SRPRA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	18 studies	25% ± 6%	Explore
regulatory T cell	18 studies	23% ± 6%	Explore
plasma cell	17 studies	41% ± 14%	Explore
plasmacytoid dendritic cell	17 studies	38% ± 10%	Explore
B cell	15 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	15 studies	25% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	25% ± 5%	Explore
CD4-positive, alpha-beta T cell	13 studies	23% ± 6%	Explore
naive B cell	12 studies	22% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	24% ± 4%	Explore
gamma-delta T cell	12 studies	28% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	25% ± 6%	Explore
memory B cell	11 studies	22% ± 4%	Explore
plasmablast	10 studies	50% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	23% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	24% ± 3%	Explore
mucosal invariant T cell	10 studies	31% ± 7%	Explore
T cell	9 studies	20% ± 2%	Explore
fibroblast	9 studies	24% ± 8%	Explore
mature NK T cell	9 studies	25% ± 5%	Explore
endothelial cell	8 studies	23% ± 5%	Explore
classical monocyte	8 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	26% ± 6%	Explore
non-classical monocyte	7 studies	23% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	24% ± 5%	Explore
T follicular helper cell	6 studies	21% ± 3%	Explore
mast cell	5 studies	20% ± 3%	Explore
pericyte	5 studies	20% ± 6%	Explore
epithelial cell	5 studies	33% ± 19%	Explore
macrophage	5 studies	18% ± 2%	Explore
IgA plasma cell	5 studies	26% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 5%	Explore
IgG plasma cell	5 studies	23% ± 11%	Explore
basal cell	4 studies	24% ± 13%	Explore
secretory cell	4 studies	29% ± 10%	Explore
conventional dendritic cell	4 studies	32% ± 11%	Explore
precursor B cell	4 studies	22% ± 3%	Explore
myeloid cell	4 studies	28% ± 8%	Explore
ciliated cell	4 studies	27% ± 12%	Explore
innate lymphoid cell	4 studies	23% ± 4%	Explore
dendritic cell	4 studies	32% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 5%	Explore
type I pneumocyte	3 studies	20% ± 2%	Explore
club cell	3 studies	24% ± 9%	Explore
respiratory goblet cell	3 studies	32% ± 16%	Explore
leukocyte	3 studies	23% ± 8%	Explore
hematopoietic precursor cell	3 studies	25% ± 5%	Explore
retinal ganglion cell	3 studies	36% ± 13%	Explore
immature B cell	3 studies	22% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
exhausted T cell	3 studies	22% ± 2%	Explore
glutamatergic neuron	3 studies	28% ± 9%	Explore
T-helper 1 cell	3 studies	21% ± 3%	Explore
hematopoietic stem cell	3 studies	20% ± 2%	Explore
double negative thymocyte	3 studies	29% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	24% ± 3%	Explore
lung	4 studies	27% ± 11%	Explore
bone marrow	3 studies	24% ± 3%	Explore
brain	3 studies	21% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7329.60	1445 / 1445	100%	176.13	183 / 183
lung	100%	10198.84	578 / 578	100%	164.57	1155 / 1155
ovary	100%	8101.04	180 / 180	100%	149.76	430 / 430
pancreas	100%	20005.75	328 / 328	100%	143.82	178 / 178
prostate	100%	10392.44	245 / 245	100%	237.91	502 / 502
stomach	100%	10529.56	359 / 359	100%	139.08	286 / 286
breast	100%	9159.77	459 / 459	100%	161.17	1117 / 1118
intestine	100%	7482.65	966 / 966	100%	136.12	526 / 527
skin	100%	9037.66	1809 / 1809	100%	180.20	471 / 472
uterus	100%	9193.45	170 / 170	100%	112.98	458 / 459
thymus	100%	10414.40	653 / 653	100%	146.88	603 / 605
kidney	100%	6640.10	89 / 89	100%	121.50	898 / 901
liver	100%	12517.67	226 / 226	100%	131.71	404 / 406
bladder	100%	8541.48	21 / 21	99%	128.36	501 / 504
adrenal gland	100%	11113.38	258 / 258	99%	116.29	227 / 230
brain	92%	3384.47	2423 / 2642	99%	65.40	701 / 705
adipose	100%	8932.87	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	150.04	80 / 80
lymph node	0%	0	0 / 0	100%	135.20	29 / 29
muscle	100%	7655.50	803 / 803	0%	0	0 / 0
spleen	100%	9861.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	98.20	45 / 45
ureter	0%	0	0 / 0	100%	58.18	1 / 1
blood vessel	100%	9014.00	1334 / 1335	0%	0	0 / 0
heart	98%	5884.98	848 / 861	0%	0	0 / 0
peripheral blood	98%	7428.36	906 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045047	Biological process	protein targeting to ER
GO_0006886	Biological process	intracellular protein transport
GO_0006613	Biological process	cotranslational protein targeting to membrane
GO_0006617	Biological process	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO_0005785	Cellular component	signal recognition particle receptor complex
GO_0070062	Cellular component	extracellular exosome
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0003723	Molecular function	RNA binding
GO_0005525	Molecular function	GTP binding
GO_0005047	Molecular function	signal recognition particle binding
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	SRPRA
Protein name	Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha) SRPR protein
Synonyms	SRPR
Description	FUNCTION: Component of the signal recognition particle (SRP) complex receptor (SR) . Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system . Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 . SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER . .
Accessions	ENST00000532259.1 [P08240-2] ENST00000332118.11 [P08240-1] Q6IAX9 P08240

SRPRA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review