SF3B4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_1903241Biological processU2-type prespliceosome assembly
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0006397Biological processmRNA processing
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0005686Cellular componentU2 snRNP
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0071005Cellular componentU2-type precatalytic spliceosome
GO_0005689Cellular componentU12-type spliceosomal complex
GO_0005684Cellular componentU2-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_1990935Molecular functionsplicing factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSF3B4
Protein nameSplicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49)
Splicing factor 3b subunit 4 (Splicing factor 3b, subunit 4, 49kDa)
SynonymsSAP49
RP11-196G18.20-002
DescriptionFUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA . Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA . May also be involved in the assembly of the 'E' complex . Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs . .

AccessionsENST00000271628.9
Q5SZ64
ENST00000457312.1
Q15427