TBC1D5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090630Biological processactivation of GTPase activity
GO_0016236Biological processmacroautophagy
GO_1902017Biological processregulation of cilium assembly
GO_0002092Biological processpositive regulation of receptor internalization
GO_0042594Biological processresponse to starvation
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0015031Biological processprotein transport
GO_0006914Biological processautophagy
GO_0030122Cellular componentAP-2 adaptor complex
GO_0005794Cellular componentGolgi apparatus
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_1990316Cellular componentAtg1/ULK1 kinase complex
GO_0005776Cellular componentautophagosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_1905394Molecular functionretromer complex binding
GO_0035612Molecular functionAP-2 adaptor complex binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0005096Molecular functionGTPase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTBC1D5
Protein nameTBC1 domain family member 5
TBC1 domain family, member 5
SynonymsKIAA0210
DescriptionFUNCTION: May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity . Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy . May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes . .

AccessionsF2Z3C3
ENST00000444471.5
Q92609
C9JIU4
ENST00000445294.5
C9JDR8
ENST00000452492.6
C9JNM0
C9JWX0
ENST00000507877.5
ENST00000434420.1
ENST00000430169.5
ENST00000433533.5
ENST00000446818.6 [Q92609-2]
B9A6K1
C9J3F6
ENST00000428355.5
C9JW04
ENST00000446863.5
C9JMP7
ENST00000429924.6
C9J397
ENST00000696125.1 [Q92609-2]
ENST00000429383.8 [Q92609-1]
ENST00000253692.11 [Q92609-1]
C9K0P2
C9JED7
F2Z3I5
ENST00000415814.6
ENST00000425944.5
ENST00000414349.5
ENST00000412981.5