SMYD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0045184Biological processestablishment of protein localization
GO_0014904Biological processmyotube cell development
GO_0032259Biological processmethylation
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006334Biological processnucleosome assembly
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0140999Molecular functionhistone H3K4 trimethyltransferase activity
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0140954Molecular functionhistone H3K36 dimethyltransferase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001162Molecular functionRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO_0140939Molecular functionhistone H4 methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSMYD3
Protein name[histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354)
SET and MYND domain containing 3, isoform CRA_a (cDNA FLJ13532 fis, clone PLACE1006318, highly similar to SET and MYND domain-containing protein 3)
Alternative protein SMYD3
Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.354) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1)
SET and MYND domain containing 3
SynonymsZMYND1
ZNFN3A1
hCG_1810860
DescriptionFUNCTION: Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation . Also methylates 'Lys-5' of histone H4 . Plays an important role in transcriptional activation as a member of an RNA polymerase complex . Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences . .

AccessionsQ9H7B4
B3KN46
ENST00000630181.2 [Q9H7B4-3]
Q3B7A0
B0QZA0
B0QZ88
ENST00000391836.3
ENST00000403792.7
L0R6Q4
ENST00000455277.2
B0QZ99
A8MXR1
ENST00000490107.6 [Q9H7B4-1]
ENST00000453676.5