RNMT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	30 studies	27% ± 12%	Explore
natural killer cell	25 studies	25% ± 10%	Explore
fibroblast	25 studies	24% ± 11%	Explore
macrophage	19 studies	24% ± 10%	Explore
endothelial cell	19 studies	26% ± 12%	Explore
CD4-positive, alpha-beta T cell	19 studies	25% ± 13%	Explore
T cell	18 studies	22% ± 8%	Explore
CD8-positive, alpha-beta T cell	18 studies	24% ± 10%	Explore
naive B cell	17 studies	30% ± 10%	Explore
memory B cell	17 studies	26% ± 8%	Explore
regulatory T cell	17 studies	26% ± 10%	Explore
monocyte	14 studies	19% ± 3%	Explore
classical monocyte	14 studies	24% ± 9%	Explore
pericyte	14 studies	21% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	27% ± 10%	Explore
gamma-delta T cell	13 studies	29% ± 11%	Explore
plasmacytoid dendritic cell	12 studies	29% ± 10%	Explore
mature NK T cell	11 studies	24% ± 6%	Explore
mucosal invariant T cell	11 studies	24% ± 7%	Explore
astrocyte	11 studies	27% ± 7%	Explore
mast cell	10 studies	22% ± 7%	Explore
smooth muscle cell	10 studies	19% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	31% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	30% ± 13%	Explore
microglial cell	10 studies	26% ± 10%	Explore
non-classical monocyte	9 studies	29% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	31% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	29% ± 15%	Explore
GABAergic neuron	9 studies	37% ± 19%	Explore
epithelial cell	9 studies	36% ± 20%	Explore
oligodendrocyte	9 studies	28% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	31% ± 13%	Explore
glutamatergic neuron	8 studies	45% ± 22%	Explore
myeloid cell	8 studies	24% ± 10%	Explore
adipocyte	8 studies	27% ± 8%	Explore
endothelial cell of lymphatic vessel	7 studies	21% ± 3%	Explore
connective tissue cell	7 studies	20% ± 3%	Explore
retinal rod cell	7 studies	26% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	33% ± 10%	Explore
oligodendrocyte precursor cell	7 studies	27% ± 7%	Explore
abnormal cell	6 studies	27% ± 8%	Explore
neuron	6 studies	33% ± 9%	Explore
basal cell	6 studies	34% ± 13%	Explore
ciliated cell	6 studies	35% ± 14%	Explore
amacrine cell	6 studies	38% ± 15%	Explore
retinal cone cell	6 studies	37% ± 13%	Explore
leukocyte	5 studies	31% ± 9%	Explore
conventional dendritic cell	5 studies	34% ± 16%	Explore
myofibroblast cell	5 studies	25% ± 7%	Explore
progenitor cell	5 studies	17% ± 1%	Explore
retinal ganglion cell	5 studies	49% ± 24%	Explore
retina horizontal cell	5 studies	34% ± 9%	Explore
cardiac muscle cell	5 studies	23% ± 6%	Explore
dendritic cell	5 studies	33% ± 21%	Explore
Mueller cell	5 studies	30% ± 7%	Explore
T follicular helper cell	5 studies	27% ± 7%	Explore
goblet cell	5 studies	29% ± 20%	Explore
interneuron	5 studies	44% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 9%	Explore
mononuclear phagocyte	4 studies	23% ± 6%	Explore
plasmablast	4 studies	36% ± 15%	Explore
retinal bipolar neuron	4 studies	36% ± 11%	Explore
precursor B cell	4 studies	22% ± 4%	Explore
club cell	4 studies	25% ± 7%	Explore
immature B cell	4 studies	29% ± 7%	Explore
retinal pigment epithelial cell	4 studies	35% ± 17%	Explore
mesothelial cell	4 studies	24% ± 4%	Explore
lymphocyte	4 studies	28% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	35% ± 16%	Explore
innate lymphoid cell	4 studies	24% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	28% ± 16%	Explore
capillary endothelial cell	3 studies	16% ± 1%	Explore
neural crest cell	3 studies	22% ± 3%	Explore
glial cell	3 studies	22% ± 8%	Explore
OFF-bipolar cell	3 studies	32% ± 8%	Explore
ON-bipolar cell	3 studies	29% ± 8%	Explore
