Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 25 studies | 48% ± 19% | |
mast cell | 24 studies | 48% ± 23% | |
astrocyte | 19 studies | 53% ± 19% | |
microglial cell | 16 studies | 50% ± 17% | |
oligodendrocyte precursor cell | 14 studies | 52% ± 14% | |
fibroblast | 14 studies | 43% ± 15% | |
macrophage | 13 studies | 39% ± 16% | |
smooth muscle cell | 12 studies | 36% ± 15% | |
glutamatergic neuron | 12 studies | 79% ± 17% | |
oligodendrocyte | 12 studies | 32% ± 16% | |
pericyte | 12 studies | 39% ± 14% | |
GABAergic neuron | 11 studies | 68% ± 21% | |
adipocyte | 9 studies | 43% ± 13% | |
ciliated cell | 9 studies | 38% ± 22% | |
neuron | 8 studies | 50% ± 25% | |
epithelial cell | 8 studies | 44% ± 17% | |
endothelial cell of lymphatic vessel | 8 studies | 44% ± 16% | |
B cell | 7 studies | 38% ± 11% | |
interneuron | 6 studies | 73% ± 17% | |
mesothelial cell | 6 studies | 41% ± 15% | |
T cell | 6 studies | 47% ± 16% | |
myeloid cell | 6 studies | 40% ± 11% | |
monocyte | 6 studies | 35% ± 14% | |
club cell | 6 studies | 51% ± 25% | |
basal cell | 6 studies | 51% ± 23% | |
retinal ganglion cell | 5 studies | 74% ± 25% | |
cardiac muscle cell | 5 studies | 43% ± 9% | |
natural killer cell | 5 studies | 45% ± 15% | |
type I pneumocyte | 5 studies | 76% ± 4% | |
type II pneumocyte | 5 studies | 77% ± 10% | |
granule cell | 4 studies | 77% ± 10% | |
plasma cell | 4 studies | 46% ± 17% | |
CD4-positive, alpha-beta T cell | 4 studies | 36% ± 11% | |
CD8-positive, alpha-beta T cell | 4 studies | 35% ± 11% | |
dendritic cell | 4 studies | 32% ± 5% | |
Mueller cell | 4 studies | 36% ± 16% | |
amacrine cell | 4 studies | 49% ± 12% | |
retina horizontal cell | 4 studies | 47% ± 17% | |
retinal cone cell | 4 studies | 87% ± 13% | |
retinal rod cell | 4 studies | 55% ± 11% | |
leukocyte | 4 studies | 58% ± 3% | |
cholangiocyte | 3 studies | 41% ± 16% | |
hepatic stellate cell | 3 studies | 45% ± 20% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 39% ± 18% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 52% ± 11% | |
GABAergic interneuron | 3 studies | 78% ± 6% | |
glial cell | 3 studies | 38% ± 19% | |
progenitor cell | 3 studies | 45% ± 13% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 30% ± 18% | |
vein endothelial cell | 3 studies | 43% ± 18% | |
GABAergic amacrine cell | 3 studies | 44% ± 9% | |
OFF-bipolar cell | 3 studies | 57% ± 16% | |
ON-bipolar cell | 3 studies | 62% ± 12% | |
glycinergic amacrine cell | 3 studies | 50% ± 5% | |
endothelial cell of vascular tree | 3 studies | 45% ± 8% | |
hepatocyte | 3 studies | 55% ± 13% | |
retinal pigment epithelial cell | 3 studies | 50% ± 17% | |
ependymal cell | 3 studies | 59% ± 14% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 44% ± 21% | |
alveolar macrophage | 3 studies | 47% ± 6% | |
capillary endothelial cell | 3 studies | 37% ± 3% | |
myofibroblast cell | 3 studies | 39% ± 14% | |
respiratory goblet cell | 3 studies | 63% ± 21% | |
abnormal cell | 3 studies | 43% ± 25% | |
lymphocyte | 3 studies | 52% ± 8% | |
muscle cell | 3 studies | 42% ± 28% | |
mucus secreting cell | 3 studies | 54% ± 1% | |
regulatory T cell | 3 studies | 42% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 889.68 | 2633 / 2642 | 100% | 14.71 | 704 / 705 |
thymus | 100% | 1222.50 | 652 / 653 | 100% | 15.86 | 603 / 605 |
