NCBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006408Biological processsnRNA export from nucleus
GO_0031053Biological processprimary miRNA processing
GO_0030307Biological processpositive regulation of cell growth
GO_0031124Biological processmRNA 3'-end processing
GO_0050684Biological processregulation of mRNA processing
GO_0031442Biological processpositive regulation of mRNA 3'-end processing
GO_0051607Biological processdefense response to virus
GO_0008334Biological processhistone mRNA metabolic process
GO_0006370Biological process7-methylguanosine mRNA capping
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0006401Biological processRNA catabolic process
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006406Biological processmRNA export from nucleus
GO_0035195Biological processmiRNA-mediated post-transcriptional gene silencing
GO_0016071Biological processmRNA metabolic process
GO_1905216Biological processpositive regulation of RNA binding
GO_0008380Biological processRNA splicing
GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0006446Biological processregulation of translational initiation
GO_0002191Biological processcap-dependent translational initiation
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0000245Biological processspliceosomal complex assembly
GO_0005739Cellular componentmitochondrion
GO_0005846Cellular componentnuclear cap binding complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0034518Cellular componentRNA cap binding complex
GO_0005634Cellular componentnucleus
GO_0000339Molecular functionRNA cap binding
GO_0000340Molecular functionRNA 7-methylguanosine cap binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCBP1
Protein nameNuclear cap binding protein subunit 1
Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)
SynonymsNCBP
CBP80
DescriptionFUNCTION: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability . .

AccessionsQ09161
ENST00000478100.3
ENST00000629069.1
ENST00000375147.8
F2Z2T1
X6R941
ENST00000375130.2