SNRNP200 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	19 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	17 studies	25% ± 4%	Explore
regulatory T cell	17 studies	22% ± 4%	Explore
B cell	15 studies	21% ± 6%	Explore
T cell	14 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	14 studies	22% ± 5%	Explore
gamma-delta T cell	14 studies	24% ± 10%	Explore
endothelial cell	13 studies	25% ± 10%	Explore
memory B cell	13 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	25% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	12 studies	24% ± 6%	Explore
naive B cell	11 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	21% ± 5%	Explore
mature NK T cell	11 studies	19% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	20% ± 5%	Explore
ciliated cell	9 studies	29% ± 9%	Explore
epithelial cell	9 studies	32% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	24% ± 8%	Explore
basal cell	8 studies	25% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	21% ± 3%	Explore
mucosal invariant T cell	8 studies	23% ± 5%	Explore
fibroblast	7 studies	20% ± 3%	Explore
hematopoietic precursor cell	6 studies	22% ± 8%	Explore
abnormal cell	6 studies	26% ± 8%	Explore
retinal rod cell	6 studies	17% ± 2%	Explore
pericyte	6 studies	18% ± 2%	Explore
macrophage	6 studies	22% ± 7%	Explore
smooth muscle cell	5 studies	17% ± 1%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
classical monocyte	5 studies	24% ± 9%	Explore
precursor B cell	5 studies	27% ± 6%	Explore
innate lymphoid cell	5 studies	20% ± 4%	Explore
T follicular helper cell	5 studies	21% ± 4%	Explore
GABAergic neuron	5 studies	26% ± 8%	Explore
astrocyte	5 studies	20% ± 4%	Explore
secretory cell	4 studies	24% ± 5%	Explore
interneuron	4 studies	25% ± 14%	Explore
lymphocyte	4 studies	27% ± 7%	Explore
pro-B cell	4 studies	28% ± 6%	Explore
myofibroblast cell	4 studies	18% ± 2%	Explore
type I pneumocyte	4 studies	20% ± 5%	Explore
Mueller cell	4 studies	19% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 11%	Explore
neuron	4 studies	26% ± 7%	Explore
glutamatergic neuron	4 studies	35% ± 13%	Explore
goblet cell	4 studies	22% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	17% ± 3%	Explore
ionocyte	3 studies	28% ± 5%	Explore
respiratory goblet cell	3 studies	28% ± 5%	Explore
leukocyte	3 studies	21% ± 3%	Explore
exhausted T cell	3 studies	28% ± 8%	Explore
non-classical monocyte	3 studies	29% ± 9%	Explore
plasmablast	3 studies	36% ± 14%	Explore
retinal bipolar neuron	3 studies	19% ± 3%	Explore
microglial cell	3 studies	21% ± 3%	Explore
myeloid cell	3 studies	26% ± 4%	Explore
club cell	3 studies	22% ± 8%	Explore
immature B cell	3 studies	21% ± 3%	Explore
retinal cone cell	3 studies	25% ± 7%	Explore
CD4-positive helper T cell	3 studies	27% ± 2%	Explore
endothelial cell of vascular tree	3 studies	19% ± 1%	Explore
dendritic cell	3 studies	40% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	26% ± 0%	Explore
enteroendocrine cell	3 studies	24% ± 6%	Explore
transit amplifying cell	3 studies	31% ± 9%	Explore
double negative thymocyte	3 studies	33% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	22% ± 8%	Explore
lung	8 studies	19% ± 3%	Explore
brain	7 studies	26% ± 7%	Explore
eye	6 studies	20% ± 4%	Explore
bone marrow	3 studies	20% ± 4%	Explore
lymph node	3 studies	17% ± 1%	Explore
intestine	3 studies	23% ± 7%	Explore
liver	3 studies	30% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	12894.44	1445 / 1445	100%	117.28	183 / 183
stomach	100%	11044.17	359 / 359	100%	92.37	286 / 286
breast	100%	15916.71	459 / 459	100%	113.34	1117 / 1118
prostate	100%	14024.53	245 / 245	100%	82.34	501 / 502
lung	100%	13320.46	578 / 578	100%	95.85	1151 / 1155
intestine	100%	14739.48	966 / 966	100%	93.09	525 / 527
skin	100%	15667.84	1809 / 1809	100%	127.88	470 / 472
uterus	100%	17518.71	170 / 170	100%	89.13	457 / 459
bladder	100%	14895.29	21 / 21	99%	81.04	501 / 504
pancreas	100%	8232.13	327 / 328	99%	67.76	177 / 178
ovary	100%	19459.27	180 / 180	99%	88.93	426 / 430
thymus	100%	14894.20	653 / 653	99%	75.96	599 / 605
brain	99%	8763.44	2605 / 2642	100%	127.20	705 / 705
kidney	100%	9424.08	89 / 89	98%	73.10	884 / 901
adrenal gland	100%	12944.94	258 / 258	95%	51.45	219 / 230
liver	100%	6148.61	225 / 226	93%	46.57	378 / 406
adipose	100%	13794.01	1204 / 1204	0%	0	0 / 0
blood vessel	100%	13311.17	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	93.34	80 / 80
lymph node	0%	0	0 / 0	100%	81.01	29 / 29
muscle	100%	11508.68	803 / 803	0%	0	0 / 0
spleen	100%	17244.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	98.93	45 / 45
ureter	0%	0	0 / 0	100%	24.57	1 / 1
heart	98%	7379.84	841 / 861	0%	0	0 / 0
peripheral blood	95%	11353.89	886 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000388	Biological process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO_0001649	Biological process	osteoblast differentiation
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0000354	Biological process	cis assembly of pre-catalytic spliceosome
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0005681	Cellular component	spliceosomal complex
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0071006	Cellular component	U2-type catalytic step 1 spliceosome
GO_0005682	Cellular component	U5 snRNP
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005634	Cellular component	nucleus
GO_0004386	Molecular function	helicase activity
GO_0003724	Molecular function	RNA helicase activity
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	SNRNP200
Protein name	U5 small nuclear ribonucleoprotein 200 kDa helicase SNRNP200 protein U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)
Synonyms	KIAA0788 HELIC2 ASCC3L1 BRR2
Description	FUNCTION: Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome . Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes . As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. .
Accessions	A4FU77 Q7L5W4 A0A494C1A5 A2RRQ7 ENST00000323853.10 [O75643-1] ENST00000652267.1 O75643

SNRNP200 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review