SNX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072673Biological processlamellipodium morphogenesis
GO_0034498Biological processearly endosome to Golgi transport
GO_0006886Biological processintracellular protein transport
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0005764Cellular componentlysosome
GO_0032991Cellular componentprotein-containing complex
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0030905Cellular componentretromer, tubulation complex
GO_0005768Cellular componentendosome
GO_0030027Cellular componentlamellipodium
GO_0042803Molecular functionprotein homodimerization activity
GO_0005158Molecular functioninsulin receptor binding
GO_1990459Molecular functiontransferrin receptor binding
GO_0045296Molecular functioncadherin binding
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_1990460Molecular functionleptin receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNX2
Protein nameSorting nexin-2 (Transformation-related gene 9 protein) (TRG-9)
Sorting nexin-2
Sorting nexin 2
SynonymsTRG9
DescriptionFUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity . Required for retrograde endosome-to-TGN transport of TGN38 . Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN . .

AccessionsENST00000379516.7 [O60749-1]
D6RC15
ENST00000512394.5
ENST00000514949.1 [O60749-2]
D6RBT1
O60749
ENST00000505934.5