	Explore
plasma cell	10 studies	28% ± 12%	Explore
club cell	10 studies	44% ± 15%	Explore
secretory cell	10 studies	46% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	19% ± 4%	Explore
mature NK T cell	10 studies	18% ± 2%	Explore
gamma-delta T cell	10 studies	23% ± 8%	Explore
memory B cell	10 studies	19% ± 4%	Explore
dendritic cell	10 studies	37% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	20% ± 4%	Explore
naive B cell	9 studies	21% ± 4%	Explore
mast cell	9 studies	25% ± 8%	Explore
adipocyte	9 studies	43% ± 10%	Explore
regulatory T cell	9 studies	19% ± 3%	Explore
oligodendrocyte precursor cell	9 studies	32% ± 13%	Explore
plasmacytoid dendritic cell	9 studies	24% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	20% ± 3%	Explore
respiratory goblet cell	8 studies	46% ± 12%	Explore
GABAergic neuron	8 studies	40% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
abnormal cell	7 studies	23% ± 7%	Explore
neuron	6 studies	33% ± 19%	Explore
lymphocyte	6 studies	30% ± 11%	Explore
innate lymphoid cell	6 studies	19% ± 3%	Explore
alveolar macrophage	6 studies	33% ± 16%	Explore
mesothelial cell	6 studies	38% ± 16%	Explore
mononuclear phagocyte	6 studies	33% ± 13%	Explore
goblet cell	6 studies	43% ± 25%	Explore
hematopoietic precursor cell	5 studies	30% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 4%	Explore
leukocyte	5 studies	25% ± 8%	Explore
glutamatergic neuron	5 studies	53% ± 22%	Explore
adventitial cell	5 studies	30% ± 8%	Explore
cardiac muscle cell	5 studies	23% ± 3%	Explore
plasmablast	4 studies	48% ± 17%	Explore
duct epithelial cell	4 studies	34% ± 12%	Explore
squamous epithelial cell	4 studies	44% ± 23%	Explore
exhausted T cell	4 studies	20% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	17% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	18% ± 3%	Explore
glial cell	4 studies	34% ± 15%	Explore
Mueller cell	4 studies	28% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	43% ± 10%	Explore
luminal cell of prostate epithelium	4 studies	29% ± 8%	Explore
enteroendocrine cell	4 studies	24% ± 10%	Explore
mucus secreting cell	4 studies	29% ± 12%	Explore
keratinocyte	4 studies	28% ± 12%	Explore
T-helper 17 cell	4 studies	18% ± 2%	Explore
interneuron	4 studies	44% ± 17%	Explore
T follicular helper cell	4 studies	17% ± 3%	Explore
hillock cell	3 studies	26% ± 8%	Explore
ionocyte	3 studies	28% ± 7%	Explore
pancreatic A cell	3 studies	26% ± 8%	Explore
glomerular endothelial cell	3 studies	25% ± 6%	Explore
GABAergic interneuron	3 studies	18% ± 2%	Explore
retinal ganglion cell	3 studies	29% ± 6%	Explore
brush cell	3 studies	29% ± 9%	Explore
immature B cell	3 studies	23% ± 8%	Explore
amacrine cell	3 studies	27% ± 4%	Explore
retina horizontal cell	3 studies	24% ± 4%	Explore
retinal pigment epithelial cell	3 studies	45% ± 24%	Explore
retinal rod cell	3 studies	23% ± 3%	Explore
tissue-resident macrophage	3 studies	28% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 8%	Explore
muscle cell	3 studies	47% ± 12%	Explore
pancreatic ductal cell	3 studies	40% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 9%	Explore
transit amplifying cell	3 studies	40% ± 29%	Explore
myoepithelial cell	3 studies	29% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	34% ± 15%	Explore
brain	16 studies	41% ± 20%	Explore
peripheral blood	7 studies	27% ± 11%	Explore
eye	6 studies	30% ± 18%	Explore
heart	5 studies	26% ± 4%	Explore
breast	5 studies	28% ± 8%	Explore
intestine	5 studies	23% ± 11%	Explore
liver	5 studies	27% ± 11%	Explore
kidney	4 studies	19% ± 2%	Explore
placenta	4 studies	25% ± 11%	Explore
uterus	4 studies	32% ± 16%	Explore
prostate	4 studies	33% ± 10%	Explore
adipose	4 studies	36% ± 18%	Explore
pancreas	3 studies	30% ± 9%	Explore
bone marrow	3 studies	23% ± 10%	Explore
lymph node	3 studies	18% ± 2%	Explore
esophagus	3 studies	35% ± 18%	Explore
skin	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4377.33	21 / 21	100%	55.01	504 / 504
breast	100%	4178.88	459 / 459	100%	46.00	1118 / 1118
esophagus	100%	4510.69	1445 / 1445	100%	45.00	183 / 183
intestine	100%	3180.74	966 / 966	100%	41.28	527 / 527
lung	100%	6580.97	578 / 578	100%	61.72	1155 / 1155
ovary	100%	2606.69	180 / 180	100%	44.07	430 / 430
stomach	100%	2966.49	359 / 359	100%	37.35	286 / 286
uterus	100%	3647.11	170 / 170	100%	52.44	459 / 459
prostate	100%	4163.95	245 / 245	100%	36.18	500 / 502
thymus	100%	3762.68	653 / 653	99%	30.48	600 / 605
kidney	100%	2885.63	89 / 89	99%	27.14	892 / 901
pancreas	100%	2589.06	328 / 328	99%	46.17	176 / 178
brain	99%	2852.31	2615 / 2642	99%	31.27	701 / 705
adrenal gland	100%	5887.01	258 / 258	97%	25.71	224 / 230
skin	100%	4292.85	1809 / 1809	96%	29.77	455 / 472
liver	62%	856.50	139 / 226	67%	11.17	272 / 406
adipose	100%	5025.48	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	27.73	29 / 29
spleen	100%	4267.33	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	43.25	45 / 45
ureter	0%	0	0 / 0	100%	44.66	1 / 1
blood vessel	100%	3984.59	1334 / 1335	0%	0	0 / 0
heart	98%	2526.09	843 / 861	0%	0	0 / 0
muscle	73%	906.37	589 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	68%	14.07	54 / 80
peripheral blood	64%	1725.19	597 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006874	Biological process	intracellular calcium ion homeostasis
GO_0071421	Biological process	manganese ion transmembrane transport
GO_0032468	Biological process	Golgi calcium ion homeostasis
GO_0035751	Biological process	regulation of lysosomal lumen pH
GO_0032472	Biological process	Golgi calcium ion transport
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0006487	Biological process	protein N-linked glycosylation
GO_0006816	Biological process	calcium ion transport
GO_0006828	Biological process	manganese ion transport
GO_0005794	Cellular component	Golgi apparatus
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0000139	Cellular component	Golgi membrane
GO_0033106	Cellular component	cis-Golgi network membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0010008	Cellular component	endosome membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0015085	Molecular function	calcium ion transmembrane transporter activity
GO_0015297	Molecular function	antiporter activity
GO_0005384	Molecular function	manganese ion transmembrane transporter activity

IV. Literature review

[source]

Gene name	TMEM165
Protein name	Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL) Transmembrane protein 165 GDT1 family protein
Synonyms	TPARL
Description	FUNCTION: Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated. .
Accessions	ENST00000381334.10 [Q9HC07-1] D6RD79 D6RBL0 ENST00000508404.5 ENST00000506103.2 Q9HC07 V9GYC8 V9GY93 ENST00000608091.1 ENST00000506198.5

TMEM165 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review