breast | 100% | 616.80 | 459 / 459 | 99% | 23.42 | 1112 / 1118 |
ovary | 100% | 505.10 | 180 / 180 | 99% | 10.01 | 426 / 430 |
prostate | 100% | 465.58 | 244 / 245 | 99% | 12.53 | 498 / 502 |
skin | 100% | 761.56 | 1807 / 1809 | 99% | 15.03 | 466 / 472 |
lung | 100% | 782.11 | 577 / 578 | 99% | 14.66 | 1140 / 1155 |
intestine | 100% | 487.11 | 966 / 966 | 97% | 10.40 | 512 / 527 |
bladder | 100% | 673.24 | 21 / 21 | 97% | 14.65 | 488 / 504 |
stomach | 100% | 403.64 | 359 / 359 | 97% | 8.93 | 276 / 286 |
adrenal gland | 100% | 917.14 | 258 / 258 | 92% | 9.37 | 212 / 230 |
pancreas | 91% | 206.34 | 297 / 328 | 99% | 11.83 | 176 / 178 |
uterus | 100% | 512.31 | 170 / 170 | 89% | 11.88 | 410 / 459 |
esophagus | 99% | 474.07 | 1428 / 1445 | 90% | 7.12 | 164 / 183 |
kidney | 99% | 502.09 | 88 / 89 | 89% | 7.17 | 806 / 901 |
liver | 77% | 155.98 | 175 / 226 | 87% | 8.96 | 353 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.34 | 29 / 29 |
spleen | 100% | 424.42 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.66 | 1 / 1 |
adipose | 100% | 508.72 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 441.65 | 1325 / 1335 | 0% | 0 | 0 / 0 |
muscle | 97% | 345.66 | 781 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 9.70 | 77 / 80 |
heart | 92% | 299.95 | 792 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 8.20 | 41 / 45 |
peripheral blood | 72% | 352.56 | 673 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
GO_0045184 | Biological process | establishment of protein localization |
GO_0014904 | Biological process | myotube cell development |
GO_0032259 | Biological process | methylation |
GO_0071549 | Biological process | cellular response to dexamethasone stimulus |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0006334 | Biological process | nucleosome assembly |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0140999 | Molecular function | histone H3K4 trimethyltransferase activity |
GO_0000993 | Molecular function | RNA polymerase II complex binding |
GO_0140954 | Molecular function | histone H3K36 dimethyltransferase activity |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0001162 | Molecular function | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding |
GO_0140939 | Molecular function | histone H4 methyltransferase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | SMYD3 |
Protein name | [histone H3]-lysine(4) N-trimethyltransferase (EC 2.1.1.354) SET and MYND domain containing 3, isoform CRA_a (cDNA FLJ13532 fis, clone PLACE1006318, highly similar to SET and MYND domain-containing protein 3) Alternative protein SMYD3 Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.354) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1) SET and MYND domain containing 3 |
Synonyms | ZMYND1 ZNFN3A1 hCG_1810860 |
Description | FUNCTION: Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation . Also methylates 'Lys-5' of histone H4 . Plays an important role in transcriptional activation as a member of an RNA polymerase complex . Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences . . |
Accessions | Q9H7B4 B3KN46 ENST00000630181.2 [Q9H7B4-3] Q3B7A0 B0QZA0 B0QZ88 ENST00000391836.3 ENST00000403792.7 L0R6Q4 ENST00000455277.2 B0QZ99 A8MXR1 ENST00000490107.6 [Q9H7B4-1] ENST00000453676.5 |