7-methylguanosine mRNA capping

I. Literature review

[source]
Name7-methylguanosine mRNA capping
IDGO_0006370
collection_id

Biological process

Exact synonym

5' mRNA capping, 5'-end mRNA processing, mRNA capping

Description

The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adjacent to the m7G nRNA cap. These methylations are often referred to as N6,2'-O-dimethyladenosine (m6,2A) and N6,2'-O-dimethylguanosine (m6,2G), respectively.

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Genes