SPINT2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
conventional dendritic cell	28 studies	48% ± 15%	Explore
B cell	27 studies	24% ± 8%	Explore
macrophage	25 studies	29% ± 11%	Explore
epithelial cell	23 studies	71% ± 23%	Explore
plasmacytoid dendritic cell	22 studies	57% ± 13%	Explore
basal cell	20 studies	66% ± 22%	Explore
dendritic cell	18 studies	48% ± 21%	Explore
mast cell	17 studies	33% ± 12%	Explore
memory B cell	16 studies	24% ± 5%	Explore
ciliated cell	16 studies	72% ± 16%	Explore
naive B cell	15 studies	25% ± 5%	Explore
fibroblast	11 studies	36% ± 21%	Explore
secretory cell	11 studies	81% ± 13%	Explore
classical monocyte	11 studies	26% ± 10%	Explore
goblet cell	11 studies	57% ± 20%	Explore
plasma cell	10 studies	38% ± 16%	Explore
myeloid cell	10 studies	30% ± 13%	Explore
monocyte	9 studies	27% ± 10%	Explore
type I pneumocyte	8 studies	68% ± 21%	Explore
type II pneumocyte	8 studies	66% ± 26%	Explore
club cell	8 studies	73% ± 21%	Explore
platelet	8 studies	38% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	25% ± 6%	Explore
hematopoietic stem cell	8 studies	52% ± 15%	Explore
brush cell	8 studies	53% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
ionocyte	7 studies	68% ± 15%	Explore
respiratory goblet cell	7 studies	64% ± 25%	Explore
epithelial cell of proximal tubule	7 studies	38% ± 21%	Explore
abnormal cell	7 studies	49% ± 28%	Explore
enterocyte	7 studies	64% ± 22%	Explore
progenitor cell	7 studies	70% ± 21%	Explore
precursor B cell	7 studies	46% ± 16%	Explore
non-classical monocyte	6 studies	29% ± 9%	Explore
kidney loop of Henle epithelial cell	6 studies	51% ± 24%	Explore
megakaryocyte	6 studies	67% ± 25%	Explore
mesothelial cell	6 studies	67% ± 17%	Explore
oligodendrocyte	6 studies	22% ± 8%	Explore
hematopoietic precursor cell	5 studies	58% ± 18%	Explore
mononuclear phagocyte	5 studies	35% ± 16%	Explore
renal alpha-intercalated cell	5 studies	74% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	70% ± 11%	Explore
leukocyte	5 studies	30% ± 7%	Explore
pro-B cell	5 studies	37% ± 8%	Explore
neuroendocrine cell	5 studies	82% ± 26%	Explore
immature B cell	5 studies	38% ± 10%	Explore
mucus secreting cell	5 studies	56% ± 25%	Explore
T follicular helper cell	5 studies	23% ± 6%	Explore
regulatory T cell	5 studies	20% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	24% ± 10%	Explore
deuterosomal cell	4 studies	61% ± 17%	Explore
duct epithelial cell	4 studies	86% ± 3%	Explore
pancreatic A cell	4 studies	93% ± 8%	Explore
type B pancreatic cell	4 studies	81% ± 17%	Explore
podocyte	4 studies	80% ± 12%	Explore
enteroendocrine cell	4 studies	60% ± 23%	Explore
intestinal crypt stem cell	4 studies	68% ± 15%	Explore
transit amplifying cell	4 studies	65% ± 18%	Explore
CD8-positive, alpha-beta T cell	4 studies	25% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	88% ± 9%	Explore
GABAergic neuron	4 studies	33% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	61% ± 28%	Explore
squamous epithelial cell	3 studies	59% ± 19%	Explore
pancreatic D cell	3 studies	92% ± 6%	Explore
plasmablast	3 studies	32% ± 19%	Explore
kidney connecting tubule epithelial cell	3 studies	73% ± 10%	Explore
connective tissue cell	3 studies	31% ± 11%	Explore
T cell	3 studies	45% ± 31%	Explore
renal principal cell	3 studies	82% ± 9%	Explore
extravillous trophoblast	3 studies	74% ± 15%	Explore
placental villous trophoblast	3 studies	97% ± 2%	Explore
erythroblast	3 studies	45% ± 29%	Explore
amacrine cell	3 studies	35% ± 15%	Explore
microglial cell	3 studies	29% ± 9%	Explore
alveolar macrophage	3 studies	19% ± 1%	Explore
serous secreting cell	3 studies	67% ± 0%	Explore