rod bipolar cell	3 studies	33% ± 5%	Explore
intermediate monocyte	3 studies	38% ± 21%	Explore
CD4-positive helper T cell	3 studies	28% ± 8%	Explore
myoepithelial cell	3 studies	26% ± 7%	Explore
muscle cell	3 studies	33% ± 18%	Explore
type I pneumocyte	3 studies	23% ± 3%	Explore
alveolar macrophage	3 studies	24% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	26% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	22% ± 5%	Explore
double negative thymocyte	3 studies	37% ± 12%	Explore
double-positive, alpha-beta thymocyte	3 studies	40% ± 15%	Explore
erythrocyte	3 studies	27% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	30% ± 16%	Explore
peripheral blood	13 studies	31% ± 12%	Explore
lung	9 studies	27% ± 10%	Explore
eye	9 studies	31% ± 11%	Explore
heart	4 studies	19% ± 3%	Explore
intestine	4 studies	24% ± 7%	Explore
liver	4 studies	26% ± 9%	Explore
kidney	3 studies	16% ± 1%	Explore
placenta	3 studies	27% ± 6%	Explore
uterus	3 studies	27% ± 14%	Explore
lymph node	3 studies	22% ± 4%	Explore
adipose	3 studies	24% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2776.81	1445 / 1445	100%	28.10	183 / 183
ovary	100%	3854.24	180 / 180	100%	23.54	430 / 430
lung	100%	2508.62	578 / 578	100%	24.09	1154 / 1155
brain	100%	2911.91	2635 / 2642	100%	29.30	705 / 705
breast	100%	2920.24	459 / 459	100%	27.88	1115 / 1118
stomach	100%	2162.57	359 / 359	100%	18.67	285 / 286
prostate	100%	2961.74	245 / 245	100%	19.70	500 / 502
thymus	100%	3452.25	653 / 653	100%	28.13	602 / 605
intestine	100%	2764.65	966 / 966	99%	18.30	523 / 527
bladder	100%	2967.48	21 / 21	99%	19.74	500 / 504
pancreas	100%	1714.54	328 / 328	99%	19.39	176 / 178
uterus	100%	3225.76	170 / 170	98%	21.94	450 / 459
kidney	100%	2100.87	89 / 89	98%	19.19	881 / 901
skin	100%	3453.62	1809 / 1809	97%	35.05	459 / 472
adrenal gland	100%	2316.85	258 / 258	94%	19.62	217 / 230
liver	100%	1465.21	226 / 226	90%	10.41	366 / 406
adipose	100%	2839.25	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2785.52	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.52	29 / 29
muscle	100%	2638.65	803 / 803	0%	0	0 / 0
spleen	100%	2682.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	22.42	45 / 45
ureter	0%	0	0 / 0	100%	7.57	1 / 1
heart	97%	2519.41	838 / 861	0%	0	0 / 0
peripheral blood	92%	2610.40	858 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	91%	13.07	73 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0106005	Biological process	RNA 5'-cap (guanine-N7)-methylation
GO_0006370	Biological process	7-methylguanosine mRNA capping
GO_0031533	Cellular component	mRNA capping enzyme complex
GO_0005654	Cellular component	nucleoplasm
GO_0043235	Cellular component	receptor complex
GO_0160130	Cellular component	mRNA cap methyltransferase RNMT:RAMAC complex
GO_0001650	Cellular component	fibrillar center
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0004482	Molecular function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RNMT
Protein name	mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7))-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) mRNA (guanine-N(7))-methyltransferase (EC 2.1.1.56) (RG7MT1) RNA guanine-7 methyltransferase
Synonyms	KIAA0398
Description	FUNCTION: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs . Binds RNA containing 5'-terminal GpppC . .
Accessions	Q05DQ2 ENST00000262173.7 [O43148-1] ENST00000593007.1 ENST00000589866.5 [O43148-1] O43148 Q05D80 ENST00000543302.6 [O43148-1] ENST00000592764.5 [O43148-2] K7EPP5 ENST00000383314.7 [O43148-1] ENST00000591746.1 ENST00000588457.5 K7EP06 K7ERH6

RNMT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review