SRSF6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	24 studies	23% ± 7%	Explore
endothelial cell	18 studies	26% ± 11%	Explore
pericyte	11 studies	24% ± 10%	Explore
smooth muscle cell	11 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	11 studies	25% ± 10%	Explore
mast cell	11 studies	21% ± 6%	Explore
T cell	10 studies	22% ± 7%	Explore
natural killer cell	10 studies	22% ± 5%	Explore
ciliated cell	9 studies	29% ± 14%	Explore
classical monocyte	9 studies	23% ± 9%	Explore
B cell	9 studies	31% ± 12%	Explore
basal cell	9 studies	27% ± 15%	Explore
endothelial cell of lymphatic vessel	8 studies	19% ± 3%	Explore
naive B cell	8 studies	21% ± 6%	Explore
connective tissue cell	8 studies	28% ± 11%	Explore
epithelial cell	8 studies	38% ± 24%	Explore
myofibroblast cell	7 studies	24% ± 5%	Explore
macrophage	7 studies	20% ± 5%	Explore
oligodendrocyte precursor cell	7 studies	33% ± 11%	Explore
non-classical monocyte	6 studies	25% ± 11%	Explore
CD4-positive, alpha-beta T cell	6 studies	25% ± 5%	Explore
CD8-positive, alpha-beta T cell	6 studies	21% ± 3%	Explore
conventional dendritic cell	6 studies	30% ± 14%	Explore
gamma-delta T cell	5 studies	30% ± 14%	Explore
platelet	5 studies	18% ± 2%	Explore
type I pneumocyte	5 studies	25% ± 5%	Explore
type II pneumocyte	5 studies	21% ± 6%	Explore
regulatory T cell	5 studies	19% ± 2%	Explore
neuron	5 studies	32% ± 20%	Explore
astrocyte	5 studies	29% ± 5%	Explore
oligodendrocyte	5 studies	28% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	23% ± 4%	Explore
hematopoietic precursor cell	4 studies	34% ± 14%	Explore
memory B cell	4 studies	27% ± 8%	Explore
microglial cell	4 studies	17% ± 2%	Explore
precursor B cell	4 studies	30% ± 16%	Explore
endothelial cell of vascular tree	4 studies	23% ± 7%	Explore
innate lymphoid cell	4 studies	26% ± 8%	Explore
myeloid cell	4 studies	29% ± 10%	Explore
monocyte	4 studies	28% ± 11%	Explore
adipocyte	4 studies	27% ± 9%	Explore
mesothelial cell	4 studies	28% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	23% ± 5%	Explore
endothelial cell of artery	4 studies	19% ± 1%	Explore
hepatocyte	4 studies	36% ± 20%	Explore
GABAergic neuron	4 studies	35% ± 6%	Explore
glutamatergic neuron	4 studies	41% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	25% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	29% ± 6%	Explore
mature NK T cell	3 studies	20% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	25% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	29% ± 7%	Explore
progenitor cell	3 studies	20% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	24% ± 2%	Explore
abnormal cell	3 studies	31% ± 7%	Explore
neural crest cell	3 studies	20% ± 3%	Explore
brush cell	3 studies	29% ± 10%	Explore
club cell	3 studies	27% ± 9%	Explore
secretory cell	3 studies	24% ± 8%	Explore
acinar cell	3 studies	33% ± 12%	Explore
capillary endothelial cell	3 studies	16% ± 0%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 7%	Explore
vein endothelial cell	3 studies	17% ± 2%	Explore
dendritic cell	3 studies	39% ± 21%	Explore
enteroendocrine cell	3 studies	34% ± 19%	Explore
goblet cell	3 studies	31% ± 10%	Explore
leukocyte	3 studies	24% ± 5%	Explore
T follicular helper cell	3 studies	20% ± 2%	Explore
transit amplifying cell	3 studies	21% ± 3%	Explore
keratinocyte	3 studies	18% ± 2%	Explore
interneuron	3 studies	34% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	28% ± 13%	Explore
brain	7 studies	31% ± 9%	Explore
peripheral blood	6 studies	33% ± 13%	Explore
intestine	4 studies	31% ± 17%	Explore
uterus	4 studies	27% ± 11%	Explore
kidney	3 studies	19% ± 3%	Explore
eye	3 studies	26% ± 4%	Explore
breast	3 studies	18% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	10541.10	21 / 21	100%	93.11	504 / 504
breast	100%	13558.49	459 / 459	100%	113.95	1118 / 1118
liver	100%	10946.73	226 / 226	100%	49.65	406 / 406
ovary	100%	18803.20	180 / 180	100%	76.62	430 / 430
pancreas	100%	12182.99	328 / 328	100%	70.43	178 / 178
uterus	100%	15239.73	170 / 170	100%	99.02	459 / 459
lung	100%	10531.61	577 / 578	100%	82.30	1155 / 1155
intestine	100%	12019.80	966 / 966	100%	83.40	526 / 527
prostate	100%	17745.05	245 / 245	100%	127.08	501 / 502
thymus	100%	19711.84	653 / 653	100%	98.48	603 / 605
stomach	100%	11195.30	359 / 359	100%	77.21	285 / 286
adrenal gland	100%	16761.16	258 / 258	100%	74.37	229 / 230
esophagus	100%	9750.00	1445 / 1445	99%	61.57	182 / 183
skin	100%	12002.18	1809 / 1809	99%	79.36	466 / 472
kidney	100%	11834.46	89 / 89	99%	64.04	888 / 901
brain	98%	6580.07	2601 / 2642	100%	95.41	705 / 705
adipose	100%	11911.34	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	82.40	29 / 29
spleen	100%	18927.87	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	78.24	45 / 45
ureter	0%	0	0 / 0	100%	31.71	1 / 1
blood vessel	100%	7496.46	1330 / 1335	0%	0	0 / 0
heart	99%	6406.77	856 / 861	0%	0	0 / 0
muscle	97%	4252.62	778 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	94%	57.67	75 / 80
peripheral blood	78%	4832.27	724 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0045617	Biological process	negative regulation of keratinocyte differentiation
GO_0032868	Biological process	response to insulin
GO_0006376	Biological process	mRNA splice site recognition
GO_0048025	Biological process	negative regulation of mRNA splicing, via spliceosome
GO_2000675	Biological process	negative regulation of type B pancreatic cell apoptotic process
GO_0060501	Biological process	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO_0010837	Biological process	regulation of keratinocyte proliferation
GO_0061041	Biological process	regulation of wound healing
GO_0000381	Biological process	regulation of alternative mRNA splicing, via spliceosome
GO_0000380	Biological process	alternative mRNA splicing, via spliceosome
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0036002	Molecular function	pre-mRNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SRSF6
Protein name	Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6) Serine and arginine rich splicing factor 6 Alternative protein SRSF6
Synonyms	SRP55 SFRS6
Description	FUNCTION: Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. .
Accessions	ENST00000662078.1 A0A590UK01 L0R6Q2 ENST00000670741.1 A0A590UJP7 A0A590UJK4 ENST00000483871.6 [Q13247-2] ENST00000244020.5 [Q13247-1] Q13247 ENST00000668808.1

SRSF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review