Mueller cell	3 studies	32% ± 4%	Explore
acinar cell	3 studies	51% ± 31%	Explore
CD4-positive, alpha-beta T cell	3 studies	23% ± 4%	Explore
granulocyte	3 studies	34% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	78% ± 3%	Explore
pancreatic ductal cell	3 studies	87% ± 7%	Explore
keratinocyte	3 studies	60% ± 5%	Explore
interneuron	3 studies	33% ± 20%	Explore
progenitor cell of mammary luminal epithelium	3 studies	58% ± 23%	Explore
neuron	3 studies	37% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	39% ± 22%	Explore
intestine	8 studies	36% ± 21%	Explore
peripheral blood	7 studies	26% ± 13%	Explore
kidney	7 studies	29% ± 11%	Explore
lymph node	5 studies	33% ± 18%	Explore
brain	5 studies	31% ± 10%	Explore
pancreas	4 studies	78% ± 18%	Explore
placenta	4 studies	59% ± 28%	Explore
prostate	4 studies	49% ± 17%	Explore
breast	4 studies	35% ± 10%	Explore
thymus	3 studies	37% ± 12%	Explore
bone marrow	3 studies	23% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	9016.59	328 / 328	98%	105.41	175 / 178
thymus	100%	22887.45	653 / 653	97%	110.50	587 / 605
lung	98%	8720.82	567 / 578	98%	99.20	1129 / 1155
ovary	93%	5420.61	168 / 180	99%	162.25	426 / 430
prostate	92%	9465.53	225 / 245	97%	81.38	489 / 502
kidney	100%	12621.33	89 / 89	87%	45.53	782 / 901
bladder	81%	6914.81	17 / 21	94%	114.78	474 / 504
stomach	76%	8710.17	272 / 359	97%	100.79	276 / 286
breast	59%	7308.25	270 / 459	97%	91.40	1087 / 1118
intestine	49%	8910.41	475 / 966	98%	113.78	515 / 527
esophagus	39%	8006.78	560 / 1445	99%	76.35	181 / 183
uterus	24%	1202.06	41 / 170	88%	103.39	404 / 459
tonsil	0%	0	0 / 0	100%	79.85	45 / 45
ureter	0%	0	0 / 0	100%	34.27	1 / 1
adrenal gland	63%	2175.72	162 / 258	28%	9.70	65 / 230
spleen	86%	3217.74	207 / 241	0%	0	0 / 0
skin	72%	11302.34	1304 / 1809	3%	0.92	14 / 472
brain	71%	3340.94	1881 / 2642	0%	0.09	3 / 705
blood vessel	67%	8921.44	893 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	41%	12.48	12 / 29
peripheral blood	39%	1272.14	361 / 929	0%	0	0 / 0
liver	2%	51.65	4 / 226	15%	10.44	61 / 406
adipose	2%	64.00	20 / 1204	0%	0	0 / 0
heart	1%	17.69	6 / 861	0%	0	0 / 0
muscle	0%	3.37	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0071711	Biological process	basement membrane organization
GO_0007163	Biological process	establishment or maintenance of cell polarity
GO_2000178	Biological process	negative regulation of neural precursor cell proliferation
GO_0071773	Biological process	cellular response to BMP stimulus
GO_2000146	Biological process	negative regulation of cell motility
GO_0001843	Biological process	neural tube closure
GO_0060672	Biological process	epithelial cell morphogenesis involved in placental branching
GO_0022408	Biological process	negative regulation of cell-cell adhesion
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0004866	Molecular function	endopeptidase inhibitor activity
GO_0004867	Molecular function	serine-type endopeptidase inhibitor activity

IV. Literature review

[source]

Gene name	SPINT2
Protein name	Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin) SPINT2 protein Serine peptidase inhibitor, Kunitz type 2
Synonyms	KOP HAI2
Description	FUNCTION: Inhibitor of HGFAC . Also inhibits plasmin, and plasma and tissue kallikrein . Inhibits serine protease activity of TMPRSS13 . Inhibits serine protease activity of ST14/matriptase in vitro . .
Accessions	K7EKC8 ENST00000590510.5 K7ES27 ENST00000587090.5 O43291 ENST00000301244.12 [O43291-1] ENST00000592007.1 K7EJS4 K7EKQ0 ENST00000587516.5 ENST00000587334.1 ENST00000590738.1 K7EM91 K7ESI5 Q6LEU8 ENST00000454580.7 [O43291-2]

SPINT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review