SAFB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	17 studies	20% ± 4%	Explore
endothelial cell	16 studies	26% ± 10%	Explore
natural killer cell	13 studies	21% ± 4%	Explore
naive B cell	13 studies	20% ± 4%	Explore
memory B cell	12 studies	18% ± 3%	Explore
ciliated cell	11 studies	27% ± 9%	Explore
regulatory T cell	11 studies	20% ± 3%	Explore
fibroblast	11 studies	20% ± 5%	Explore
CD8-positive, alpha-beta T cell	10 studies	20% ± 3%	Explore
T cell	9 studies	18% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	18% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	19% ± 3%	Explore
macrophage	9 studies	26% ± 9%	Explore
gamma-delta T cell	9 studies	23% ± 11%	Explore
microglial cell	8 studies	27% ± 9%	Explore
mucosal invariant T cell	8 studies	18% ± 3%	Explore
epithelial cell	8 studies	34% ± 17%	Explore
plasmacytoid dendritic cell	8 studies	22% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	18% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	20% ± 3%	Explore
CD4-positive, alpha-beta T cell	7 studies	20% ± 4%	Explore
pericyte	7 studies	22% ± 7%	Explore
smooth muscle cell	7 studies	17% ± 1%	Explore
oligodendrocyte	7 studies	25% ± 9%	Explore
mast cell	6 studies	18% ± 2%	Explore
classical monocyte	6 studies	22% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
interneuron	6 studies	27% ± 19%	Explore
oligodendrocyte precursor cell	6 studies	25% ± 11%	Explore
basal cell	6 studies	28% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	21% ± 3%	Explore
astrocyte	6 studies	27% ± 9%	Explore
mature NK T cell	5 studies	17% ± 1%	Explore
glutamatergic neuron	5 studies	40% ± 19%	Explore
myofibroblast cell	5 studies	20% ± 3%	Explore
myeloid cell	5 studies	22% ± 4%	Explore
GABAergic neuron	5 studies	34% ± 15%	Explore
dendritic cell	5 studies	29% ± 14%	Explore
goblet cell	5 studies	29% ± 14%	Explore
hematopoietic precursor cell	4 studies	22% ± 6%	Explore
non-classical monocyte	4 studies	23% ± 6%	Explore
neuron	4 studies	32% ± 12%	Explore
immature B cell	4 studies	22% ± 5%	Explore
adipocyte	4 studies	19% ± 3%	Explore
lymphocyte	4 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	4 studies	23% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
innate lymphoid cell	4 studies	17% ± 2%	Explore
abnormal cell	4 studies	25% ± 6%	Explore
monocyte	4 studies	20% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	19% ± 5%	Explore
conventional dendritic cell	3 studies	36% ± 16%	Explore
plasmablast	3 studies	32% ± 12%	Explore
connective tissue cell	3 studies	20% ± 3%	Explore
neural crest cell	3 studies	17% ± 1%	Explore
progenitor cell	3 studies	20% ± 1%	Explore
precursor B cell	3 studies	23% ± 4%	Explore
pro-B cell	3 studies	26% ± 1%	Explore
type I pneumocyte	3 studies	21% ± 3%	Explore
type II pneumocyte	3 studies	20% ± 2%	Explore
T follicular helper cell	3 studies	18% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore
leukocyte	3 studies	21% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 10%	Explore
transit amplifying cell	3 studies	32% ± 12%	Explore
double negative thymocyte	3 studies	29% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	19% ± 5%	Explore
brain	8 studies	31% ± 14%	Explore
lung	6 studies	22% ± 5%	Explore
intestine	4 studies	21% ± 6%	Explore
adipose	3 studies	18% ± 2%	Explore
liver	3 studies	30% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	6171.57	21 / 21	100%	53.29	504 / 504
intestine	100%	6761.01	966 / 966	100%	49.30	527 / 527
pancreas	100%	3360.77	328 / 328	100%	46.48	178 / 178
skin	100%	7362.47	1809 / 1809	100%	68.31	472 / 472
thymus	100%	6511.09	653 / 653	100%	55.30	605 / 605
uterus	100%	7660.99	170 / 170	100%	62.41	459 / 459
prostate	100%	7092.38	245 / 245	100%	51.52	501 / 502
liver	100%	3233.23	226 / 226	100%	30.90	405 / 406
stomach	100%	4782.70	359 / 359	100%	41.19	285 / 286
adrenal gland	100%	5338.67	258 / 258	100%	44.28	229 / 230
breast	100%	6505.09	459 / 459	99%	51.06	1112 / 1118
esophagus	100%	5867.50	1445 / 1445	99%	36.93	182 / 183
kidney	100%	4917.61	89 / 89	99%	35.67	896 / 901
brain	100%	5513.69	2639 / 2642	99%	60.15	701 / 705
lung	100%	6596.48	578 / 578	99%	44.28	1146 / 1155
ovary	100%	7257.42	180 / 180	99%	27.53	426 / 430
adipose	100%	6048.27	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	70.56	80 / 80
lymph node	0%	0	0 / 0	100%	83.18	29 / 29
muscle	100%	6508.90	803 / 803	0%	0	0 / 0
spleen	100%	8226.25	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	61.92	45 / 45
ureter	0%	0	0 / 0	100%	42.63	1 / 1
blood vessel	100%	5757.06	1334 / 1335	0%	0	0 / 0
peripheral blood	99%	5674.28	919 / 929	0%	0	0 / 0
heart	99%	4000.01	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0050684	Biological process	regulation of mRNA processing
GO_0030520	Biological process	estrogen receptor signaling pathway
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0030496	Cellular component	midbody
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0003690	Molecular function	double-stranded DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515	Molecular function	protein binding
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding

IV. Literature review

[source]

Gene name	SAFB
Protein name	Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein) SAFB protein Scaffold attachment factor B
Synonyms	HAP HET SAFB1
Description	FUNCTION: Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing . Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription . Thereby acts as a negative regulator of cell proliferation . When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). .
Accessions	Q15424 ENST00000589863.5 K7ES42 B7ZLP5 ENST00000592224.5 [Q15424-4] K7EII0 ENST00000589006.1 ENST00000588852.2 [Q15424-3] ENST00000292123.9 [Q15424-1] ENST00000454510.5 [Q15424-2]

SAFB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review